IMPACT OF MAGNETIC RESONANCE IMAGING ON HEMATOLOGICAL PARAMETERS ON ALBINO MICE
Abstract
Magnetic resonance imaging (MRI) is a non-invasive technique that uses strong magnetic fields and radiofrequency radiation, to measures behaviour of atomic nuclei inside the body, producing signals that are used to create images. The interactions between the biological systems and magnetic fields present in MRI, concerning changes in hematological parameters are not understood. This research investigated the effects of MRI on hematological parameters in albino mice. 30 male albino mice were divided into two groups, A (control) and B (exposed), each consisting of 15 mice. Mice in group B were exposed to a 1.5 T MRI scanner once a week for 30 minutes for 3 weeks. After the first exposure 5 mice from the exposed and 5 mice from the control were deeply sedated. This was repeated in the second and third exposure. Ministry of Health in Oyo State approved all protocols for animal experimentation. Data were expressed in mean ± standard error (S.E.) and analyzed using GraphPad Prism. First week of exposure indicated a significant increase in packed cell volume, neutrophils, lymphocytes, monocytes of the exposed group except for white blood cells which decreased. There was significant decrease in packed cell volume and lymphocytes of the exposed group except for white blood cells and Neutrophil which increased, monocytes were not significant in the second week. Third week indicated significant increase in white blood cell, lymphocytes, monocytes except for packed cell volume and Neutrophil which decreased. Thus, the hematological parameters of albino mice are negatively impacted by MRI exposure.
References
Al-Qadi, S. H. Z., Al_Dulamey, Q. K., Abed, M. A. and Mehuaiden, A. K. (2023). Effect of Static Magnetic Field on some Hematological Parameters of Human AML Leukemia: in vitro. Rafidain Journal of Science, 32(3):32-40. DOI: 10.33899/rjs.2023.180274 DOI: https://doi.org/10.33899/rjs.2023.180274
Dantzer, R. (2018). Neuroimmune interactions: from the brain to the immune system and vice versa. Physiological reviews, 98(1), 477-504. https://doi.org/10.1152/physrev.00039.2016 DOI: https://doi.org/10.1152/physrev.00039.2016
Dhabhar, F. S., Malarkey, W. B., Neri, E., and McEwen, B. S. (2012). Stress-induced redistribution of immune cells—From barracks to boulevards to battlefields: A tale of three hormones–Curt Richter Award Winner. Psychoneuroendocrinology, 37(9), 1345-1368. https://doi.org/10.1016/j.psyneuen.2012.05.008 DOI: https://doi.org/10.1016/j.psyneuen.2012.05.008
Ding, J., Chen, P., and Qi, C. (2024). Circadian rhythm regulation in the immune system. Immunology, 171(4), 525-533. https://doi.org/10.1111/imm.13747 DOI: https://doi.org/10.1111/imm.13747
Fardela, R., Rena, S. R., Maulida, A., and Diyona, F. (2023). Magnetic Resonance Imaging (MRI) Safety in Pregnant (A Literature Review). Jurnal Ilmiah Fisika FMIPA Universitas Lambung Mangkurat, 19(3), 236-246 https://doi.org/10.1016/j.ecoenv.2020.111085 DOI: https://doi.org/10.20527/flux.v19i3.14796
Franco, J. (2020). Magnetic resonance imaging safety. Journal of Radiology Technology, 91(4): 343-356 https://doi.org/10.1016/j.05.070
Ghadimi-Moghadam, A., Mortazavi, S.M.J., Hosseini-Moghadam, A., Haghani, M., Taeb, S., Hosseini, M.A., Rastegariyan, N., Arian, F., Sanipour, L. and Aghajari, S. (2018). Does Exposure to Static Magnetic Fields Generated by Magnetic Resonance Imaging Scanners Raise Safety Problems for Personnel? Journal of Biomedical Physics Engineering. 8, 333–336. DOI: 10.22086/jbpe. v0i0.653
