ANALYSIS OF COMORBIDITY IN ENDOCRINE DISRUPTORS OF POLYCARBONATE PLASTICS AND HYPERGLYCAEMIC AGENT IN MALE WISTAR RATS

Authors

Keywords:

Polycarbonate plastic, Bisphenol, Streptozotocin (STZ), Endocrine disruptor

Abstract

Polycarbonate plastics, widely used in consumer products, contains bisphenol A (BPA), a compound with endocrine-disrupting properties. BPA exposure has been implicated in exacerbating metabolic disorders, including diabetes. Understanding its histological impact on diabetic patients is critical, as chronic exposure may amplify cellular damage. This study employs an animal model to investigate the effects of BPA on diabetic tissues, focusing on histological alterations. Thus, the aim of this research is to elucidate the potential risks of polycarbonate plastic exposure for diabetic individuals. A total number of Twenty male Wistar rats which average weight was 185g were used and randomly splitted into four groups with each group comprising of five rats. Group A served as the control group, Group B were induced with Bisphenol- A (100mg/kg), Group C were induced with STZ (100mg/kg) which served as diabetic group, Group D were induced with Bisphenol-A (100mg/kg) and STZ (100mg/kg) which served as diabetic and bisphenol group. Bisphenol administration was done orally and STZ administration done intraperitoneally. The findings of this study revealed the histological damage caused by bisphenol-A (BPA), highlighting the serious health risks it poses upon entering the body. Specifically, chronic BPA exposure in adult rats was shown to have observable adverse effects, including significant reproductive alterations that could potentially result in infertility. Additionally, BPA exposure led to a marked reduction in body weight and an increase in fasting blood glucose levels. Chronic exposure to bisphenol-A induces histological damage, reproductive alterations, body weight reduction, and elevated fasting blood glucose, posing significant health...

Dimensions

Cadmus, S. I. B., & Daramola, O. F. (2024). Responsible conduct of research: Animal care use and research ethics. African Journal of Biomedical Research, 23(SE2), 35–39. https://doi.org/10.4314/ajbr.v23iSE2.6

Farrugia, F., Aquilina, A., Vassallo, J., & Pace, N. P. (2021). Bisphenol A and type 2 diabetes mellitus: A review of epidemiologic, functional, and early life factors. International Journal of Environmental Research and Public Health, 18(2), 716. https://doi.org/10.3390/ijerph18020716

Malaisé, Y., Lencina, C., Cartier, C., Olier, M., Ménard, S., & Guzylack-Piriou, L. (2020). Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice. Environmental Health, 19(1), 93. https://doi.org/10.1186/s12940-020-00614-w

Mentor, A., Wänn, M., Brunström, B., Jönsson, M., & Mattsson, A. (2020). Bisphenol AF and bisphenol F induce similar feminizing effects in chicken embryo testis as bisphenol A. Toxicological Sciences, 178(2), 239–250. https://doi.org/10.1093/toxsci/kfaa152

Potrebić, M. S., Pavković, Ž. Z., Srbovan, M. M., Dmura, G. M., & Pešić, V. T. (2022). Changes in the behavior and body weight of mature, adult male Wistar Han rats after reduced social grouping and social isolation. Journal of the American Association for Laboratory Animal Science, 61(6), 615–623. https://doi.org/10.30802/AALAS-JAALAS-22-000032

Rossi, G., Dufrusine, B., Lizzi, A. R., Luzi, C., Piccoli, A., Fezza, F., Iorio, R., D’Andrea, G., Dainese, E., Cecconi, S., & Maccarrone, M. (2020). Bisphenol A deranges the endocannabinoid system of primary Sertoli cells with an impact on inhibin B production. International Journal of Molecular Sciences, 21(23), 8986. https://doi.org/10.3390/ijms21238986

Saha, S., Chant, D., Welham, J., & McGrath, J. (2005). A systematic review of the prevalence of schizophrenia. PLoS Medicine, 2(5), e141. https://doi.org/10.1371/journal.pmed.0020141

Schmucker, C., Eisele-Metzger, A., Meerpohl, J. J., Lehane, C., Kuellenberg de Gaudry, D., Lohner, S., & Schwingshackl, L. (2022). Effects of a gluten-reduced or gluten-free diet for the primary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews, 2022(2), CD013556. https://doi.org/10.1002/14651858.CD013556.pub2

