Green Synthesis, Characterization, and Evaluation of the Antimicrobial, Antioxidant, Hepatoprotective, and Nephrocurative Activities of Boswellia dalzielii–Chitosan Loaded Nanoparticles
DOI:
https://doi.org/10.33003/fjs-2026-1013-5577Keywords:
Boswellia Dalzielii, Chitosan Nanoparticles, Green Synthesis, Antimicrobial Activity, Antioxidant Activity, Hepatoprotective, NephrocurativeAbstract
This study successfully engineered B. dalzielii–chitosan nanoparticles (BDCNPs) as a green, multifunctional nanoplatform with validated therapeutic superiority over unloaded counterparts. Physicochemical synergy—evidenced by UV–Vis-confirmed phytochemical encapsulation, FTIR-demonstrated H-bonded phytocomplexation, SEM-visualized porous phytocoatings, and XRD-proven amorphization—enabled sustained bioactive delivery and enhanced cellular interaction.Biologically, BDCNPs delivered potent, broad-spectrum antimicrobial action (ZOI up to 21.6 mm), superior radical scavenging (IC₅₀ ~33 µg/mL), and robust organ protection. In hepatotoxicity, BDCNPs normalized liver enzymes, restored protein synthesis, and reversed centrilobular necrosis, rivaling silymarin. In nephrotoxicity, they attenuated creatinine/urea surges, rebalanced electrolytes, and regenerated tubular epithelium, matching vitamin E efficacy.These outcomes stem from dual chitosan–polyphenol mechanisms: membrane disruption (antimicrobial), ROS neutralization (antioxidant), and anti-apoptotic signaling (organ protection)—all amplified by nano-enabled bioavailability. BDCNPs represent a sustainable, biocompatible paradigm for integrative management of oxidative stress, infections, and drug-induced organ damage, with strong translational promise in resource-limited settings. Future work should explore in vivo pharmacokinetics, chronic toxicity, and clinical scalability.
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Copyright (c) 2026 Shehu Muazu Ahmad, Muhammad Sheshe Sadeeq, Ahmad Dini sabo Bashir, Safiyya M. Shehu
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