SYNTHESIS, GRAVIMETRIC ANALYSIS AND ANTIMICROBIAL STUDIES OF TRANSITION METALS (Cu(II), Zn(II)) COMPLEXES OF SCHIFF DERIVED FROM 2-HYDROXY-1-NAPHTHALDEHYDE AND 2-AMINO-3-METHYLPYRIDINE
Abstract
The interaction between 2-hydroxy-1-naphthaldehyde with 2-amino-3-methylpyridine give an orange- yellow Schiff base and its metals complexes of Cu (II) and Zn (II) were green and dark-green respectively, both Schiff base and metals complexes were characterized using different analytical techniques such as melting point, solubility test, conductivity, measurement, magnetic susceptibility measurement, IR spectroscopy and TGA. The Schiff base and its respective metal complexes showed a sharp melting point and are soluble in ethanol, dimethylsulfuroxide and methanol but insoluble in water and slightly soluble in other solvent. The conductivity value obtained revealed that the synthesized complexes are non-electrolytes while an octahedral geometry was suggested for all complexes based on the data obtained from magnetic susceptibility analysis. The IR results revealed bands at 1596 cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. 747 cm-1, 773 cm-1, for (M-N) while 465 cm-1, 469 cm-1 for (M-O) bands in the spectra of the complexes supporting coordination of Schiff base to respective metals. The thermo-gram (TGA) data of all complexes, exhibited three stages of decomposition which include loss of water, decomposition of the complexes and the formation of metal (II) oxide as the final product/residue. The in vitro antimicrobial screening of Schiff base and its metals complexes showed that they are potent antimicrobial agents against the tested microorganisms
References
Agwara, M. O., Ndifon, P. I., Ndosiri, N. B., Paboudam, A. G., Yufanyi, D. M. and Mohamadou, A., (2010) Synthesis, characterization and antimicrobial activities of Co(II), Cu(II) and Zn(II) mixed – Ligand complexes containing 1,10-phe nanthroline and 2, 2’- bipyridine,â€Bulletin of the Chemical Society of Ethiopia. 24 (3) 383-389.
Abdelsalam, M.M, Ali M.H., Bassem, H. H., Bader, M.A., Gamal, A., and Zaghloul I.E (2019):Green Synthesis, Spectral, thermal characterization and biological activities of Schiff base ligand derived from 3-amino-1,2,4-triazol and its metals complexes:Organic and Medicinal Chem IJ 8(3)
Aliyu H.N, Ado. I (2011): Synthesis, of Mn(II) and Ni(II) complexe with schiff base derived from 2-aminobenzoic acid and salicyldehyde: Biokemistri vol. 23 no. 1
Aliyu, H.N. and Sani, U., (2011). Synthesis, Physicochemical Characterization and Microbial Activity of N, N’ Bis (2 – hydroxyl – 1-Naphthalyl) propylenediiminato Metal (II) Complexes. Journal of Asian scientific research. 1(8) Pp.399-406
Ashraf M. A., Mahmood K., Wajid A. (2011); Synthesis, Characterization and Biological Activity of Schiff Bases IPCBEE, 10 PP 1-7
Arulmurugan a., Halen P., Venkatraman B. R.(2010) Biological application of schiff and
Its complexes: A review Rasayan journal of chemistry 3(3) Pp385-410
Annapoorani, S., and Krishnan, C.,(2013). Synthesis and spectroscopic studies of trinuclear N4 Schiff base complexes international. Journal of Chemical and Technology Research.5 (1), 180–185.
Bharat, A M, Pratik, N. D and Pratik, B. T (2015). Synthesis of Schiff base and their transition metal complexes, characterization and application. International Journal of Science,Technology and Management, 04(1): 642-652.
Boghaei D. M., Askarizadeh E. and Bezaatpou, A., ( 2008). Molecular and BiomolecularSpectroscopy. Spectrochim. Acta Part A, 69, 624–628.
David T. S., Balakumar S. and suganthi, S., (1999). Effect of Complexation on the ions mobility of some 3-d metal ions. International journal of apply chemistry 12:38-49
Fessenden R.J. and Fessenden, J.S.(1998). Organic Chemistry, Brooks/Cole Publishing Company, USA,
Figgis, B. N.; Lewis, J. In Lewis, J., Wilkins, R. G Eds. (1960). Modern coordi nationchemsitry, Interscience Publishers Inc.: New york. pp400 - 454
Govindaraj,S., Veerachamy, A.,andChinnasamy R.P.,(2015).Synthesis, characterization and in vitro antimicrobial activity of some 1-(substitutedbenzylidene)-4-(4-(2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl)semicarbazide Derivatives. Journal of Saudi Chemical Society19, 3–11
Hine 1.J. and Yeh, C.Y. Journal of American Chemical Society 89 (1967) 2669
Imran, M, Liviu M, Shoomaila, L, Zaid, M, Imtiaz, N, Sana, S. Z and Surrya, F (2010). Antibacterial Co(II), Ni(II), Cu(II) and Zn(II) Complexes with Biacetyl- Derived Schiff Bases. Journal ofSerbian Chemical Society, 75(8):1075–1084.
Jamuna, K, Harikishore, D, Reddy K, Naresh, B K, Venakata, D K R and Seshaiah, K (2011). Synthesis, Characterization and Biological Activity of Cu(II) and Ni(II) Complexes of 3-Hydroxy-4-(Pyridine-2-yl-Methylene Amino)benzoic Acid. Oriental Journal of Chemistry, 27(3):1141-1147.
