• S. M. Jodi
  • S Omoniyi
  • H. Y. Ungo-kore
  • Y. B. Ngwai
Keywords: Acacia nilotica, Honey, Antifungal activity, ethanolic leaves


The increasing threat of fungal resistant to current antifungal agents underscores the need for an alternative source of antifungal agents. This study was designed to investigate the antifungal activity of honey and Acacia nilotica extracts against four important fungal pathogens (Candida albican, Aspergillus niger, Trychophyton rubrum and Trychophyton mentagrophyte). The in vitro antifungal activity of honey, ethanolic leaves and stem-bark extracts from Acacia nilotica L was studied using agar well diffusion and micro broth dilution techniques. The honey and ethanolic crude leaf extract exhibited considerable fungistatic activity against the four fungal isolates. The maximum diameter zones of inhibition of 18.50 mm was observed in Candida albican with ethanolic leaves extracts while a minimum of 16.00 mm diameter zones of inhibition was found on Trychophyton rubrum and Trychophyton mentagrophyte. There was no activity against all the fungal isolates when ethanolic stem-bark extract was used. A maximum diameter zones of inhibition of 20.00 mm diameter was observed in Trychophyton rubrum with 50 %v/v of honey concentration, while a minimum 13.50 mm diameter zone of inhibition was found in Trychophyton mentagrophyte. The MIC and MFC of the extract against the fungal isolates ranged from 15.63 - 250.00 mg/ml and 31.25 - 250.00mg/ml for ethanolic leaves extract, 6.25-50% and 12.5-50% for honey, 32-128.00µg/ml and 32 - 128.00 µg/ml for fluconazole respectively. The in vitro antifungal activity revealed a considerable antifungal activity of honey and ethanolic leaves extracts of A. nilotica L. than stem-bark extract


Al-Fatimi, M., Wurster, M., Schröder, G., & Lindequist, U. (2007). Antioxidant, antimicrobial and cytotoxic activities of selected medicinal plants from Yemen. Journal of Ethnopharmacology, 111(3), 657–666.

Awuchi, C. G. (2019). Medicinal plants: the medical, food, and nutritional biochemistry and uses. International Journal of Advanced Academic Research, 5(11), 220–241.

Cavalier-Smith, T. (2018). Kingdom Chromista and its eight phyla: a new synthesis emphasising periplastid protein targeting, cytoskeletal and periplastid evolution, and ancient divergences. Protoplasma, 255(1), 297–357.

Gandhiraj, R., & Soman, K. P. (2014). Modern analog and digital communication systems development using GNU Radio with USRP. Telecommunication Systems, 56(3), 367–381.

Gnat, S., Łagowski, D., Nowakiewicz, A., & Dyląg, M. (2019). Tinea corporis caused by Trichophyton equinum transmitted from asymptomatic dogs to two siblings. Brazilian Journal of Microbiology, 1–6.

Jain, N., Sharma, M., Joshi, S. C., & Kaushik, U. (2018). Chemical composition, toxicity and antidermatophytic activity of essential oil of Trachyspermum ammi. Indian Journal of Pharmaceutical Sciences, 80(1), 135–142.

Khurana, A., Sardana, K., & Chowdhary, A. (2019). Antifungal resistance in dermatophytes: Recent trends and therapeutic implications. Fungal Genetics and Biology, 132, 103255.

Mandal, M. D., & Mandal, S. (2011). Honey: its medicinal property and antibacterial activity. Asian Pacific Journal of Tropical Biomedicine, 1(2), 154–160.

Moro, D. D., & David, O. M. (2021). Antimicrobial resistance among fungi from patients with urinary tract infections in Ojo, Lagos, Nigeria. GSC Biological and Pharmaceutical Sciences, 14(3), 254–264.

Prakash, B., Kujur, A., Yadav, A., Kumar, A., Singh, P. P., & Dubey, N. K. (2018). Nanoencapsulation: An efficient technology to boost the antimicrobial potential of plant essential oils in food system. Food Control, 89, 1–11.

Richardson, M., & Lass-Flörl, C. (2008). Changing epidemiology of systemic fungal infections. Clinical Microbiology and Infection, 14, 5–24.

Satish, S., Raghavendra, M. P., & Raveesha, K. A. (2008). Evaluation of the antibacterial potential of some plants against human pathogenic bacteria. Advances in Biological Research, 2(3–4), 44–48.

Sinkar, S. R., & Samarth, V. D. (2019). Medicinal plants used for the treatment of various skin disorders by a rural community in warud region of Maharashtra. The Pharma Innovation Journal, 8(5), 791–794.

Tilston, E. L., Deakin, G., Bennett, J., Passey, T., Harrison, N., Fernández, F., & Xu, X. (2020). Effect of fungal, oomycete and nematode interactions on apple root development in replant soil. CABI Agriculture and Bioscience, 1(1), 1–18.

Tripathi, P., & Singh, A. (2020). Acacia nilotica, Albizia saman, Azadirachta indica: Ethanobotany and Medicinal Uses. Modern Research in Botany Vol. 1, 96–103.

White Jr, J. F., Kingsley, K., Harper, C. J., Verma, S. K., Brindisi, L., Chen, Q., Chang, X., Micci, A., & Bergen, M. (2018). Reactive oxygen defense against cellular endoparasites and the origin of eukaryotes. In Transformative Paleobotany (pp. 439–460). Elsevier.
How to Cite
JodiS. M., OmoniyiS., Ungo-koreH. Y., & NgwaiY. B. (2022). ANTIFUNGAL ACTIVITIES OF HONEY AND ACACIA NILOTICA EXTRACTS. FUDMA JOURNAL OF SCIENCES, 4(1), 779 - 783. Retrieved from

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