GREEN SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF MIXED LIGAND COMPLEXES OF Co (II), Ni (II) and V(III) METALS USING SOME AMINO ACIDS AS LIGANDS
DOI:
https://doi.org/10.33003/fjs-2020-0404-471Keywords:
antibacterial, metal complexes, amino acids, mixed ligands, GrindingAbstract
Co (II), Ni (II) and V (III) metal complexes were synthesized mechanochemically using L-Leucine, L-Tyrosine and Creatinine as mixed ligands. The metals and the ligands were grounded using an agate mortar with a pestle. The compounds formed were characterized using their melting/decomposition temperature, solubility, magnetic susceptibility, conductivity measurement, Infrared analysis and scanning electron microscope (SEM). The Metal – ligand ratios were investigated via Job’s method of continuous variation. The shifts of bands (for instance 1693-1677 cm-1 to 1674-1607 cm-1) in C=O and the appearance of new bands in the complexes (683-669 and 713-750 cm-1 indicates the complexation. The lower conductivity measurement values (15.00 to 32.40) µS.cm-1 suggested the non-electrolytic nature of the complexes. The magnetic effective value of the metal complexes showed that all the three complexes are paramagnetic and octahedral. It was concluded that the amino acids (ligands) coordinated in a bidentate way through the nitrogen from the amino group and oxygen from carboxylate. The complexes were screened for their antimicrobial activities against two bacterial isolates (Streptococcus pneumoniae and Klebsiella pneumoniae). All the complexes exhibited good activity against the organisms
References
Akinpelu, D.A. and Onakoya, Z.T.M. (2006). Antimicrobial Activities of Medicinal Plants Used in Folklore. Remedies in South-western Nigeria. African Journal of Biotechnology, 7(5): 1078-1081.
Al- Amin M.A. (2013). Impact of Indiscriminate Land Uses in Species Abundance: Case Study of Silk Cotton Tree Ceibapentandra Colony at Southern Suburb of Zaria City. Nigeria. British Journal Of Environmental Sciences, 1 (1): 1-6.
Ali, A.A and Alquraini, F. (2006). Activities of antioxidants in plants under environmental stress. The lutein-Prevention and Treatment for Diseases. P.187-256.
Andre, C.M., Larondelle, Y. and Evers, D. (2010). Dietary Antioxidants and Oxidative Stress from a Human and Plant Perspective: A Review Current Nutrition & Food Science,6 (1): 2-12.
Anurag, K., Raghveer, I., Anumalik, Y., Nitika, G., Swadesh, K., Nikil, G., Santosh, K., Vinay, Y., Anuj, P. and Himanshu, G. (2014). Metabolites in Plants and Its Classification. World Journal of Pharmacy and Pharmaceutical Sciences, 4 (1): 287- 298.
Arif, I.A., Bakir, M.A., Khan, H.A., Al Farhan, A.H., Al Homaidan, A.A., Bahkali, A.H. Al Sadoon, M. and Shobrak, M. (2010). A Brief Review of Molecular Techniques to Assess Plant Diversity. International Journal of Molecular Sciences, 6: 2079–2096.
Bairwa, N. K, Neeraj, K.S. and Mishra, S.H. (2010). Protective Effect of Stem Bark of Ceibapentandra Linn. againstParacetamol-Induced Hepatotoxicity in Rats. Pharmacognosy Research, 2 (1): 26–30.
Bourgaud, F., Gravot, A.,Milesi, S. and Guntier, E. (2001): Production of Plant Secondary Metabolites: A Historical Perspective. Plant Science, 161: 839-851
Chandrasekaran, M. and Senthilkumar, V. (2011). Antibacterial and Antifungal Efficacy of Fatty Acid Methyl Esters from the Leaves of Sesuviumportulacastrum L. European Review for Medicinal and Pharmocological Sciences, 15: 775-780.
CHEMIK, (2014). Fatty Acids in Vegetable Oils and Their Importance in Cosmetic Industry. Sci. Tech.,68 (2): 103-110.