Kowol, C. R. R. Trondl, P. Heffeter, V. B. Arion, M. A. Jakupec, A. Roller, M. Galanski, W. Berger, B. K. Keppler, J. Med. Chem. 52 (2009) 5032.
Kuete, V, Mbaveng, A. T., Tsaffack. M., Beng, V. P., Etoa, F. X., Nkengfack, A, E., Meyer, J.J and Lall, N., (2008). Antitumour, Antioxidant and Antimicrobial Activities of BersamaEngeleriana (Melianthaceae).Journal of Ethnophamacology 15:494-501
Kumar, N, Pratima, S, Aastha, P and Prasad, AVGS (2013). Synthesis and characterization of some new shiff bases. International Journal ofChemical and Pharmaceutical Sciences 23(2):231-236.
Lawal, A., Obaleye, J.A., Adediji, J.F., Amolegbe S.A., Bamigboye, M.O., Yunus- Issa, Mt., (2014). Synthesis, Characterization and Antimicrobial Activities of Some Nicotinamide – metal Complexes, Journal of Applied Science and Enviromental Management 18 (2): 205-208
Lewis G.P., (1954). The Importance of Ionization In The Activity of Sympathomimetic Amines. British Journal of Pharmacology 9, 488.
Obaleye, J. A., Adediji, J.F., Olayinka, E.T. and Adebayo, M. A.,(2009). ‘Synthesis, antimicrobial potential and toxicological activities of Ni (II) complex of mefloquine hydrochloride. Research in Pharmaceutical Biotechnology. 1 (1), 009-015.
Ogbannia, S. O., Enwuru,; N. V., Oyemenem, G. A., Oyedele; G. A., and Enwuru; C. A.,(2008). Photochemical Evaluation and antibacterial profile of Treculia Africana Deene Bark Extract on Gastrointestinal Bacteria pathogens. African Journal of Biotechnology 7(10): 1383-389
Ogunniran KO, Ajanaku KO, James OO, Ajani OO, Nwinyi CO, Allensela MA.. Fe (III) and Co (II) Complexes of Mixed Antibiotics: Synthesis, Characterization Antimicrobial Potential and their effect on Alkaline Phosphatase Activities of (2008)
Oladipo, M.A, Woods J.A.O, Odunola O.A. 2005. Synthesis, Vibrational Spectra and Magnetic Properties of Cobalt (II), Nickel (II) and Copper (II) Complexes of Barbituric Acid. Sci. Foc., 10(1): 49-52. https://scholar.google.com/scholar?hl
Osowole AA, Kolawole GA, Fagade OJ. 2008. Synthesis, Characterization and Biological Studies on Unsymmetrical Schiff base Complexes of Nickel(II), Copper(II) and Zinc(II) and Adducts with 2,2’- dipyridine and 1, 10 phenanthroline. J. Coord. Chem., 61: 1046-1049.
Orvig C, Abrams MJ (1999) Medicinal inorganic chemistry: introduction. Chem Rev 99(9): 2201–2204.
Patil , C. J. Manisha C. P, and Mrunmayee C. Patil:(2017) Studies on Synthesis of Aromatic Schiff Bases: Part-II. Synthesis,Characterization and Biological Evaluation of Ketimines from Benzophenone with Substituted-anilines ACTA
Putaya A.N. Habila, Naomi P. Ndahi, Hauwa S. Bello, Grema Mala Adekunle A. Osunlaja And HussainiGarba (2020): Synthesis, characterization and antimicrobial analysis of Schiff bases of o-phenylenediamine and 2-aminopyridine-3-carboxylic acid with ofloxacin and their metal (II) complexes, Int. J. Biol. Chem. Sci. 14(1): 263-278
Sani U and Iliyasu S M (2018) Synthesis, Characterization And Antimicrobial Studies On Schiff Base Derived From 2- Aminopyridine and 2- Methoxybenzaldehyde and Its Cobalt (Ii) and Nickel (Ii) Complexes Bayero Journal of Pure and Applied Sciences 11(1):pp 214 – 219 ISSN 2006 – 6996
Sabry, A. A, Saad, R F, El-Dine, A and Abdel- Hady M (2016). Synthesis Characterization and Antimicrobial Activity of Schiff Base (E)-N-(4-(2- Hydroxybenzylideneamino)phenylsulfonyl)acetamideMetalComplexes.American Journal of Analytical Chemistry, 7:233-245.
Sani S, Siraj, I,T. (2020): Mechanochemical Synthesis, Characterization, Thermal Analysis and Antimicrobial Studies Of Co (Ii) Complexes Nigerian Research Journal of Chemical Science Vol. 8 (1)
Satya, P., Tuli, G. D.,Basu, S.K. and Madan, R. D., (2006). Advanced Inorganic chemistryChand S. and Company. Pp 33, 40-50.
Sobola, Abdullahi O., Gareth M. Watkins And Bernadus Van Brecht (2018): Synthesis, characterization and biological study of Cu(II) complexes of aminopyridine and (aminomethyl)pyridine Schiff bases, J. Serb. Chem. Soc. 83 (7–8) 809–819
Copyright (c) 2021 FUDMA JOURNAL OF SCIENCES
This work is licensed under a Creative Commons Attribution 4.0 International License.
FUDMA Journal of Sciences
