EVALUATION OF 67Ga CROSS SECTIONS USING EXIFON CODE FOR MEDICAL APPLICATIONS

  • Ahmed Rufai Usman
  • A. A. Ahmad
Keywords: Cross sections, Excitation function, 67Ga, Nuclear reaction, Nuclear reaction model

Abstract

Radioisotopes play very important roles in nuclear medicine for imaging and therapeutic applications. In the present studies, model calculation of excitation function for production of 67Ga radioisotope was performed using the EXIFON code, a nuclear reaction cross sections theoretical model code, for the reaction 65Cu(α, 2n)67Ga. The work was performed in the incident alpha energy range of 0 - 40 MeV. Similarly, the Q-value software (interface) was used for the calculation of reaction threshold and Q-value energies of the reaction of interest and were respectively found to be 14.97 MeV and -14.10 MeV. The calculated excitation function has a peak value of 1025 mb around 25 MeV incident energy. The results from the EXIFON code were compared with the experimentally measured cross sections data retrieved from IAEA database, the EXFOR database, as well as the theoretical data from Talys code via its library, the TENDL-2019. Our results partially agree with the theoretical data from Talys code (via the TENDL-2019 library) within the investigated energy region. The results however overestimated the measured (experimental) data and only agree in shape of the excitation function. The present work does not consider the effect of shell structure during the execution of the EXIFON model code. This work could be of importance to the developers and users of nuclear reaction model codes for new developments and enhancements of the existing codes, as well as to serve as a rough guide for experimentalists during production of radioisotopes for nuclear medicine applications

References

Agassi, D., Weidenmulter, H. A. & Mantzouranis, G. (1975). Generalized Exciton Model for the Description of Preequilibrium Processes. Phy. Rep. 22, 145.

Ahmad I., Fatima Salman Koki, and Yahaya Ibrahim Yola Yahaya (2019). Calculation of Reaction Cross-section of Proton-induced Nuclear Reactions on Iodine-127 Isotope. Bayero Journal of Pure and Applied Sciences 11(1), 308 – 314.

Ahmad I, Yola, Y.I., Koki, F.S. (2017). Evaluation of Excitation Functions of Reactions Used in Production of Some Medical Radioisotopes. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 6 (3), 290 – 303.

Alharbi, A. A., & Azzam, A. (2012). Theoretical calculations of the reaction cross-sections for proton-induced reactions on natural copper using ALICE-IPPE code. Applied Radiation and Isotopes, 70(1), 88-98. doi:https://doi.org/10.1016/j.apradiso.2011.09.009

Art, O. and Aytekin, H. (2015). Calculations of Excitation Functions of Proton, Alpha and Deuteron Induced Reactions for Production of Medical Radioisotopes 122 – 125I. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 345, 1-8.

Chad-Umoren Y. F. and Ebiwonjumi, B. F. (2014). Determination of Nuclear Reaction Cross-sections for Neutron-Induced Reactions in Some Odd – A Nuclides. Advances in Physics Theories and Applications, 32, 55-69.

Dauda A. (2011). Nuclear model calculation of excitation functions of Neutron induced reactions on the structural materials of the miniature neutron source reactor, M.Sc. thesis submitted to the post graduate school, Ahmadu Belleo University, Zaria, Nigeria. Retrieved on 8th May, 2022 from http://kubanni.abu.edu.ng/jspui/bitstream/123456789/503/1/NUCLEAR%20MODEL%20CALCULATION%20OF%20EXCITATION%20FUNCTIONS%20OF%20NEUTRON%20INDUCED%20REACTIONS%20ON%20THE%20STRUCTURAL%20MATERIALS%20OF%20THE%20MINIATURE%20NEUTRON%20SOURCE%20REACTOR..pdf

Dauda, A., Jonah, S.A., Hassan, M and Muhammad, B.G. (2017). Nuclear model calculation of excitation functions of neutron induced reactions on the structural materials of the miniature neutron source reactor (Nigeria Research Reactor 1). World Scientific News 66, 86-96.

