A Review on Heterogeneous Catalysts Containing Basic Active Sites for Biodiesel Production
DOI:
https://doi.org/10.33003/fjs-2026-1020-6178Keywords:
Heterogenous Catalyst, Basic Active Sites, Transesterification, Solid Base Catalyst, Biodiesel ProductionAbstract
The production of biodiesel using transesterification has drawn significant scientific interest as a renewable and eco-friendly substitute for petroleum diesel. Among the catalytic systems studied, heterogeneous catalysts with basic active sites have emerged as leading candidates due to their high catalytic activity, ease of separation, and reusability. This review synthesizes findings from 54 studies published between 2015 and 2026, examining the role of basic active sites in the transesterification mechanism across alkaline earth metal oxides, mixed metal oxides, supported catalysts, waste-derived catalysts, hydrotalcites, zeolites, metal-organic frameworks, and nanostructured materials. Catalytic performance is governed largely by surface area, pore structure, and the density, strength, and accessibility of basic active sites. CaO-based catalysts remain the most widely studied, reporting biodiesel yields above 90% under optimized conditions owing to strong basicity and low cost, though they remain susceptible to deactivation via carbonation and hydration.Waste-derived catalysts offer sustainable, low-cost alternatives, while mixed-metal and doped systems show improved stability, retaining activity over multiple reaction cycles depending on catalyst type.Despite these advances, large-scale application remains constrained by feedstock quality, active-species leaching, and catalyst deactivation. Future research should prioritize highly stable, reusable, and cost-effective catalysts with improved basic-site accessibility, alongside standardized reporting of reaction conditions to enable meaningful comparison across studies.
References
Ali, A. M., Shuaibu, H., & Ibrahim, H. (2026). Statistical evaluation and optimisation of biodiesel production from Gmelina arborea leaf biomass using calcium hydroxide catalysis under mild conditions. Fudma Journal of Sciences, 10(3), 94–101. https://doi.org/10.33003/fjs-2026-1003-4746
Abo, L. D., & Areti, H. A. (2025). Advancements in heterogeneous biobased and bio-composite catalysts: A comprehensive review on synthesis, characterizations, and applications in biodiesel production. BioEnergy Research, 18(1), 68.
Ahmed, S. N., & Haider, W. (2018). Heterogeneous photocatalysis and its potential applications in water and wastewater treatment: A review. Nanotechnology, 29(34), 342001.
Argyle, M. D., & Bartholomew, C. H. (2015). Heterogeneous catalyst deactivation and regeneration: A review. Catalysts, 5(1), 145–269.
Bano, S., Ganie, A. S., Sultana, S., Sabir, S., & Khan, M. Z. (2020). Fabrication and optimization of nanocatalyst for biodiesel production: An overview. Frontiers in Energy Research, 8, 579014.
Bhan, S., Kumar, S., Gautam, R., Yadav, P. S., Gautam, G. D., & Mahajan, S. (2025). Innovative catalytic approaches for optimizing biodiesel production: A review of homogeneous, heterogeneous, enzymatic, and nanostructured catalysts. Environmental Progress & Sustainable Energy, 44(5), e70052.
Bing, W., & Wei, M. (2019). Recent advances for solid basic catalysts: Structure design and catalytic performance. Journal of Solid State Chemistry, 269, 184–194.
Bingwa, N., Bewana, S., Ndolomingo, M. J., Mawila, N., Mogudi, B., Ncube, P., & Meijboom, R. (2018). Effect of alkali and alkaline earth metal dopants on catalytic activity of mesoporous cobalt oxide evaluated using a model reaction. Applied Catalysis A: General, 555, 189–195.
Bulavchenko, O. A., & Vinokurov, Z. S. (2023). In situ X-ray diffraction as a basic tool to study oxide and metal oxide catalysts. Catalysts, 13(11), 1421.
Burmana, A. D., & Manurung, R. (2026). Investigate biodiesel products using heterogeneous catalysts in variations lauric acid feedstock through elemental analysis and emissions testing using diesel engines. Catalysis Today, 115686.
Dias, A. P. S., & Ramos, M. (2021). On the storage stability of CaO biodiesel catalyst: Hydration and carbonation poisoning. Journal of Environmental Chemical Engineering, 9(1), 104917.
Etim, A. O. (2022). Experimental and computational exploration of advanced biodiesel fuels and hybridisation process evaluation of feedstocks and their chemical combinations (Doctoral dissertation).
Fan, Z., Gao, F., Zhang, J., Yi, L., Luo, N., Yi, H., & Tang, X. (2025). Advances in CO catalytic oxidation on typical metal oxide catalysts: Performance, mechanism, and optimization. Journal of Materials Chemistry A, 13(32), 26129–26165.
Feng, J., He, Y., Liu, Y., Du, Y., & Li, D. (2015). Supported catalysts based on layered double hydroxides for catalytic oxidation and hydrogenation: General functionality and promising application prospects. Chemical Society Reviews, 44(15), 5291–5319.
