AN ASSESSMENT OF THE ROLE OF ABO BLOOD GROUP ON MALARIA INFECTION IN A HETEROGENOUS COMMUNITY, KADUNA – NIGERIA

ABO blood group and malaria

  • Abdulmalik Abdullahi Salman Department of Biochemistry, Ahmadu Bello University
  • Halima Sadiya Ibrahim Department of Biochmemistry, Ahmadu Bello University, Zaria
  • Aliyu Dantani Abdullahi Department of Biochemistry, Ahmadu Bello University, Zaria
  • Aliyu Mohammed Usman Department of Biochemistry, Ahmadu Bello University, Zaria,
  • Mohammed Nasir Shuaibu Department of Biochmemistry, Ahmadu Bello University, Zaria
Keywords: Malaria, ABO Blood group, Parasitaemia, Parameters

Abstract

Malaria is a global public health concern considered a leading cause of morbidity. A cross-sectional study was carried out to assess the role of ABO blood group on malaria between April and June 2024. A total of 120 blood samples were collected from patients aged five and above, except pregnant women undergoing malaria test at Primal Diagnostic Service in Kaduna state. Blood samples were collected from patients and stained with Field stain using standard parasitological techniques. Agglutination techniques using monoclonal anti-sera A, B and D were used to determine the ABO blood groups and a full blood count analysis was carried out to check some hematological parameters. Data generated was analysed using ANOVA test and statistical significance level was set at P<0.05. An overall malaria prevalence observed showed 53.3% and 30% of the study population had low and moderate malaria parasite densities respectively. About 42.5% and 40% of the population were females and males respectively with malaria parasites. The population of blood group O (43%) patients was higher compared to A (25%), B (18%) and AB (14%) groups respectively. Similarly, group O had the most number of confirmed malaria parasitaemia of 41.4% followed by groups A, B and AB with 26.3%, 16.2% and 16.2% respectively. There was a significant decrease P<0.05 in red blood cell count of malaria-infected patients which was pronounced in blood group O compared to the other blood groups. Data from this study does not show variation in RBC counts in ABO blood group during malaria.

Author Biography

Abdulmalik Abdullahi Salman, Department of Biochemistry, Ahmadu Bello University

Department of Biochemistry,

References

Afoakwah, R., Aubyn, E., Prah, J., Nwaefuna, E. K., & Boampong, J. N. (2016). Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana. 2016. DOI: https://doi.org/10.1155/2016/5368793

Bartoloni, A., & Zammarchi, L. (2012). Clinical aspects of uncomplicated and severe malaria. In Mediterranean Journal of Hematology and Infectious Diseases (Vol. 4, Issue 1). https://doi.org/10.4084/MJHID.2012.026 DOI: https://doi.org/10.4084/mjhid.2012.026

Cihan, Y. B., Baykan, H., Kavuncuoglu, E., Mutlu, H., Kucukoglu, M. B., Ozyurt, K., & Oguz, A. (2013). Relationships between skin cancers and blood groups - link between non-melanomas and ABO/Rh factors. Asian Pacific Journal of Cancer Prevention, 14(7), 41994203. https://doi.org/10.7314/APJCP.2013.14.7.4199 DOI: https://doi.org/10.7314/APJCP.2013.14.7.4199

De Mattos, L. C. (2011). Molecular polymorphisms of human blood groups: A universe to unravel. Revista Brasileira de Hematologia e Hemoterapia, 33(1), 67. https://doi.org/10.5581/1516-8484.20110005 DOI: https://doi.org/10.5581/1516-8484.20110005

Gupte, S. C., Patel, A. G., & Patel, T. G. (2012). Association of ABO groups in malaria infection of variable severity. In J Vector Borne Dis (Vol. 49). http://journals.lww.com/jvbd DOI: https://doi.org/10.4103/0972-9062.213383

Jenkins, R., Omollo, R., Ongecha, M., Sifuna, P., Othieno, C., Ongeri, L., Kingora, J., & Ogutu, B. (2015). Prevalence of malaria parasites in adults and its determinants in malaria endemic area of Kisumu County, Kenya. Malaria Journal, 14(1). https://doi.org/10.1186/s12936-015-0781-5 DOI: https://doi.org/10.1186/s12936-015-0781-5

Mosha, J. F., Sturrock, H. J. W., Brown, J. M., Hashim, R., Kibiki, G., Chandramohan, D., & Gosling, R. D. (2014). The independent effect of living in malaria hotspots on future malaria infection: an observational study from Misungwi , Tanzania. 18. DOI: https://doi.org/10.1186/1475-2875-13-445

Oloko, M., & Ekpo, R. (2018). Exploring traditional weaning practices in North Western Nigeria; Food, knowledge and culture: A step towards safeguarding community food security. Academic Journal of Interdisciplinary Studies, 7(2), 97106. https://doi.org/10.2478/ajis-2018-0050 DOI: https://doi.org/10.2478/ajis-2018-0050

Osisiogu, E. U., Agyapong, G. A. A., Mahmoud, F. C., Waqas, F. Bin, Appiah, C., & Nikoi, C. N. (2023). Prevalence of Malaria among ABO Blood Groups in Ghana: A Case Study of Adentan Municipality. International Journal of Pathogen Research, 12(1), 2129. https://doi.org/10.9734/ijpr/2023/v12i1217 DOI: https://doi.org/10.9734/ijpr/2023/v12i1217