Feshbach, H., Kerman, A. & Koonin, S. E. (1980). The statistical theory of multi-step compound and direct reactions. Ann. of Phy, 125 (2) 429-476

Griffin, J. J. (1967). A Unique Classification of Nuclear States, Phy. Lett. 248, 5

Hauser, W. and Feshback H. (1952); Inelastic scattering of neutrons, Physics Rev. 87, 366 - 373. http//doi.org/10.1016/j.apradiso.2007.11.013

Herman, M., Capote, R., Carlson, B., Obložinský, P., Sin, M., Trkov, A., . . . Zerkin, V. (2007). EMPIRE: nuclear reaction model code system for data evaluation. Nuclear Data Sheets, 108(12), 2655-2715.

Hod, K., Tova, Y., Gold, O., Harari, S. F., Guindy, M., Shpilberg, O., . . . Tavor, S. (2021). The Pattern of Use of PET/CT Scans in the Clinical Management of Chronic Lymphocytic Leukemia. Clinical Lymphoma Myeloma and Leukemia, 21(8), 558-563.

Jonah, S. A. (2004). Shell Structure Effect in Neutron Cross Section Calculation by Theoretical Model Code. Nigerian Journal of Physics 16(2).

Kalka H. (1991); Exifon- A Statistical Multistep Reaction Code Report, Technische University Dresden Germany.

Kalka, H. (1992). Statistical Multistep Reaction Model for Nuclear Data. In: Qaim, S.M. (eds) Nuclear Data for Science and Technology. Research Reports in Physics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58113-7_248

Kalka H., Torgman, Lien H.N. Lopezs, R and Seegler, D. (1990). Description of (n, p) and (n, 2n) Activation Cross Section for Medium Mass Nuclei within Statistical Multi Theory Z. Physics. Atomic Nuclei, 335, 163 – 171.
Manhas, N. S., Salehi, S., Joyce, P., Guermazi, A., Ahmadzadehfar, H., & Gholamrezanezhad, A. (2020). PET/Computed Tomography Scans and PET/MR Imaging in the Diagnosis and Management of Musculoskeletal Diseases. PET Clinics, 15(4), 535-545.

Muhammed, K., Onimisi, M.Y. and Jonah, S.A. (2011). Investigation of the Shell Effect on Neutron Induced Cross Section of Actinides. Journal of Nuclear & Particle Physics, 1, 6-9

Murata, T. (1997). Modification of EXIFON code and analysis of 16O+n reactions in En=20-50 MeV. JAERI-Conf--97-005, Fukahori, Tokio (Ed.), Japan

Khandaker, M. U., Haba, H., Otuka, N., & Usman, A. R. (2014). Investigation of (d,x) nuclear reactions on natural ytterbium up to 24 MeV. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 335(0), 8-18.
Koning, A.J., Rochman, D. (2012). Modern nuclear data evaluation with the TALYS code system. Nucl. Data Sheets, 113, 2841–2934.

Koning A. J., Rochman D., Sublet J., Dzysiuk N., Fleming M., Vander-Marck S. (2019).
TENDL: complete nuclear data library for innovative nuclear science and technology,
Nuclear Data Sheets, 155, 1–55.

Koumarianou, E., Slastnikova, T.A., Pruszynski, M., Rosenkranz, A.A., Vaidyanathan, G., Sobolev, A.S., Zalutsky, M.R. (2014). Radiolabeling and in vitro evaluation of 67Ga-NOTA-modular nanotransporter – A potential Auger electron emitting EGFR-targeted radiotherapeutic. Nuclear Medicine and Biology, 41(6), 441–449

Navin, A., Tripathi, V., Blumenfeld, Y., Nanal, V., Simenel, C., Casandjian, J. M.,. . Tryggestad, E. (2004). Direct and compound reactions induced by unstable helium beams near the Coulomb barrier. Physical Review C, 70(4), 044601.