Fu, H., Yu, Y., Diaz, J., Yao, Y., Chi, M., & Huang, Z. (2026). Recent advances in alkali and alkaline-earth metal doping for layered sodium-ion oxide cathodes. EES Batteries.
Gao, X., Cai, P., Wang, Z., Lv, X., & Kawi, S. (2023). Surface acidity/basicity and oxygen defects of metal oxide: Impacts on catalytic performances of CO₂ reforming and hydrogenation reactions. Topics in Catalysis, 66(5), 299–325.
Hamood ur Rehman, M., Hussain, M., Akhter, P., & Jamil, F. (2025). Breaking barriers in biodiesel: From feedstock challenges to technological advancements. Chemistry Africa, 8(6), 2225–2256.
Jambhulkar, D. K., Ugwekar, R. P., Bhanvase, B. A., & Barai, D. P. (2022). A review on solid base heterogeneous catalysts: Preparation, characterization and applications. Chemical Engineering Communications, 209(4), 433–484.
Jawad, S. E. Z., Fatima, B., & Najam-ul-Haq, M. (2023). Metal phosphates/phosphonates for biofuels. In Metal phosphates and phosphonates: Fundamental to advanced emerging applications (pp. 209–225). Springer International Publishing.
Julkapli, N. M., & Bagheri, S. (2016). Magnesium oxide as a heterogeneous catalyst support. Reviews in Inorganic Chemistry, 36(1), 1.
Katajisto, O. (2020). Calcination of calcium carbonate based materials in electric heated rotary kiln [Master’s thesis, Tampere University].
Khan, H., Yerramilli, A. S., D'Oliveira, A., Alford, T. L., Boffito, D. C., & Patience, G. S. (2020). Experimental methods in chemical engineering: X-ray diffraction spectroscopy—XRD. The Canadian Journal of Chemical Engineering, 98(6), 1255–1266.
Lakhani, P., & Srifa, A. (2026). Emerging heterogeneous catalysis for valorization of biomass-derived platform molecules: The systematic review toward sustainable biorefinery applications. Advanced Energy and Sustainability Research, 7(2), e202500402.
Lawal, M. M., Govender, T., Maguire, G. E., Kruger, H. G., & Honarparvar, B. (2018). DFT study of the acid-catalyzed esterification reaction mechanism of methanol with carboxylic acid 1and its halide derivatives. International Journal of Quantum Chemistry, 118(4), e25497.
Loh, C. Y., Mohamed, A. R., & Lai, S. Y. (2025). Biodiesel production from palm oil using barium oxide-reduced graphene oxide. Fuel, 386, 134210.
Loy, A. C. M., Ng, W. L., & Bhattacharya, S. (2024). Advanced characterization techniques for the development of subatomic scale catalysts: One step closer to industrial scale fabrication. Materials Today Catalysis, 4, 100033.
Mansir, N., Taufiq-Yap, Y. H., Rashid, U., & Lokman, I. M. (2017). Investigation of heterogeneous solid acid catalyst performance on low grade feedstocks for biodiesel production: A review. Energy Conversion and Management, 141, 171–182.
Mazaheri, H., Ong, H. C., Amini, Z., Masjuki, H. H., Mofijur, M., Su, C. H., & Khan, T. Y. (2021). An overview of biodiesel production via calcium oxide based catalysts: Current state and perspective. Energies, 14(13), 3950.
Melnikov, F., Geohagen, B. C., Gavin, T., LoPachin, R. M., Anastas, P. T., Coish, P., & Herr, D. W. (2020). Application of the hard and soft, acids and bases (HSAB) theory as a method to predict cumulative neurotoxicity. Neurotoxicology, 79, 95–103.
Miceli, M., Frontera, P., Macario, A., & Malara, A. (2021). Recovery/reuse of heterogeneous supported spent catalysts. Catalysts, 11(5), 591.
Mirshafiee,F., & Rezaei, M. (2025). Optimizing Al/Zn ratios in K2O/Zn-aluminate catalysts for enhanced biodiesel production efficiency.Scientic Report, 15(1), 25293.
Navajas, A., Campo, I., Moral, A., Echave, J., Sanz, O., Montes, M., & Gandía, L. M. (2018). Outstanding performance of rehydrated Mg-Al hydrotalcites as heterogeneous methanolysis catalysts for the synthesis of biodiesel. Fuel, 211, 173–181.
Neupane, D. (2022). Biofuels from renewable sources, a potential option for biodiesel production. Bioengineering, 10(1), 29.
Ogunkunle, O., & Ahmed, N. A. (2021). Overview of biodiesel combustion in mitigating the adverse impacts of engine emissions on the sustainable human–environment scenario. Sustainability, 13(10), 5465.
Papargyriou, D., Broumidis, E., de Vere-Tucker, M., Gavrielides, S., Hilditch, P., Irvine, J. T., & Bonaccorso, A. D. (2019). Investigation of solid base catalysts for biodiesel production from fish oil. Renewable Energy, 139, 661–669.
