B-HEMATIN INHIBITION ACTIVITY OF THE METHANOL LEAF EXTRACT AND RESIDUAL AQUEOUS FRACTION OF FICUS ASPERIFOLIA

Authors

  • Ibrahim Doma Abdullahi
    Department of Pharmacology Bayero Univesity Kano
  • Abdullahi Hamza Yaro
    Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria.
  • Mustapha Ibrahim Gudaji

Keywords:

Antimalarial, Chloroquine, Ficus asperifolia, Heme-polymerization

Abstract

Chemotherapy is still regarded as the major intervention in fighting the malaria scourge despite the recent introduction of malaria vaccine. Screening of medicinal plants provides opportunities for the discovery of the potential drug molecules. Ficus asperifolia (Miq) family Moraceae has been traditionally employed in the treatment of many diseases including pain, fever and malaria. The aim of this study was to examine the anitmalarial activity of both the methanol leaf extract (MEFA) and residual aqueous fraction of Ficus asperifolia (RAF) through the determination of their heme polymerization inhibition ability. The powdered leaf was extracted using 70%

Author Biography

Abdullahi Hamza Yaro

HOD Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria.

Dimensions

Abdullahi, I. D., Umar H. Y., Suleiman U, B., Abdullahi R. A., Maitama A. Y., Abdullahi R. A and Yaro, A. H. (2023). Quantitative Determination of Phytochemical Constituents of Fractions Obtained from Ficus asperifolia Leaves Miq (Moraceae) and the Characterization of Compounds Identified in the Residual Aqueous Fraction; FUDMA Journal of Sciences Vol. 7 No.2, 330-343.

Abdullahi, I. D., Yaro, A. H and Nazifi, A. B. (2020). Anti-nociceptive and Anti-inflammatory Activities of Solvent Fractions of Methanol Leaf Extract of Ficus asperifolia miq. (Moraceae) in Murine Models; Nigerian Journal of Pharmaceutical Sciences Vol. 19 No.2, 25-37.

Akanbi O. M., Elekofehinti O., Olatokunbo A., Adejuyigbe A and Jegede A. (2018). Anti-malarial Activity of Total Saponins from Terminalia avicennioides and Its Effect on Liver and Haematological of Infected Mice. Drug Designing; 7: 2. DOI: 10.4172/2169-0138.1000161.

Akuodor, G.C., Anyalewech, N.A., Ikoro, N.C., Akpan, J.L., Megwas, U.A., Iwuanyanwu, T.C. (2010). Evaluation of Antiplasmodial Activity of Berlina grandiflora Leaf Extract Against Plasmodium berghei in Mice. African Journal of Microbiological Research; 4(21): 2211-2214.

Alshawsh, S.M., Mothana, R.A., Al-Shamaly, H.A., Alsllami, S.F. and Lindequist, U. (2007). Assessment of Antimalarial Activity Against Plasmodium falciparum and Phytochemical Screening of Some Yemeni Medicinal Plants. Ecam; 6:453-456.

Asanga Edet E., Eseyin Olorunfemi, Ebong Patrick, Igile Godwin,Thomas Paul S and Ebong A. (2017). Antiplasmodial Activity of Ethanol Extract and Fractions of Nauclea Latifolia Smith (Rubiacea) Roots. World J Pharm Sci ; 5(5): 106-118.

Ayoola G.A et al. (2008). Phytochemical Screening and antioxidant activities of some Selected Medicinal Plant used for malaria therapy in South-western Nigeria. Tropical Journal of Pharmaceutical Research; 7(3):1014-1019.

Published

30-04-2024

How to Cite

B-HEMATIN INHIBITION ACTIVITY OF THE METHANOL LEAF EXTRACT AND RESIDUAL AQUEOUS FRACTION OF FICUS ASPERIFOLIA. (2024). FUDMA JOURNAL OF SCIENCES, 8(2), 15-22. https://doi.org/10.33003/fjs-2024-0802-2161

Issue

Vol. 8 No. 2 (2024): FUDMA Journal of Sciences - Vol. 8 No. 2

Section

Research Articles
Copyright & Licensing

How to Cite

B-HEMATIN INHIBITION ACTIVITY OF THE METHANOL LEAF EXTRACT AND RESIDUAL AQUEOUS FRACTION OF FICUS ASPERIFOLIA. (2024). FUDMA JOURNAL OF SCIENCES, 8(2), 15-22. https://doi.org/10.33003/fjs-2024-0802-2161

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