NuDat 2.6. (2011). Radionuclide decay data sourse. Retrieved 14/07/2021, from National Nuclear Data Center, Brookhaven National Laboratory, USA http://www.nndc.bnl.gov/nudat2/

Ogawa, Y., Abe, K., Hata, K., Yamamoto, T., & Sakai, S. (2021). A case of pulmonary tumor embolism diagnosed with respiratory distress immediately after FDG-PET/CT scan. Radiology Case Reports, 16(3), 718-722.

O'Donoghue, J. A., & Wheldon, T. E. (1996). Targeted radiotherapy using Auger electron emitters. Phys Med Biol, 41(10), 1973-1992.

Otuka, N., Dupont, E., Semkova, V., Pritychenko, B., Blokhin, A. I., Aikawa, M., . Zhuang, Y. (2014). Towards a More Complete and Accurate Experimental Nuclear Reaction Data Library (EXFOR): International Collaboration Between Nuclear Reaction Data Centres (NRDC). Nuclear Data Sheets, 120, 272-276.

Otuka, N., Lalremruata, B., Khandaker, M. U., Usman, A. R., & Punte, L. R. M. (2017). Uncertainty propagation in activation cross section measurements. Radiation Physics and Chemistry. doi:10.1016/j.radphyschem.2017.01.013

Polster, D. and Kalka, H. (1991). Short Note Fission within a Statistical Multistep Model. Zeitschrift für Physik a handbook of Hadrons & Nuclei, 424, 423-424.
https://doi.org/10.1007/BF01560648

QCalc. (2016). Q-value Calcultor. Retrieved 13/04/2018, from National Nuclear Data Centre, NNDC http://www.nndc.bnl.gov/qcalc/

Talou, P., Chadwick, M.B., Dictrech, F., Herman, M., Kawanu, T., Koning, A., Ohion Zinky, P. (2004). Sub Group A Nuclear Model Codes. Report of the Sixteenth Meeting of the WPEC. France, May 26 – 28

Tarkanyi, F., Ditroi, F., Takacs, S., Hermanne, A., & Ignatyuk, A. V. (2014). New data on activation cross section for deuteron induced reactions on ytterbium up to 50 MeV. Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms, 336, 37-44.

Usman, A. R., Khandaker, M. U., & Haba, H. (2017). Cyclotron production of 48 V via nat Ti(d,x) 48 V nuclear reaction; a promising radionuclide. Journal of Physics: Conference Series, 860(1), 012029.

Usman, A. R., Khandaker, M. U., Haba, H., Murakami, M., & Otuka, N. (2016). Measurements of deuteron-induced reaction cross-sections on natural nickel up to 24 MeV. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 368, 112-119.

Usman, A. R., Khandaker, M. U., Haba, H., Otuka, N., & Murakami, M. (2017). Excitation functions of alpha particles induced nuclear reactions on natural titanium in the energy range of 10.4 – 50.2 MeV. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 399, 34-47.

Usman, A. R., Khandaker, M. U., Haba, H., Otuka, N., & Murakami, M. (2020). Production cross sections of thulium radioisotopes for alpha-particle induced reactions on holmium. Nuclear Inst. and Methods in Physics Research B, 469, 42-48.

Usman, A. R., Khandaker, M. U., Haba, H., Otuka, N., Murakami, M., & Komori, Y. (2016). Production cross-sections of radionuclides from α-induced reactions on natural copper up to 50MeV. Applied Radiation and Isotopes, 114, 104-113.

Van de Wiele, C. (2008). CHAPTER 7 - Nuclear Medicine Imaging With an Emphasis on Spinal Infections. In C. W. Slipman, R. Derby, F. A. Simeone, T. G. Mayer, L. H. Chou, D. A. Lenrow, S. Abdi, & K. R. Chin (Eds.), Interventional Spine, (pp. 89-93). Edinburgh: W.B. Saunders.
Published
2022-07-01
How to Cite
UsmanA. R., & AhmadA. A. (2022). EVALUATION OF 67Ga CROSS SECTIONS USING EXIFON CODE FOR MEDICAL APPLICATIONS. FUDMA JOURNAL OF SCIENCES, 6(3), 113 - 118. https://doi.org/10.33003/fjs-2022-0603-987