THERAPEUTIC EFFICACY OF ALLIUM SATIVUM AGAINST SLEEP DEPRIVATION-INDUCED DYSLIPIDEMIA IN ADULT FEMALE WISTAR RATS

Authors

  • Ibrahim Samaila Malgwi
    Department of Human Physiology, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno Nigeria
  • Abdulmalik Muhammad
    Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria. Kaduna State, Nigeria
  • Nachamada Solomon Emmanuel
    Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria. Kaduna State, Nigeria
  • Anas Husainy Yusuf
    Department of Human Physiology, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno Nigeria
  • Godwin H. Yakubu
    Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria. Kaduna State, Nigeria

Keywords:

Allium Sativum, Atherosclerosis, Lipid profile, Sleep deprivation

Abstract

Sleep deprivation (SD) resulting from unhealthy lifestyle choices poses oxidative challenges and is strongly linked to an increased risk and prevalence of various metabolic disorders. While the negative effects of SD on mental health are well documented, its impact on lipid metabolism remains less explored. Allium sativum (Garlic) has been recognized for its cardioprotective properties in different preclinical models. This study aimed to investigate the cumulative effects of acute SD on lipid metabolism and assess the potential therapeutic benefits of aqueous A. sativum extract using female Wistar rats as the experimental model. The animals (N = 25) were categorized into five groups of five animals each (n = 5): Group I served as the normal control and was administered distilled water (1ml/kg), whereas Group II represented the negative control (sleep-deprived, untreated). Groups III, IV, and V received oral administration of A. sativum extract at doses of 100, 200, and 400 mg/kg, respectively, over three weeks. The study analyzed plasma lipid profiles following treatment and found significant reductions in total cholesterol (T. CHOL), triglycerides (TG), and low-density lipoprotein (LDL) across most treated groups. In contrast, high-density lipoprotein (HDL) levels increased, particularly in treated groups compared to Group II. The decrease in TG and LDL was statistically significant (P 0.05), while HDL showed a notable rise. These results suggest that Allium sativum extract may help regulate lipid metabolism and offer protective benefits against cardiovascular diseases and atherosclerosis. However, the limitation of the study is that the acute SD model may...

Dimensions

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Published

14-07-2025

How to Cite

THERAPEUTIC EFFICACY OF ALLIUM SATIVUM AGAINST SLEEP DEPRIVATION-INDUCED DYSLIPIDEMIA IN ADULT FEMALE WISTAR RATS. (2025). FUDMA JOURNAL OF SCIENCES, 9(7), 56-63. https://doi.org/10.33003/fjs-2025-0907-3594

Issue

Vol. 9 No. 7 (2025): FUDMA Journal of Sciences - Vol. 9 No. 7

Section

Research Articles
Copyright & Licensing

FUDMA Journal of Sciences

How to Cite

THERAPEUTIC EFFICACY OF ALLIUM SATIVUM AGAINST SLEEP DEPRIVATION-INDUCED DYSLIPIDEMIA IN ADULT FEMALE WISTAR RATS. (2025). FUDMA JOURNAL OF SCIENCES, 9(7), 56-63. https://doi.org/10.33003/fjs-2025-0907-3594

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