PHYSICOCHEMICAL AND ANTIMICROBIAL PROPERTIES OF TRANSLUCENT SOAP PREPARED USING ALOE VERA GEL AND ZIZIPHUS JUJUBE LEAF EXTRACT AS ANTIMICROBIAL SOURCE
DOI:
https://doi.org/10.33003/fjs-2020-0404-492Keywords:
Soap, translucent, Antimicrobial, Aloe vera, Zizipus jujube, susceptibility testAbstract
In this study, the antimicrobial and physicochemical properties of translucent antimicrobial soap prepared using two medicinal plants, Aloe vera gel and Ziziphus jujube leaf extract was evaluated. The results of the physicochemical analysis showed the pH (7.52±0.02), hardness(1.3 cm±0.02), solubility (0.82 g±0.02) and foamability (6.80 cm±0.03) of the prepared soap and these values were within the acceptable limit set by WHO/SON which make the prepared soap skin-friendly. Similarly, the antimicrobial screening was carried out on selected Gram-positive and gram-negative bacteria as well as on fungi species using disc diffusion methods and the results showed varying antimicrobial activity at different concentrations ranging from 62.5-500 mg/ml. However, the susceptibility of test bacteria in terms of the zone of inhibition at 500mg/ml of the soap was observed on Staphylococcus lentus (22 mm), Staphylococcus aureus (20mm), Escherichia coli (15 mm), Raoltella ornithinolytica (12mm). The result of antifungal properties was as follows, Candida albicans (12 mm), Trichophyton rubrum (12 mm), and Aspergillus nigar (10 mm) at 500 mg/ml concentration. The results when compared to other antimicrobial soap in the market indicate good quality by inhibiting the growth of both Gram-positive, gram-negative bacteria and fungi. The antimicrobial activities exhibited by the soap in this study could be attributed to the presence of phytochemical constituents in the plant extracts, which signify the potential of the soap as an antimicrobial agent. Therefore, these findings confirmed the efficacy of Aloe vera gel and Zizipus jujube extract in traditional medicine.
References
Ajibola, O., Omisakin, O. A., Eze, A. A., and Omoleke, S. A. (2018). Self-medication with antibiotics, attitude and knowledge of antibiotic resistance among community residents and undergraduate students in Northwest Nigeria. Diseases, 6(2): 32-45.
Asim, M., Atta Ur R., Muhammad, Z., Javed, I., and Syed Saeed U. & Hassan. (2016). Self -medication, an emerging Trend. British Journal of Pharmaceutical Research, 14(1), 1-8.
Ateshim, Y., Bereket, B., Major, F., Emun, Y., Woldai, B., Pasha, I. and Russom, M. (2019). Prevalence of self-medication with antibiotics and associated factors in the community of Asmara, Eritrea: a descriptive cross sectional survey. BMC public health, 19(1): 726.
Bennadi, D. (2014). Self-medication: A current challenge. Journal of Basic Clinical Pharmacy, 5(1): 19-23.
Chipwaza, B., Mugasa, J. P., Mayumana, I., Amuri, M., Makungu, C., and Gwakisa, P. S. (2014). Self-medication with anti-malarials is a common practice in rural communities of Kilosa district in Tanzania despite the reported decline of malaria. Malaria Journal, 13(1): 252.
Gebretekle, B. G and Serbessa, K. M. (2016). Exploration of over the counter sales of antibiotics in community pharmacies of Addis Ababa, Ethiopia: pharmacy
Grigoryan, L., Haaijer-Ruskamp, F. M., Burgerhof, J. G. M., Mechtler, R., Deschepper, R., Tambic-Andrasevic, A., Andrajati, R., Monnet, D. L., Cunney, R., and Di Matteo, A., (2006). Self-medication with antimicrobial drugs in Europe. Emerging Infectious Disease, 12(3): 452–459.
Hughes, C. M., McElnay, J. C., and Fleming, G. F. (2001). Benefits and risks of self-medication. Drug Safety, 24:1027–1037.
Jamhour, A., El-Kheir, A., Salameh, P., Hanna, P. A., and Mansour, H. (2017). Antibiotic knowledge and uself-medication practices in a developing country: A cross-sectional study.American journal of infection control, 45(4): 384-388.
Jernberg, C., Lofmark, S., Edlund, C. and Jansson, J. K. (2010). Long-term ecological impacts of antibiotic administration on the human intestinal microbiota. International Society of Microbiology Ecology Journal, 156(11): 3216–3223
Kahnamouei-aghdam, F., Zakeri, A., Amani, F., Sajjadifar, M., Mohammadi, P. and Ojaghi, H. (2017). Self-medication prevalence and related factors among medical university students. International Journal of Basic Clinical Pharmacology, 6(2): 373-376.
Keeney, K. M., Yurist-Doutsch, S., Arrieta, M. C., and Finlay, B. B. (2014). Effects of antibiotics on human microbiota and subsequent disease. Annual review of microbiology, 68: 217-235.
