PREVALENCE AND PATTERN OF SEVERE MALARIA AMONG CHILDREN IN TWO GENERAL HOSPITALS, JIGAWA STATE- NIGERIA
Abstract
The prevalence and pattern of presentation of severe malaria differ from one area to another, in one age group and gender. A descriptive cross sectional study of children between the ages of one month and fourteen years with symptoms of severe malaria was conducted between July and December 2018 in Dutse and Birnin Kudu Local Government Area of Jigawa State. Venous blood samples were used for parasitological, hematological and biochemical examination following standard procedures. Thick and thin blood films were prepared, stained and examined at x100 magnification. A total of 172 children were considered in which, 73/167(43.7) children had severe malaria. Children less than 5 years of age had the highest percentage of severe malaria (47.1%; 95% CI = 39.5 to 54.7). Hyperpyrexia, prostration, hyper parasitemia and multiple convulsions were the commonest presentations. While metabolic acidosis, jaundice, hypoglycemia and respiratory distress were the least presenting features, no child presented spontaneous bleeding or shock. Furthermore, 21/73 children with severe malaria had only one feature of severity, 32/73 (43.8) had two features of severity, while 14/73 (19.2) of the children had up to three features. Only 4/73 (5.5) children had four of the features of severity. Chi-square analysis showed significant difference (P <0.05) in prostration and multiple convulsions among children less than and above 5 years. The prevalence of severe malaria in less than five years old is high; hence care givers should present symptoms early to the hospital in order to prevent progression to severe life threatening malaria.
References
Adebola, E.O., Olufunmi, F., James, O. O., Felix, O. A., Olugbemiro, S. (2007). Increasing burden of childhood severe malaria in a Nigerian tertiary hospital: implication for control. Journal of Tropical Paediatric 53(3):185-9. doi: 10.1093/tropej/fmm002
Adulugba O.A, Amali, O. Ikpa, F. T. Manyi M. M. and Obisike, V. U. (2020). Studies on Plasmodium falciparum Infection Rates among Patients Attending General Hospitals in Benue State, Nigeria. International Blood Research & Reviews11(3): 1-8, 2020; Article no.IBRR.59986ISSN: 2321– 7219
Al‑Taiar A, Jaffar S, Assabri A, Al‑Habori M, Azazy A, Al‑Mahdi N, et al. (2006) Severe malaria in children in Yemen: Two site observational study. BMJ ;333:827.
Amodu-Sanni, M , Ahmed, H, Jiya, N.M., Yusuf, T., Sani, U.M., Isezuo, K.O., Ugege, M.O., Mikailu, A. J. (2019). Prevalence and clinical forms of malaria among febrile hiv-infectedchildren seen at usmanu danfodiyo university teachinghospital,sokoto, Nigeria, Afr., J. Infect. Dis. (2020) 14 (1): 24-32
Araoye, M. (2004). Sample size calculation in Araoye MO (ed). Research methodology with statistics for health and social sciences, Ilorin.Nathadex (Publ).
Bassat Q, Guinovart C, Sigaúque B, Aide P, Sacarlal J, Nhampossa T, BardajÃA, Nhacolo A, Macete E, Mandomando I, Aponte JJ, Menéndez C, Alonso PL, 2008.Malaria in rural Mozambique. Part II: children admitted to hospital. Malar J; 7:37-39.
Cheesbrough, M. (2000). District laboratorypractice manual in Tropical Countries pt 2. Cambridge University press.
Desta K.M. (2000).Pattern of severe and complicated malaria in children Admitted to Gondar Medical College hospital, Ethiopian Journal of Health Development 200;.16(1):53- 59.
Edelu, B.O., Ndu, I.K., Igbokwe, O.O. and Iloh, O.N. (2018). Severe falciparum malaria in children Enugu, South East Nigeria. Nigerian Journal of Clinical Practice, 21:1349-1355.
Ekpenyong, E. A., and Eyo, J. E., (2008).Malaria control and treatment strategies among school children in semi-urbantropical communities. West Indian Medical Journal, 57(5): 456 – 461.
Garba, B.I, Muhammad, A.S. Edem, B.E Adeniji, A.O Aghadueki, S., Kolawole, T. and Adelakun, M.B (2014). Prevalence and pattern of severe malaria seen in children at a specialist hospital in Gusau, Nigeria. ISSN: 0976-9633 (Online) Journal DOI:10.7439/ijbr CODEN:IJBRFA.
Gupta BD, RK Maheshwari and M Karunakaran 2006. Malaria. BI Publications Pvt. Ltd. NewDelhi, India. 2: 254 pp.
Ikome, L., Ndamukong, K. and Kimbi, H. (2002). Prevalence and case control study of cerebral malaria in Limbe the South-West Cameroon. African Journal of Health Science, 9:61–7.
Imbert P, Candito D, Ka S, Sartelat I, Baujat G, Rogier C, 1997. Severe malaria in children from the seasonal low transmission zone of Senegal: effect of age on the clinical manifestations. Dakar Med 1997; 42(1):44-48
Iragbogie Al-Mustapha, I., Hayatu, A., Maimuna, O., Yusuf, T., Umara, Y. and Yusuf, O. (2018) Clinical profile and outcome of paediatric severe malaria in a north-eastern Nigerian tertiary hospital. 28(2): 1-9, 2017; Article no.IJTDH.38818ISSN: 2278–1005, NLM ID: 101632866
Nwankwo BO, Okafor JO.2009. Effectiveness of insecticide–treated bed nets inmalaria prevention among children aged 6months to 5 years in a rural community in Imo state,Nigeria.International Journal of Tropical Medicine; 4(1): 41-49.