Daffre, S., Bulet, P., Spisni, A., Ehret-sabatier, L., Rodrigues, E.G. and Travassos, L.R. (2008). Bioactive Natural Peptides. In: Atta-ur-Rahman (Ed.) Studies in Natural Products Chemistry, 35: 597-691.
Djomeni-Dzeufiet, P.D., Tedong, L.,Asongalem, E.A., Dimo, T., Sokeng, S.D. and Kamtchouing, P. (2006). Hypoglycaemic Effect of Methylene Chloride/methanol Root Extract of CeibaPentandra in Normal and Diabetic Rats. Indian Journal of Pharmacology, 38 (3): 194.
Edeoga H.O and Eriata, D.O. (2001). Alkaloid, Tannin and Saponin Contents of Some Medicinal Plants. Journal of Medicinal and Aromatic Plant Sciences, 23: 344-349.
Edeoga,H.O., Okwu, D.E, and Mbsaebie, B.O. (2005). Phytochemical Constituents of Some Nigerian Medicinal Plants. African Journal of Biotechnology, 4 (7): 685-688.
Firn, R. (2010). Nature’s Chemicals. Oxford University Press, Oxford, p. 74-75.
Hawkes, J. (1992). In: Harris, P. (Ed). The Potato Crop. 2nd ed. Chapman-Hall, London, p. 13-64.
Ioana, P., Narcisa, E.B. and Sultana, N.O.P. (2014). Squalene- Natural Resources and Applications. Famacia, 62: 842-850.
Justin, N.K, Edmond, S.A.R. and Xin, H. (2014). Plant Secondary Metabolites: Biosythesis, Classification, Function and Pharmacological Properties. Journal of Pharmacy and Pharmacology, 2: 377.
Kang, J., Lee, S., Kang, S., Kwon, H.N., Park, J.H., Kwon, S.W., Park, S. (2008). NMR-based Metabolomics Approach for the Differentiation of Ginseng (Panax ginseng) Root from Different Origins. Archives of Pharmaceutical Research, 31: 330-336.
Kar, A. (2007). Pharmacognosy and Pharmacobiotechnology (Revised-Expanded Second Edition). New Age International Limited Publishers, New Delhi. p. 332-600.
Kreis, P. and Mosandi, A. (1992). Chiral Compounds of Essential Oils. Part XI. Simulteneous Stereo Analysis of Lavandula Oil Constituents. Flavor and Fragrance Journal, 7: 187-193.
Madziga H.A., Sanni, S. and Sandade U.K. (2010). Phytochemical and Elemental Analysis of AcalyphaWilkesiana Leaf. Journal of American Sciences, 6 (11): 510-514.
Martinez, M.J.A., Lazaro, R.M., delOlmo, L.M.B. and Benito, P.B. (2008). Anti-Infectious Activity in the Anthemideae Tribe. In: Atta-ur- (Ed) Studies in Natural Products Chemistry, 35: 445-516.
Mary, A.L. (1987). Final Report on the Safety Assessment of Oleic acid, Lauric acid, Palmitic acid and Stearic acid. Journal of the American College of Toxicology, 6 (3): 387.
Noreen, Y., El-Seedi, H., Perera, P. and Bohlin, L. (1998). Two New Isoflavones from CeibaPentandra and Their Effect on Cyclooxygenase-catalyzed Prostaglandin Biosynthesis. Journal of Natural Products, 61 (1): 8-12.
Okoye, F.B.C and Osadede, O.P. (2009). Study on the Mechanism of Anti-Inflammatory Activity of the extracts and fractions of Alchormea floribunda leaves. Asian Pacific Journal of TropicalMedicne, 2 (3): 7- 14.
Oleszek, W. and Marson, A. (2000). Saponins in Food and Medicinal Plants. Kluwer Academic Publishers. New York, p. 1-95.
Osuntokun, O.T., Ayodele, A.O., Adeoye, M.I. and Odufunwa, A.E. (2014). Assessment of Antimicrobial and Phytochemical Properties of Ceibapentandra Leaf and Bark Extracts of Ceibapentandra on Selected Clinical Isolates Found in Nigerian Teaching Hospital. Journal of Bacteriology and Mycology, 4 (1): 00079.
