ISOLATION, CHARACTERIZATION AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF DIARRHEAGENIC ESCHERICHIA COLI (DEC) AMONG CHILDREN ATTENDING SOME SELECTED HOSPITALS WITHIN KADUNA METROPOLIS
DOI:
https://doi.org/10.33003/fjs-2022-0602-936Keywords:
Diarrhoea, Diarrhoeagenic E.coli (DEC), Kaduna, Multidrug resistance (MDR)Abstract
Diarrhoea has been associated with significant morbidity and mortality, ranked the second cause of death in children aged 0 to 5 years. Bacteria, viruses, protozoa, and helminths have all been implicated in diarrhoea, however rotavirus and diarrhoeagenic E. coli (DEC) are the most common cause. This study aimed to determine the antibiotic susceptibility pattern of diarrheagenic Escherichia coli isolated from children 0-5 years attending selected hospitals in Kaduna metropolis. A total of 264 stool samples were collected from children attending four selected hospitals in Kaduna metropolis. Standard culture procedures and molecular techniques such as PCR and 16s rRNA were employed in isolation and characterization of diarrhoeagenic E. coli from the stool samples. The study established a prevalence of 24.2% for diarrheagenic Escherichia coli, and all the isolates demonstrated multiple antimicrobial resistance index (MARI) of 0.5 and above, and showed significant resistance against augmentin (100%), amoxacillin (100%), ampicillin-cloxacillin (ampiclox) (100%), erythromycin (100%), gentamycin (100%), cefoxitin (100%), cefuroxime (95%), ceftriazone (95%) and ceftaxidime (85%). The least (60%) resistance was observed against imipenem. The study concluded that antibiotics have not been very effective in the treatment of E. coli-related diarrhoea. The study, therefore, recommends the implementation of programmes geared towards good hygiene, good nutrition and good health
References
Acharya, V. V., Shin, H. S. and Yorulmazer, T. (2011). Crisis Resolution and Bank Liquidity. The Review of Financial Studies, 24, 2166 – 2205.
Basel Committee on Banking Supervision (2004). International Convergence of Capital Measurements and Capital Standard: A revised Framework. Bank for International Settlements: 14th November, 2021.
Basel Committee on Banking Supervision (2011). Basel III. A Global Regulatory Framework for More Resilient Banks and Banking Systems: 14th November, 2021.
Borio, C., Furfine, C. and Lowe, P. (2001). Procyclicality of the Financial system and Financial Stability: Issues and Policy options. Bank of International Settlements (BIS), 1, 1 – 57.
Central Bank of Nigeria. Statistical Bulletin. Abuja. Lagos.
Debajyoti, G. R., Bindya, K. and Swati, K. (2013). Basel I to Basel II to Basel III: A Risk Management Journey in Indians Banks. AIMA Journal of Management and Research, 7(2/4), 474 – 497.
Fouche, C. H., Mukuddem – Petersen, J. and Petersen, M. A. (2006). Continuous – time Stochastic Modeling of Capital Adequacy Ratio for Banks. Applied Stochastic Model in Business and Industry, 22(1), 41 – 71.
Grant, E. M. and Peter, J. W. (2014). An Optimal Portfolio and Capital Management Strategy for Basel III Compliant Commercial Banks. Journal of Applied Mathematics, Vol. 2014, Article ID 723873, 11 pages.
Jungbacker, B., Koopman, S. J. and Van – der – Wel, M. (2011). Maximum Likelihood Estimation for Dynamic Factor Models With Missing Data. Journal of Economic Dynamics and Control. 35(8), 1358 – 1368.
Lowe, P. (2002). Credit Risk Measurement and Procyclicality. Bank for International Settlements Working Paper. 116: 1 – 17.
Mukuddem – Petersen, J. and Petersen, M. A. (2008). Optimizing Asset and Capital Adequacy Management in Banking. Journal of Optimization Theory and Applications. 137(1), 205 – 230.
Mukuddem – Petersen, J., Petersen, M. A., Schoeman, I. M. and Tau, B. A. (2007). An Application of Stochastic Optimization Theory to Institutional Finance. Applied Mathematical Sciences, 1, 1357 – 1384.
Mulaudzi, M. P., Petersen, M.A. and Schoeman, I. M. (2008). Optimal Allocation Between Bank Loans and Treasuries with Regret. Optimization Letters, 2(4), 555 – 566.
Nicolo, G. D., Gamba, A. and Lucchetta, M. (2012). Capital Regulation, Liquidity Requirements and Taxation in a Dynamic Model of Banking. IMF Working paper. Eltville
Nigeria Stock Exchange. Lagos. Nigeria.
Subranmanian, A. and Yang, B. (2012). Dynamic Prudential Regulation. Working Paper, Georgia State Universtity.
Ugo Obi – Chukwu (2014). Meaning of Capital Adequacy Ratio as Defined by Central Bank of Nigeria: 26th November, 2021. https://www.nairametrics.com/2014/04/03/meaning-of-capital-adequacy-ratio-as-defined-by-the-central-bank-of-nigeria/
Vaughan, V. A. (2014). Estimation of Discretely Sampled Continuous Diffusion Processes with Application to Short – Term Interest Rate Models. PhD Thesis, University of Johannesburg.
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