TETRACARPIDIUM CONOPHORUM EXTRACT EXHIBITS ANTI-FATIGUE ACTIVITY IN RATS VIA REDUCED PROTEIN CATABOLISM, INCREASED ANTIOXIDANT STATUS AND DELAYED LACTATE ELEVATION

Authors

  • Ugochukwu Vincent Igbokwe
  • EZE EJIKE DANIEL
    DEPARTMENT OF PHYSIOLOGY, KABALE UNIVERSITY, UGANDA
  • Moses Dele Adams
  • Karima Mohammed Rabiu
  • Ezekiel Iliya
  • Prisca Ojochogu Ajeka
  • Adam Moyosore Afodun

Keywords:

Fatigue; Tetracarpidium conophorum; Euphorbiaceae; Swim endurance time; Lactate

Abstract

Thirty rats of both sexes were assigned into 5 categories of six animals apiece. Animals in the unadministered (control) group were placed on distilled water. Group 1M and Group 1F animals were administered 500 mg/kg body weight (b.w) of T. conophorum aqueous nut extract whereas animals in Group 2M and Group 2F were administered 750 mg/kg dosage of the extricate (0.5 ml) orally once daily for 32 days. Phytoconstituents present in the extract include: saponins, flavonoids, tannins, phenols and alkaloids. The extract at 750mg/kg b.w notably (p<0.05) raised extracellular glucose in masculine rats when matched with males that received 500 mg/kg b.w. The 500 mg/kg dose of the extract appreciably (p<0.05) elevated BUN in both sexes, but with reduction in both groups at 750 mg/kg b.w when juxtaposed with their respective untreated animals. The extract at 500 mg/kg b.w increased LDH activity in male group when compared with male rats that received 750 mg/kg dose. The 750-extract dosage did not statistically (p>0.05) alter LDH activity in both sexes. The extract at 500 and 750mg/kg b.w increased the 3rd‒6th swim in male rats. Substantive (p<0.05) rise in swimming endurance time was first noticed at the 2nd swim when matched up with the control and group treated 500 mg/kg b.w, in female rats. Sequel to these research findings, it is hypothesized that the anti-weakness effect of T. conophorum might be adduced to delayed increase in lactate and reduction in protein catabolism

Dimensions

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Published

01-07-2021

How to Cite

TETRACARPIDIUM CONOPHORUM EXTRACT EXHIBITS ANTI-FATIGUE ACTIVITY IN RATS VIA REDUCED PROTEIN CATABOLISM, INCREASED ANTIOXIDANT STATUS AND DELAYED LACTATE ELEVATION. (2021). FUDMA JOURNAL OF SCIENCES, 5(2), 225-235. https://doi.org/10.33003/fjs-2021-0501-608

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Vol. 5 No. 2 (2021): FUDMA Journal of Sciences - Vol. 5 No. 2

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Research Articles
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FUDMA Journal of Sciences

How to Cite

TETRACARPIDIUM CONOPHORUM EXTRACT EXHIBITS ANTI-FATIGUE ACTIVITY IN RATS VIA REDUCED PROTEIN CATABOLISM, INCREASED ANTIOXIDANT STATUS AND DELAYED LACTATE ELEVATION. (2021). FUDMA JOURNAL OF SCIENCES, 5(2), 225-235. https://doi.org/10.33003/fjs-2021-0501-608

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