LIVER PROFILE CHANGES AMONG MALARIA PARASITE INFECTED PATIENTS
Abstract
Hepatic dysfunctions are part of the pathological effect of malaria infection among patients. This dysfunction is characterized by increase in liver enzyme activities. In this study, the effect of malaria parasites on liver enzymes among patients attending University Clinic, Federal University Dutsin-Ma, North-Western Nigeria is reported. Blood samples were collected from 118 patients and were examined for parasites using standard methods. Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) activities were determined using Randox enzymes kits. Out of the 118 examined, 107 (90.68%) were positive for malaria parasites. Prevalence of parasite showed significant association with age groups of patients (P = 0.000), with 6 – 15, 36 – 45, and 46 - 55 years having the highest prevalence of 100% each, while 26 – 35 years had the lowest prevalence of 79.31%. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly higher in the severe group than in the mild and negative groups, with ALT (P = 0.002) and AST (P = 0.02) having significant difference. Only ALT (P = 0.004) had significant difference with age groups of patients. This study revealed very high prevalence of
malaria among patients visiting the University Clinic and that malaria infection has effect on hepatic functions, and the level of dysfunction is determined by parasite loads/intensity.
References
Akanbi OM (2015). The influence of malaria infection on kidney and liver function in children in Akoko area of Ondo state, Nigeria. Journal of Parasitology and Vector Biology 7(8): 163-168.
Anyasor GN, Olorunsogo OO (2011). Evaluation of selected biochemical parameters in renal and hepatic functions following oral administration of artesunate to albino rats. Researcher 3(7).
Aundhakar S., Prajapati P, Prajapati S, Aundhakar A, Kothia D, John D, Shrisath A, Khatri M (2017). Study of Clinical and Hematological Profile of Plasmodium vivax Malaria in a Tertiary Care Hospital in Western Maharashtra, International Journal of Scientific Study, 5(3): 257-260.
Auta T, Runka JY, Bawa JA, Sa’adatu SK (2016). Haemoprevalence of malaria and haematological parameters of febrile patients in a hospital in Dutsin-Ma Town, North Western Nigeria. Biosciences Research in Today’s World, 2:8 – 14.
Bawa JA, Auta T, Liadi S (2014). Prevalence of Malaria: Knowledge, Attitude and Cultural Practices of Pregnant Women in Katsina Metropolis, Nigeria. European Scientific Journal 10(21): 148 – 167.
Burtis C, Ashwood E, Border B (2001). Liver Functions: In: Tietz Fundamental of clinical Chemistry: 5th Edn. Saunders Company, pp: 748-770.
Deshwal R (2012). Clinical and Laboratory Profile of Hospitalized Malarial Patients: An Agra-Based Study. Journal of the Association of Physicians of India 64(8): 44-47.
Edington GM (1967). Pathology of malaria in West Africa, British Med. J., 1: 715-718.
Ezechukwu C, Ekejindu I, Ugochuklwu E, Oguatu M (2004). Congenitally acquired malaria in hyper-endemic area. A Cohot study, Trop. J. Med. Res. 8 (2): 44.
Giboney, L., 2000. Mildly elevated liver transaminase levels in the asymptomatic patients. Am. Fam. Phys., 43: 28-35.
Jlarike AE, Emuveyon EE, Idogun SF (2002). Pitfalls in the interpretation of liver parenchymal and membranous enzymes results. In: Preclinical P. falciparum and malaria in the Nigeria Environment. Nig. Clin. Med., 10 (2): 21-27.
Klonis N, Creek DJ, Tilley L (2013). Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins. Current Opinion in Microbiology 16(6): 722-727.
Melhotra B (1997). Haematological manifestation of Malaria. Indian Journal of Haematology and Blood Transfusion 1997; 15- 40.2.
Ogbadoyi EO, Tsado RD (2009). Renal and Hepatic Dysfunction in Malaria Patients in Minna, North Central Nigeria. Online J Health Allied Scs. 8(3):1-6.
Roll Back Malaria (2008). Global Malaria Action Plan. 2008, (http://www.rbm.who.int/gmap/index.html)
Runka YJ, Jibia AB, Janaidu S, Nana AB (2015). A field survey on the assessment of awareness about contagious bovine pleuropneumonia (CBPP) in rural pastoral communities of Dutsinma Region, Katsina State, Nigeria. Sci. J. Vet. Adv. 4(1):1-12.
Sharma M, Nand N, Kumar H., Suman L (2012). Evaluation of Liver Functions in Falciparum Malaria, Journal of International Medical Sciences Academy, 25(4): 229-230.
Uzuegbu UE and Emeka CB (2011). Changes in Liver Function Biomarkers among Malaria Infected Patients in Ikeja Lagos State, Nigeria, Current Research Journal of Biological Sciences 3(3): 172-174.
Walter BJ, and Davis JE (1976). Malaria parasite, Historical background. 3rd Edn. W.B. Saunders. Medical Parasitology pp: 275.
Wasnik PN, Manohar TP, Humaney NR, Salkar HR (2012). Study of Clinical Profile of Falciparum Malaria in a Tertiary Referral Centre in Central India. Journal of the Association of Physicians of India, 60:33-36.
Wilaratna P, Looareesuwan S, Charoenlarp P (1994). Liver profile changes and complications in jaundiced patients with falciparum malaria. Trop. Med. Parasitol., 45: 298- 302.
World Health Organization (2015). "Achieving the malaria MDG target: reversing the incidence of malaria 2000-2015." (PDF). UNICEF.
Amorim VL, Gomes CM, Lira HL, Franca KB, Ferreira HC, (2007). Bentonites from Boa Vista, Brazil: Physical, Mineralogical and Rheological Properties. Material Research, 7(4): 583-593.
Apugo-Nwosu TU, Mohammed-Dabo IA, Ahmed AS, Abubakar G, Alkali AS, Ayilara SI, Nwobi BE (2011). Modeling Rheological Behaviour of UbakalaBentonite as Bingham Plastic and Power Law Fluids. Annual International Conference, Workshop & Exhibition of the Chemical Society of Nigeria, held at University of Ilorin, 19th - 23rd, September.
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