ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES OF TWO LIGANDS DERIVED FROM AMINO ACIDS AND 2 – IMINO – 1 – METHYLIMIDAZOLIDIN – 4 – ONE

Authors

  • Muhammad Manir
  • Gwaram N.S umaru musa yar'adua university katsina
  • Madaki U A Federal University Dutsinma

DOI:

https://doi.org/10.33003/fjs-2021-0504-702

Keywords:

antioxidant; antimicrobial; metal complexes; amino acids; ligands.

Abstract

Plant extracts are most of the time used for antioxidant and antimicrobial studies. The Present study was designed to evaluate the activity of metal complexes as antioxidant and against some selected bacterial and fungal isolates. The new metal complexes of Cr (III) and Zn (II) containing ligands derived from Tyrosine, Leucine and 2 – imino – 1 – methylimidazolidin – 4 - one  were selected. The test compounds were evaluated for their possible antioxidant activity through free radical scavenging activity via using 1,1 – diphenyl – 2 – picryl – hydrazyl (DPPH) method. All the complexes exhibited good to moderate activity with Cr (III) complex (CrL1) and (CrL2) as the best radical scavengers having the % inhibition value of 67.74 and 65.33 respectively. The complexes were also screened for their antimicrobial activities against two bacterial isolates and one fungal isolate (Streptococcus pneumoniae, Klebsiella pneumoniae and Aspergillus niger). The result showed that all the compounds have the moderate activity against the tested organisms.

Author Biographies

Gwaram N.S , umaru musa yar'adua university katsina

Department of pure and industrial chemistry. Senior Lecturer

Madaki U A, Federal University Dutsinma

Depatrment of Biochemistry and Molecularbiology. Msc student

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Published

2022-01-17

How to Cite

Manir, M., NURA SULEIMAN GWARAM, & Usman Ahmad Madaki. (2022). ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES OF TWO LIGANDS DERIVED FROM AMINO ACIDS AND 2 – IMINO – 1 – METHYLIMIDAZOLIDIN – 4 – ONE. FUDMA JOURNAL OF SCIENCES, 5(4), 81 - 89. https://doi.org/10.33003/fjs-2021-0504-702