Oue, L., Coluzzi, M., & Walliker, D. (2004). GENETIC COMPLEXITY OF PLASMODIUM FALCIPARUM IN TWO ETHNIC GROUPS OF BURKINA FASO WITH MARKED DIFFERENCES IN SUSCEPTIBILITY TO MALARIA. 71(2), 173178. DOI: https://doi.org/10.4269/ajtmh.2004.71.173

Panda, A. K., Panda, S. K., Sahu, A. N., Tripathy, R., Ravindran, B., & Das, B. K. (2011). Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis. 3, 18. DOI: https://doi.org/10.1186/1475-2875-10-309

Pathirana, S. L., Alles, H. K., Bandara, S., Phone-Kyaw, M., Perera, M. K., Wickremasinghe, A. R., Mendis, K. N., & Handunnetti, S. M. (2005). ABO-blood-group types and protection against severe, Plasmodium falciparum malaria. Annals of Tropical Medicine and Parasitology, 99(2), 119124. https://doi.org/10.1179/136485905X19946 DOI: https://doi.org/10.1179/136485905X19946

Shan, F., Ullah, K., Khan, A., Rahat, A., Ali, S., & Khan, M. K. (2024). A Comprehensive Study on Prevalence, Species Distribution, and Influencing Factors of Malaria in Dir Lower, Pakistan. Journal of Health and Rehabilitation Research, 4(1), 12561260. https://doi.org/10.61919/jhrr.v4i1.554 DOI: https://doi.org/10.61919/jhrr.v4i1.554

Snow, R. W. (2015). Global malaria eradication and the importance of Plasmodium falciparum epidemiology in Africa. 1416. https://doi.org/10.1186/s12916-014-0254-7 DOI: https://doi.org/10.1186/s12916-014-0254-7

Tazebew, B. (2021). Prevalence and association of malaria with ABO blood group and hemoglobin levels in individuals visiting Mekaneeyesus Primary Hospital , Estie District , northwest Ethiopia: A cross-sectional study. 124. DOI: https://doi.org/10.21203/rs.3.rs-19054/v1

Tekeste, Z., & Petros, B. (2010). The ABO blood group and Plasmodium falciparum malaria in Awash , Metehara and Ziway areas , Ethiopia. 25. DOI: https://doi.org/10.1186/1475-2875-9-280

Tela, I. A., Modibbo, M. H., Adamu, L. H., & Taura, M. G. (2015). RA Journal of Applied Research Prevalence Of Malaria Infection Among ABO Blood Groups In Jamaare, Nigeria. 1. https://doi.org/10.18535/rajar/v1i7.04

Theron, M., Cross, N., Cawkill, P., Bustamante, L. Y., & Rayner, J. C. (2018). An in vitro erythrocyte preference assay reveals that Plasmodium falciparum parasites prefer Type O over Type A erythrocytes. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-26559-2 DOI: https://doi.org/10.1038/s41598-018-26559-2

Varo, R., Chaccour, C., & Bassat, Q. (2020). Update on malaria. Medicina Clnica (English Edition), 155(9), 395402. https://doi.org/10.1016/j.medcle.2020.05.024 DOI: https://doi.org/10.1016/j.medcle.2020.05.024

White, N. J. (2022). Severe malaria. In Malaria Journal (Vol. 21, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s12936-022-04301-8 DOI: https://doi.org/10.1186/s12936-022-04301-8

WHO. (2024). World Malaria Report 2024. World Health Organization.

Wolofsky, K. T., Ayi, K., Branch, D. R., Hult, A. K., Olsson, M. L., Liles, W. C., Cserti-Gazdewich, C. M., & Kain, K. C. (2012). ABO Blood Groups Influence Macrophage-mediated Phagocytosis of Plasmodium falciparum-infected Erythrocytes. PLoS Pathogens, 8(10). https://doi.org/10.1371/journal.ppat.1002942 DOI: https://doi.org/10.1371/journal.ppat.1002942

Yeda, R., Okudo, C., Owiti, E., Biwot, G., Momanyi, C., Korir, W., Mitsanze, T., Tegerei, C., Juma, D., Opot, B., Mwakio, E., Chemwor, G., Okoth, R., Ochora, D. O., Cheruiyot, A. C., Roth, A., Akala, H. M., & Andagalu, B. (2022). Burden of malaria infection among individuals of varied blood groups in Kenya. Malaria Journal, 17. https://doi.org/10.1186/s12936-022-04251-1 DOI: https://doi.org/10.1186/s12936-022-04251-1

Published
2025-06-30
How to Cite
Salman, A. A., Ibrahim, H. S., Abdullahi, A. D., Usman, A. M., & Shuaibu, M. N. (2025). AN ASSESSMENT OF THE ROLE OF ABO BLOOD GROUP ON MALARIA INFECTION IN A HETEROGENOUS COMMUNITY, KADUNA – NIGERIA: ABO blood group and malaria. FUDMA JOURNAL OF SCIENCES, 9(6), 52 - 56. https://doi.org/10.33003/fjs-2025-0906-3500