SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF SCHIFF BASE DERIVED FROM 4-METHYL-o-PHENYLENEDIAMIE AND 2-HYDROXNAPTHALDEHYDE AND ITS METAL (II) COMPLEXES
Schiff base of 4-methyl-o-phenylenediamine and 2-hyroxy-1-napthaldehyde was synthesized and was used to prepare some metal (II) complex by refluxing with Metal (II) chloride ions. The ligand and its complexes were characterized by melting point and decomposition temperature, FTIR, solubility, magnetic susceptibility, conductivity measurement and elemental analysis. The IR spectral data revealed that, the Schiff base coordinated to the respective metal(II) ion through the azomethine nitrogen and phenolic oxygen due to the shifting of the azomethine band Ï…(C = N) from 591cmâ€“1 to 1603 and 1581cm-1 in the spectra of the complexes. The band at 567 and 563cm-1 were due to Ï…(Mâ€“N), and 729-752cmâ€“1 due to Ï…(Mâ€“O) and the infrared spectra of the metal(II) complexes showed strong bands 3443 and 3363cmâ€“1 suggesting the presence of coordinated water in the metal complexes. Molar conductance values determined 9.17 and 10.04Wâ€“1cm2molâ€“1 showed that, the complexes were non-electrolytes. The ligand and its metal (II) complexes are not soluble in water and most organic solvents except DMF and DMSO. The melting point of the ligand and the decomposition temperatures of the metal (II) complexes were 243 and 224oC, which indicated their good thermal stability. The magnetic moment values of the metal (II) complexes obtained were 5.65 and 5.22BM for Mn(II) and Fe(II) complexes. This positive values indicated that they were paramagnetic. The elemental analysis suggested a metal to ligand ratio of 1:2. The antibacterial and antifungal test carried out on the ligand and its metal (II) complexes sowed moderate activity.
Abbas S.A., Munir, M., Fatima, A., Naheed, S. & Ilyas, Z. (2010). Synthesis, Characterization and Biocidal studies of Some Transition Metal Complexes Ccontaining Tetra dentate and bi-dentate Schiff's Base. European Journal of life sciences. 1(2),37.
Brown, D.H. & Smith, W.E. (1990). Enzyme Chemistry-Impact and Applications. Chapman and Hall, London, 13.
Byeongâ€“Goo, J., Chaeâ€“Dyong, R., Heeâ€“Name, C., Kiâ€“Hyung, C. and Yohngâ€“Kook, C. (1996). Synthesis and Characterization of Schiff Base Derived from 2-hydroxyl-1-napthaldehyde and Aliphatic Diamines. Journal of the Korean Chemical Society, 17(8), 687 â€“ 693.
Chandra, S.& Sangeetika, S. (2004). EPR and electronic spectrum studies on copper(II) complexesof some N-O donor ligands. Journal of Indian Chemistry. Society, 81, 203-206.
Cozzi, P.G. (2004). Metal-Salen Schiff's base complexes in catalysis: practical aspects. Chemical Society Reviews, 33, 410-421.
Da Silva, C.M., Silva, D.L., Modolo, L.V., Alves, R.B., Resende, M.A., Mart C.V.B. &FÃ¡tima, A. (2011). Schiff'sBases: A short review of their antimicrobial activities. Journal of Advanced Research, 2,1â€“8.
Gehad, G. M., Mohamed, M. O. & Ahmed, M. H. (2005). Metal Complexes of Schiff Bases: Preparation, Characterization, and Biological Activity. Turkish Journalof Chemistry, 30, 361â€“382.
Khetani, Y.K., Agarwal S.C., Madnawat, S. P. & Ram N. (2015). Synthesis,Characterization andAntimicrobial Studies of Some Transition Metal Complexes of Schiff Bases, Research Journalof Chemical Science, 2(4), 68-71.
Munde, A. S., Jagdale, S. M., Jadhav, T. K.&Chondhekar, J. Serb. Chem.. Soc. Dalton Trans. 9, 1348, 2009.
Nakamoto, K.(1978). Infrared Spectra and Raman Spectra of Inorganic and Coordination compound, John Wiley & Sons, New York (1978) google scholar
Spinu, M., Sunil, J., Vatsala, P. & Uma, V. (2009). Biologically active Co(II), Ni(II), Cu(II) andMn(II) Complexes of Schiff Bases derived from Vinyl aniline and Heterocyclic Aldehydes. International Journal of Chem. Tech. Research.,1(2), 225-232.
Yushaâ€™u, M. &Salisu, F.U. (2011).Inhabitory activity of detariummicrocarpum extracts on some Clinical bacterial isolates. Biological and Environmental Science Journal for the Tropics,8(4), 113-117.
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