Pajor, M and Sun, N.N. (2013). Nonsteroidal Anti-Inflammatory Drugs and Other Anthranilic acid Inhibitors of Hepatitis C NS5B Polymares; Journalof Medicinal Chemistry, 50: 2108-2116.
Poongothai, A. Sreena, K. P. Sreejith, K. Uthinalinggam, M. and Annapoorani, S.(2011). Preliminary Phytochemicals Screeninng of FicusBasemosalinn bark. International Journal of Pharmacy and Biological Science, 2: 432-433.
Rao, K.V., Sreeramulu, K., Gunasekar, D. and Ramesh, D. (1993). Two New Sesquiterpene Lactones from CeibaPentandra. Journal of Natural Products, 56 (12): 2041–2045.
Ravi, K.C., Rao, D.B., Sirisha, N. and Rao, T.R. (2015). Assessment of Phytochemicals and Antioxidant Activities of Raw and Germinating CeibaPentandra (Kapok) Seeds. Journal of Biomedical Research, 29 (5): 414-419.
Salim, K., Rajeev, K.S. and Malik, Z.A. (2011). Assessment of Phytochemical Diversity in Phyllanthusamarus using HPTLC Fingerprints. Indo Global Journal of Pharmaceutical Sciences, 1 (1): 1-12.
Samuni-Blank, M., Izhaki, I., Dearing M. D., Gerchman, Y., Trabelcy, B., Lotan, A., Karasov, W. H., and Arad, Z. 2012. “Intraspecific Directed Deterrence by the Mustard Oil Bomb in a Desert Plantâ€. Current Biology, 22 (13): 1218-1220.
Sandhya, B., Thomas, S., Isabel, W. and Shenbagarathai, R. (2006). Complementary and Alternative Medicines, 3: 101-114.
Sarker, S.D. and Nahar, L. (2007). Chemistry for Pharmacy Students General, Organic and Natural Product Chemistry. England: John Wiley and Sons, p. 283-359.
Saurabh, P., Manila, B., Niraj, T., Sonal, P. and Bansal, Y.K. (2015): Secondary Metabolites of Plants and their Roles, Overview. Current Trends in Biotechnology and Pharmacy, 9 (3): 293-304
Shamsuddeen, U.,Ameh, J.B.,Oyeyi, T.I and Dantata, A.A. (2009). Study on the Phytochemical and In Vitro Antibacterial Activity of Some Spice Extracts on Some Bacteria Isolated from Meat Products. Bayero Journal of Pure and Applied Sciences, 2 (1): 102-103.
Stamp, N. (2003). “Out of the Quagmire of Plant Defense Hypotheses.†The Quarterly Review of Biology, 78 (1): 23-55.
Thrane, U. (2001). “Development in the Taxonomy of Fusarium Species Based on Secondary Metabolites.†In: Fusarium: Paul E. Nelson memorial symposium,edited by B.A. Summerell. St. Paul, Minnesota: APS Press, p. 29-49.
Tiannian, S., Bamba, T. andFususaki, E. (2010). Pyrolysis GC-MS based metabolite fingerprinting for quality evaluation of commercial Angelica acutiloba roots. Journal of Bio Sciences, 109 (1): 89-93.
Waterman, P.G. (1992). “Roles for Secondary Metabolites in Plants.†In Proceedings of the 171st Ciba FoundationSymposium on Secondary Metabolites: Their Functionand Evolution, 255-75.
Wiklund, P. and Bergman, J. (2006). The Chemistry of Anthranilic acid. Current Organic Synthesis, 3: 379-402.
Zhang, Y.J., Gan, R.Y., Li, S., Zhou, Y., Li, A.N., Xu, D.P. and Li, H.B. (2015). Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases. Molecules, 20 (12): 21138–21156.
Published
How to Cite
Issue
Section
FUDMA Journal of Sciences
