EFFICACY OF SYNTHESIZED SILVER NANO-PARTICLES USING Picralima nitida CRUDE SEED EXTRACT (ABEERE) ON Plasmodium berghei INFECTED MICE
DOI:
https://doi.org/10.33003/fjs-2025-0912-4421Keywords:
Extract, Malaria treatment, medicinal plants, Mice, Plasmodium berghei, parasiteAbstract
Background of the Study: Malaria is a potentially fatal disease caused by Plasmodium parasites. The synthesis of silver nano-particles using plant extracts is getting more attention, due to their application in biomedical sciences such as anti-parasitic, anti-malarial, bactericidal and fungicidal activity.
Aim: This study was designed to evaluate the efficacy of synthesized silver nano-particles using crude seed extract of Picralima nitida on Plasmodium berghei infected mice focusing on weight, percentage parasitemia, packed cell volume (PCV) and white blood cell (WBC) count
Methodology: Thirty mice were randomly divided into six groups of five animals each. Infection was established using Plasmodium berghei, and treatment was administered following a 4-day curative protocol. The infected groups received 25 mg/kg and 50 mg/kg of P. nitida-synthesized silver nanoparticles, while comparison groups received 100 mg/kg and 200 mg/kg of P. nitida crude extract. Changes in weight, parasitemia, PCV, and WBC count were determined using standard hematological and microscopic techniques.
Result: Mice treated with 50mg/kg of Picralima nitida synthesized silver nano-particles showed significant improvement in weight, increased packed cell volume, decreased percentage parasitemia and white blood cell count at the post infection period.
Conclusion: The findings demonstrated that Picralima nitida synthesized silver nano-particles is more effective as an antimalarial agent and preserves red blood cell integrity than Picralima nitida crude extract and hence can be used as an antimalarial drug.
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Copyright (c) 2025 Ahmmed Bayo Opalekunde, Nuhu Abdulrazaq Abdulrazaq, Nassar Sulaiman Adebayo, Aminat Ahmed, Aishat Bolanle Ahmed, Halimat Opeyemi Akanbi, Abdulmumeen Bolakale Shuaib, Mashood Bolaji, Sanda Idiat Modupe
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