Hani, M., Abdelsalama, and Mohammed E. (2018). The Influence of Magnetic Fields on Selected Physiological Parameters of Blood and Tissues in Mice. International Journal of Advanced Research in Biological Sciences.5(11):149-158. http://dx.doi.org/10.22192/ijarbs.2018.05.11.018 DOI: https://doi.org/10.1101/497990
Hartwig, V., Virgili, G., Mattei, F., Biagini, C., Romeo, S.; Zeni, O., Scarfi, M. R., Massa, R., Campanella, F., Landini, L., Gobba, F., Modenese, A. and Giovannetti, G. (2021). Occupational exposure to electromagnetic fields in magnetic resonance environment: an update on regulation, exposure assessment techniques, health risk evaluation, and surveillance. Medical & biological engineering & computing, 1-24. DOI:10.1007/s11517-021-02435-6 DOI: https://doi.org/10.1007/s11517-021-02435-6
Lauridsen, C. (2019). From oxidative stress to inflammation: Redox balance and immune system. Poultry science, 98(10), 4240-4246. https://doi.org/10.3382/ps/pey407 DOI: https://doi.org/10.3382/ps/pey407
Manso Jimeno, M., Vaughan, J. T., and Geethanath, S. (2023). Superconducting magnet designs and MRI accessibility: A review. NMR in Biomedicine, 36(9)-4921. https://doi.org/10.1002/nbm.4921 DOI: https://doi.org/10.1002/nbm.4921
Maulood, K. A. (2018). Assessment of some hematological, biochemical parameters and cardiac biomarker levels in patients with ischemic heart disease in Erbil city. ZANCO Journal of Pure and Applied Sciences, 30(2): 86-93 DOI: 10.18 869/psj.16.3.67 DOI: https://doi.org/10.21271/ZJPAS.30.2.11
McRobbie, D.W. (2020). Essentials of MRI safety. Wiley-Blackwell, Hoboken, New Jersey, US, 35: 32-88 https://doi.org/10.1016/j.03.058
Mustafa, B. T., Yaba, S. P. and Ismail, A. H. (2020). Experimental Evaluation of the Static Magnetic Field Effect on White Blood Cells: In Vivo Study. Materials Science Forum, Trans Tech Publications Ltd, 1002: 412-419. DOI: http://dx.doi.org/10.21271/zjpas DOI: https://doi.org/10.4028/www.scientific.net/MSF.1002.412
Nagase, H., Ueki, S., and Fujieda, S. (2020). The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: Asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis. AllergologyInternational, 69(2),178-186. https://doi.org/10.1016/j.alit.2020.02.002 DOI: https://doi.org/10.1016/j.alit.2020.02.002
Pai, A., Shetty, R., Hodis, B., and Chowdhury, Y. (2023). Magnetic Resonance Imaging Physics. In: Stat Pearls Publishing, Treasure Island 33(23)-1990. https://europepmc.org/article/NBK/nbk564320
Serwaan, J., Abdullah, A., Qusay, K., Al-Dulamey, M. and Ahmed, A. (2023). Study of the Effect of Magnetic Resonance on Some Blood Parameters of Smoking Addicts of All Kinds. International Journal of Scientific Research in Science and Technology, 10(4):519-530. https://doi.org/10.32628/IJSRST52310454 DOI: https://doi.org/10.32628/IJSRST52310454
Simpson, R. J., Campbell, J. P., Gleeson, M., Krüger, K., Nieman, D. C., Pyne, D. B., and Walsh, N. P. (2020). Can exercise affect immune function to increase susceptibility to infection? Exercise immunology review, 26,8-22 https://www.ncbi.nlm.nih.gov/pubmed/32139352.
Suppan, E., Pichler, G., Binder-Heschl, C., Schwaberger, B., and Urlesberger, B. (2022). Three physiological components that influence regional cerebral tissue oxygen saturation. Frontiers in Pediatrics, 10, 913-223. https://doi.org/10.3389/fped.2022.913223 DOI: https://doi.org/10.3389/fped.2022.913223
Wang, S., Luo, J., and Lv, H. (2019). Safety of exposure to high static magnetic fields (2 T–12 T): a study on mice. European Radiology 29:6029-6037. DOI:10.1007/s00330-019-06256 DOI: https://doi.org/10.1007/s00330-019-06256-y
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