Parangi, T. (2025). Heterogeneous catalysis: An alternative approach for energy and environment. Reviews in Inorganic Chemistry, 45(4), 831–861.
Pedro, A. Q., Coutinho, J. A., & Freire, M. G. (2019). Immobilization of ionic liquids, types of materials, and applications. Encyclopedia of Ionic Liquids, 1–12.
Ruhul, A. M., Kalam, M. A., Masjuki, H. H., Fattah, I. R., Reham, S. S., & Rashed, M. M. (2015). State of the art of biodiesel production processes: A review of the heterogeneous catalyst. RSC Advances, 5(122), 101023–101044.
Sadeghpour, A., Javid, M., Koduru, S., Babaei, S., & Brevik, E. C. (2025). Heavy metals in bioenergy crop production, biomass quality, and biorefinery: Global impacts and sustainable management strategies. Bioresources and Bioproducts, 1(1), 2.
Sambalova, O., Billeter, E., Mann, J., Miyayama, T., Burnat, D., Heel, A., & Borgschulte, A. (2020). Hard and soft X-ray photoelectron spectroscopy for selective probing of surface and bulk chemical compositions in a perovskite-type Ni catalyst. Surface and Interface Analysis, 52(12), 811–817.
Shende, V. S., Saptal, V. B., & Bhanage, B. M. (2019). Recent advances utilized in the recycling of homogeneous catalysis. The Chemical Record, 19(9), 2022–2043.
Shetty, A., Molahalli, V., Sharma, A., & Hegde, G. (2022). Biomass-derived carbon materials in heterogeneous catalysis: A step towards sustainable future. Catalysts, 13(1), 20.
Tavizón-Pozos, J. A., Chavez-Esquivel, G., Suárez-Toriello, V. A., Santolalla-Vargas, C. E., Luévano-Rivas, O. A., Valdés-Martínez, O. U., … & Rodriguez, J. A. (2021). State of art of alkaline earth metal oxides catalysts used in the transesterification of oils for biodiesel production. Energies, 14(4), 1031.
Tavizón-Pozos, J. A., & Cruz-Aburto, Z. G. (2024). A review of the use of SrO in catalysts for biodiesel production. Biofuels, Bioproducts and Biorefining, 18(2), 652–668.
Villarroel-Rocha, J., Barrera, D., Arroyo-Gómez, J. J., & Sapag, K. (2021). Insights of adsorption isotherms with different gases at 77 K and their use to assess the BET area of nanoporous silica materials. Adsorption, 27(7), 1081–1093.
Vogt, C., & Weckhuysen, B. M. (2022). The concept of active site in heterogeneous catalysis. Nature Reviews Chemistry, 6(2), 89–111.
Wang, H., Qian, X., & Liu, L. (2026). Role of alkali metal promoter in zeolite-encapsulated subnanometer metal catalysts. ACS Catalysis.
Yaghi, M., Chidiac, S., Awad, S., El Rayess, Y., & Zgheib, N. (2025). An overview of biodiesel production via heterogeneous catalysts: Synthesis, current advances, and challenges. Clean Technologies, 7(3), 62.
Yan, K., Liu, Y., Lu, Y., Chai, J., & Sun, L. (2017). Catalytic application of layered double hydroxide-derived catalysts for the conversion of biomass-derived molecules. Catalysis Science & Technology, 7(8), 1622–1645.
Yan, P., Zhang, X., Herold, F., Li, F., Dai, X., Cao, T., & Qi, W. (2020). Methanol oxidative dehydrogenation and dehydration on carbon nanotubes: Active sites and basic reaction kinetics. Catalysis Science & Technology, 10(15), 4952–4959.
Zhang, P., Liu, Y., Fan, M., & Jiang, P. (2016). Catalytic performance of a novel amphiphilic alkaline ionic liquid for biodiesel production: Influence of basicity and conductivity. Renewable Energy, 86, 99–105.
Zhang, Y., Duan, L., & Esmaeili, H. (2022). A review on biodiesel production using various heterogeneous nanocatalysts: Operation mechanisms and performances. Biomass and Bioenergy, 158, 106356.
Zhang, Z., Meng, P., Luo, H., Pei, Z., & Liu, X. (2024). Lewis acid-base site-assisted in situ transesterification catalysis to produce biodiesel. Catalysts, 14(10), 731.
Zhang, Z. H., Sun, Z., & Yuan, T. Q. (2022). Recent advances in the catalytic upgrading of biomass platform chemicals via hydrotalcite-derived metal catalysts. Transactions of Tianjin University, 28(2), 89–111.
Zheng, F., & Cho, H. M. (2025). Study on biodiesel production: Feedstock evolution, catalyst selection, and influencing factors analysis. Energies, 18(10), 2533.
Zuo, Z., Sha, Y., Wang, P., & Da, Z. (2024). From bench to industry, the application of all-inorganic solid base materials in traditional heterogeneous catalysis: A mini review. RSC Advances, 14(11), 7468–7489.
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