Lei, X., Jiang, H.I., Liu, C., Ferrier, A. and Mugavin, J. (2018). Self-Medication Practice and Associated Factors among Residents in Wuhan, China. International Journal of Environmental Resources Public Health, 15(68): 1-10
Matsuura, H. (2017). Pseudomembranous colitis. An International Journal of Medicine, 761-762
McCullough, A. R., Parekh, S., Rathbone, J., Del Mar, C. B and Hoffmann, T.C. (2016). A systematic review of the public's knowledge and beliefs about antibiotic resistance. Journal of Antimicrobial Chemotherapy, 71(1): 27-33.
Mehmood, A., Rehman, A. U., Zaman, M., Iqbal, J., and Hassan, S. S. U. (2016). Self-medication; An Emerging Trend. Journal of Pharmaceutical Research International, 14(1): 1-8.
Mehta, R. K. and Sharma, S. (2015). Knowledge, attitude and perception of self-medication among medical students. IOSR Journal of Nursing Health Sciences, 4: 89–96.
Mehta, R. K., and Sharma, S. (2015). Knowledge, attitude and practice of self-medication among medical students. Age (years), 20(49): 65-73.
Montastruc, J. L., Bagheri, H., Geraud, T., and Lapeyre-Mestre, M. (1997). Pharmacovigilance of self-medication. Therapie, 52(2): 105-110.
Montastruc, J., Bagheri, H., Geraud, T., and Lapeyre-Mestre, M. (1996). Pharmacovigilance of self-medication. Therapie, 52(2): 105-110.
Naveed, S., Qamar, F., Maqsood, A., Ayub, A., Kauser, H., Malik, H. and Hameed, A. (2015). Prevalence and consequences of misuse of antibiotics, survey based study in Karachi. Journal of Bioequivalence & Bioavailability, 7(5): 202-204.
Nepal, G. and Bhatta, S. (2018) Self-medication with Antibiotics in WHO Southeast Asian Region: A Systematic Review. Cureus, 10(4): 24- 28.
Ngu, R. C., Feteh, V. F., Kika, B. T., Ayeah, C. M., Chifor, T., Njim, T., and Yengo, F. K. F. (2018). Prevalence and determinants of antibiotic self-medication among adult patients with respiratory tract infections in the Mboppi Baptist hospital, Douala, Cameroon: A Cross-Sectional Study.Diseases, 6(2): 49-57.
O'Hara, A. M., and Shanahan, F. (2006). The gut flora as a forgotten organ. EMBO reports, 7(7): 688-693. professionals’ perspective. Antimicrobial Resistance and Infection Control, 5(2): 1-7.
Salgado, P. D. O., Silva, L. C. R. D., Silva, P. M. A., and Chianca, T. C. M. (2016). Physical methods for the treatment of fever in critically ill patients: a randomized controlled trial. Revista da Escola de Enfermagem da USP, 50(5): 823-830.
Seam, R. O. M., Bhatta, R., Saha, L.B., Das, A., DHossain, M. M., Uddin, N. M. S., Karmakar, P., Choudhuri, K. S. M. and Sattar, M. M. (2018). Assessing the Perceptions and Practice of Self-Medication among Bangladeshi Undergraduate Pharmacy Students. Pharmacy, 6(6): 1-12
Shrivastava, S. R., Shrivastava, P. S., and Ramasamy, J. (2014). Public Health Measures to Combat the Menace of Drug Abuse. Primary Health Care, 4, e110.
Sommer, F and Backhed, F. (2013). The gut microbiota—masters of host development and physiology. Nature Reviews Microbiology, 11(4): 227–38.
Souza, L. A., da Silva, C. D., Ferraz, G. C., Sousa, F. A. and Pereira, L. V. (2011). The prevalence and characterization of self-medication for obtaining pain relief among undergraduate nursing students. Revista Latino Americana de Enfermagem, 19: 245–251.
Sunny, T. P., Jacob, R., Krishnakumar, K., and Varghese, S. (2019). Self-medication: Is a serious challenge to control antibiotic resistance? Natural Journal of Physiology Pharmaceutical Pharmacology, 9(9): 821-827.
Ventola, C. L. (2015). The antibiotic resistance crisis: part 1: causes and threats. Pharmacy and therapeutics, 40(4): 277.
Wada, H. Y. (2019), The Menace of Antibiotics Abuse in Nigeria. https://www.pharmanewsonline.com/the-menace-of-antibiotics-abuse-in-nigeria/, Accessed on 1st April, 2020
Yonatan, A., Batseba, B., Feruz, M., Youe, E., Biruck W., Ismail P., Eyasu H. &Mulugeta R. (2019). Prevalence of self-medication with antibiotics and associated factors in the community of Asmara, Eritrea: a descriptive cross sectional survey, BMC Public Health, 19, (726): 1-7.
Yoon, Y. M. and Yoon, S. S. (2018). Disruption of the Gut Ecosystem by Antibiotics. Yonsei Medical Journal, 59(1): 4-12
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