Mockenhaupt F.P, Enrhardt S, Burkardt J, Bosomtue S.Y, Laryea S, AnemanS.D, Otchwemeh R.N, Cramer J.P, Dietz E, Gellert S, Brenzle U, 2004. Manifestations and outcome of severe malaria in children in northern Ghana. Am J Trop Med Hyg;71(2):167-172.
Magallon-Tejada A, Machevo S, Cistero P, Lavstsen T, AideP, Rubio M, et al. (2016 ). Cytoadhesion to gC1qR through Plasmodium falciparum Erythrocyte Membrane Protein 1 in Severe Malaria. PLOS Pathogen, 12(11):232-245. Available from: https: //doi.org/10.1371/journal. ppat.1006011.
Nkhoma, W.A, Nwanyanwu, O.C, Ziba, C.C., et al. (1999). Cerebral malaria in Malawian children hospitalizedwith Plasmodium falciparum infection. Annals of Tropical Medicine and Parasitology, 93:231–7.16
.
Nwanyanwu, O.C, 1997. Malaria and Human Immunodeficiency Virus Infectionamong Male Employees of Sugar Estate in Malawi: Transactions of Royal Society of Tropical Medicine and Hygiene. 91(5):567-569.
Malaria control state fact sheet (2016)Malaria Consortium, Development House,5664LeonardStreet,London,UnitedKingdom.info@malariaconsortium.og / www.malariaconsortium.org
Obionu C.N, 2007. Primary Health Care for Developing Countries.Enugu, Ezu Books Ltd; 231-233.
Okokon Ita Ita, Kenneth Ogar Inaku, Anthony Achizie Iwuafor, Ubong Anifiok Udoh. (2019). The Pattern of Severe Malaria in Plateau State of Nigeria: A Five- Year Review of Severe Malaria Case-Based Surveillance Data from 2013 to 2017. Central African Journal of Public Health. 5(1):2-57. doi: 10.11648/j.cajph.20190501.18
Oyedeji O.A, Oluwayemi I.O, Afolabi A.A, Bolaji O, Fadero F.F, 2010 Severe Malaria at aTertiary Paediatric Emergency Unit in South West Nigeria, Research J Med Sci; 4(6):352-356.
Olarenwaju, W.I. and Johnson A.W.J. (2001) Malaria in children in Ilorin, Nigeria, East African Medical Journal, 78(3):131-4.
Orimadegun AE, Fawole O, Okereke JO, Akinbami FO, Sodeinde O, Increasing burden of childhood severe malaria in a Nigerian tertiary hospital: implication for control. J Trop Ped 2007; 53:185-189.
Okafor F.U, Oko- Ose J.N, 2012.Prevalence of malaria infections among children aged six months to eleven years (6 months-11 years) in a tertiary institution in Benin City, Nigeria, Glo Adv Res J Med Med Sci; 1(10):273-279.
Ramyil, Alice & Wade, Patricia & Ogoshi, Chris & Goyol, Musa & Adenuga, Olukorede & Dami, Nantok & Mpyet, Caleb. (2015). Prevalence of Trachoma in Jigawa State, Northwestern Nigeria. Ophthalmic epidemiology. 22. 184-9. 10.3109/09286586.2015.1037399.
Trampuz A, Jereb M, Muzlovic I, Prabhu R(2003)."Clinicalreview: Severe malaria." CritCare7 (4): 315-23.
Von Seidlein L, Olaosebikan, R., Hendriksen, I.C, Lee., S.J, Adedoyin, O.T, Agbenyega, T, et al. (2012)Predicting the clinical outcomeof severe falciparum malaria in African children: Findings from a large randomized trial. Clinical Infectious Diseases , 54:1080‑90.
White,N.J.,(2010). Malaria. In: CC, Gordon IA, editor. Manson’sTropical Diseases. 22nd ed.Philadelphia, PA: WB Saunders;p. 1209–81.
White NJ, Pukrittayakamee S, Hien TT, Faiz MA, Mokuolu OA,Dondorp AM,et al. (2014).Malaria. Lancet;383:723‑35.
WHO. (2000). Malaria diagnosis, New Perspectives. Geneva, WorldHealth Organization.WHO/CDS/RBM/2000.14, WHO/MAL/2000.1091
WHO (2018). World Malaria Report. World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland.
WHO (2017). World Malaria Report. World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland.
Woolhouse M.E. (2000). Patterns in parasite epidemiology: the peak shift. Parasitol Today, 14: 428–434.
Yaguo-Ide Lucy Eberechukwu1, Awopeju Abimbola Temitayo Oluwajenyo.A Review of the Pattern of Malaria in Children above Neonatal Age at the University of Port Harcourt Teaching Hospital (2006-2011). Universal Journal of Clinical Medicine 6(1): 10-14, 2018 http://www.hrpub.org DOI:10.13189/ujcm.2018.060102
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