EFFECT OF VITAMIN C, E AND SELENIUM ON HAEMATOLOGICAL AND SERUM BIOCHEMISTRY OF ADULT MALE GUINEA PIGS

Abstract

The study was conducted to assess the biopotency of antioxidant supplements on physiological, testicular, and oxidative biomarkers in adult male guinea pigs (Cavia porcellus). A total of 60 adult male guinea pigs of three months of age with an average body weight of 500±20g were randomly allocated into three dietary treatment groups of vitamin C, E and Selenium and each comprised four varying levels with five animals per group in a completely randomized design (CRD). Feed and water was provided ad-libitum. Haematological concentration of guinea pigs in this study indicated a significant (P<0.05) variations in Packed cell volume, Haemoglobin, White blood cell and differential counts of guinea pigs supplemented with varying levels of vitamin C, E and Selenium. The result also indicate a non-significant (P>0.05) difference on Plasma Albumin, Globulin, Total protein, Alanine aminotranferase and Alkaline phosphate of animal supplemented with varying dosage of vitamin E and Selenium. However, a significant (P<0.05) difference occur in Plasma ascorbic acid, Plasma vitamin E, Plasma selenium and Testesterone in guinea pig supplemented with vitamin C, E and Selenium with only exception on Plasma ascorbic acid and Plasma selenium in guinea pigs supplemented with vitamin E and C for Plasma ascorbic acid and Plasma selenium respectively. It could be concluded that vitamin C, E and Selenium can be incorporated into guinea pigs without deleterious effect in both heamatological and serum biochemical profile.  Farmers are therefore recommended to use upto 300mg/kg vitamin C, 45mg/Kg vitamin E and 0.3mg/kg selenium in guinea pigs diet for outstanding...