Shen, J., Kang, Q., Mao, Y., Yuan, M., Le, F., Yang, X., Xu, X., & Jin, F. (2020). Urinary bisphenol A concentration is correlated with poorer oocyte retrieval and embryo implantation outcomes in patients with tubal factor infertility undergoing in vitro fertilisation. Ecotoxicology and Environmental Safety, 187, 109816. https://doi.org/10.1016/j.ecoenv.2019.109816

Struyf, T., Deeks, J. J., Dinnes, J., Takwoingi, Y., Davenport, C., Leeflang, M. M., Spijker, R., Hooft, L., Emperador, D., Domen, J., Tans, A., Janssens, S., Wickramasinghe, D., Lannoy, V., Horn, S. R. A., Van den Bruel, A., & Cochrane COVID-19 Diagnostic Test Accuracy Group. (2022). Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19. Cochrane Database of Systematic Reviews, 2022(5), CD013665. https://doi.org/10.1002/14651858.CD013665.pub3

Tomza-Marciniak, A., Stępkowska, P., Kuba, J., & Pilarczyk, B. (2018). Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies. Journal of Applied Toxicology, 38(1), 51–80. https://doi.org/10.1002/jat.3480

Wang, C., Liu, Z., & Xu, X. (2019). Bisphenol A exposure induces germ cell apoptosis and Sertoli cell dysfunction in rats. Toxicology Letters, 310, 49–56. https://doi.org/10.1016/j.toxlet.2019.05.013

Wei, J., Lin, Y., Li, Y., Ying, C., Chen, J., Song, L., Zhou, Z., Lv, Z., Xia, W., Chen, X., Xu, S., & Wang, C. (2011). Perinatal exposure to bisphenol A at low doses can predispose offspring to metabolic syndrome in adulthood. Endocrinology, 152(8), 3049–3061. https://doi.org/10.1210/en.2011-0045

Zhu, Q., Wang, M., Jia, J., Hu, Y., Wang, X., Liao, C., & Jiang, G. (2020). Occurrence, distribution, and human exposure of several endocrine-disrupting chemicals in indoor dust: A nationwide study. Environmental Science & Technology, 54(18), 11333–11343. https://doi.org/10.1021/acs.est.0c04299

Published

23-10-2025

How to Cite

Adegoke, A. A., Dare, B. J., Adekomi, D. A., Fatoki, J. O., Ajadi, T. O., Ebiwonjumi, A. S., Ojo, W. A., Ajayi, A. A., Ajayi, A. O., Oni, T. A., Ojo, O. G., Odutola, T. M., & Ogungbe, L. G. (2025). ANALYSIS OF COMORBIDITY IN ENDOCRINE DISRUPTORS OF POLYCARBONATE PLASTICS AND HYPERGLYCAEMIC AGENT IN MALE WISTAR RATS. FUDMA JOURNAL OF SCIENCES, 9(11), 123-128. https://doi.org/10.33003/fjs-2025-0911-4146

Issue

Vol. 9 No. 11 (2025): FUDMA Journal of Sciences - Vol. 9 No. 11

Section

Research Articles
Copyright & Licensing

Copyright (c) 2025 Adebiyi Aderinola Adegoke, B. J. Dare, D. A. Adekomi, J. O. Fatoki, T. O. Ajadi, A. S. Ebiwonjumi, W. A. Ojo, A. A. Ajayi, A. O. Ajayi, T. A. Oni, O. G. Ojo, T. M. Odutola, L. G. Ogungbe

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Adegoke, A. A., Dare, B. J., Adekomi, D. A., Fatoki, J. O., Ajadi, T. O., Ebiwonjumi, A. S., Ojo, W. A., Ajayi, A. A., Ajayi, A. O., Oni, T. A., Ojo, O. G., Odutola, T. M., & Ogungbe, L. G. (2025). ANALYSIS OF COMORBIDITY IN ENDOCRINE DISRUPTORS OF POLYCARBONATE PLASTICS AND HYPERGLYCAEMIC AGENT IN MALE WISTAR RATS. FUDMA JOURNAL OF SCIENCES, 9(11), 123-128. https://doi.org/10.33003/fjs-2025-0911-4146

Most read articles by the same author(s)