DNA VACCINES: CHALLENGES AND APPROACHES
Abstract
Since the discovery of the first vaccine about 200 years ago, improvement in vaccine development approaches has occurred over the years. Most notably, the emergence of DNA vaccines. DNA vaccines can evoke both humoral and cell mediated immunity, they are safe and have several advantages over other vaccines types. Despite this, poor immunogenicity produced by DNA vaccines in humans has called for novel strategies. This review highlight ways to improve the efficacy of DNA vaccines through plasmid modification, delivery systems, prime boost and addition of adjuvants. The review also discusses the potential of DNA vaccine in pandemic settings such as that of corona virus disease 2019 (COVID-19)
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