AMELIORATIVE POTENTIALS OF Trigonella foenum-graecum (FENUGREEK) SEEDS ON PROTEIN-ENERGY MALNOURISHED RATS
Abstract
Malnutrition especially Protein-Energy Malnutrition (PEM) is one of the major challenges that brings about both short and long term health issues as well as weaken immune system and necrosis. It accounts for 45% of child deaths in both low and middle income countries. Trigonella foenum-graecum, a leguminous plant known for its antiviral, antimicrobial, anti-inflammatory and antioxidant was evaluated for its potential as diet supplement in the body of a protein-energy malnourished individual using wistar rats as a model. 74 female wistar rats weighing between 50 and 70g used for the study were malnourished by feeding them with low protein iso-caloric diet for 4 weeks. The rat samples were grouped namely as untreated group (malnourished rats that were not treated), commercial-fed group (malnourished rats treated with commercial feed), 25 g/kg, 50 g/kg and 100 g/kg supplemented diets groups (malnourished rats treated with 25 g/kg, 50 g/kg and 100 g/kg fenugreek seeds supplemented diets respectively) and were treated for 4 weeks after which they were sacrificed. The proximate analysis of the feeds were carried out, the anthropometric parameters, hematological parameters, total protein and lipid profile of the experimental animals were also assessed. There were significant (p0.05) difference in the observed parameters of malnourished rats when compared with the control which were reversed when treated with fenugreek seed supplemented diets. Hence, 25 g/kg, 50 g/kg and 100 g/kg fenugreek seed supplemented diets improves the nutritional status of malnourished rats.
References
AbdelAzeem F 2006 Effect of using fenugreek and fennel seeds as natural feed additives on performance of broiler chicks Saudi Journal of Nutrition and Feeds 92 116 httpswwwresearchgatenetpublication343721562
Albers JJ Warnick GR and Chenng MC 1978 Quantitation of High Density Lipoproteins Lipids 1312 926932 DOI: https://doi.org/10.1007/BF02533852
AOAC 2009 Official Methods of Analysis 17th Edition The Association of Official Analytical Chemists Methods 92510 65 17 9742499216
Dacie JV and Lewis SM 1991 Practical Hematology 7th Edition 5479
Doshi M Mirza A Umarji B and Karambelker RR 2012 Effects of Trigonella foenum graecum FenugreekMehti on Hemoglobin Levels in Females of Child Bearing Age Biomedcal ResearchIndia 231 4750
Duru M Erdoan Z Duru A Kkgl A Dzgner V Kaya DA and ahin A 2013 Effect of Seed Powder of a Herbal Legume Fenugreek Trigonella foenumgraceum L on Growth Performance Body Components Digestive Parts and Blood Parameters of Broiler Chicks Pak J Zool 45 10071014
Fedacko J Singh R B Niaz M A Ghosh S Fedackova P Tripathi A D Etharat A Onsaard E Singh V K and Shastun S 2016 Fenugreek seeds decrease blood cholesterol and blood glucose as adjunct to diet therapy in patients with hypercholesterolemia World Heart Journal 83 239249
Fredrickson DS Levy RI and Lees RS 1967 Fat transport in lipoproteins An integrated approach to mechanisms and disorders New Engl J Med 276 148156 DOI: https://doi.org/10.1056/NEJM196701262760406
Gornall AG Bardawill CJ and David MM 1949 Determination of serum proteins by means of the biuret reaction Journal of Biological Chemistry 1772751766 DOI: https://doi.org/10.1016/S0021-9258(18)57021-6
Hainline AJR Cooper GR and Olansky AS 1980 CDC Survey of high density lipoprotein cholesterol measurement A report Atlanta Lipid Standardization Program Center for Disease Control 3
Jiang W Zhao Y Wu X Du Y and Zhou W Health inequalities of globalproteinenergy malnutrition from 19902019 and forecast prevalence for 2044 datafrom the global burden of disease study 2019 Public Health 225 102109 DOI: https://doi.org/10.1016/j.puhe.2023.10.003
Khan TM Wu DB and Dolzhenko AV 2018 Effectiveness of fenugreek as a galactogogue A network metaanalysis Phytother Res 323 402412
Konopelnyuk V kot L Makai S and Ostapchenko L 2015 Effect of Trigonella foenumgraecum seed powder on athropometric and nutritional parameters Journal of Applied Pharmaceutical Science 511 95100 DOI: https://doi.org/10.7324/JAPS.2015.501116
Kumar V Akhouri V Singh KS and Kumar A 2021 Therapeutic effect of fenugreek Trigonella foenumgraecum seeds extract against arsenic induced toxicity in Charles Foster rats Journal of Applied and Natural Science 133 1083 1093 DOI: https://doi.org/10.31018/jans.v13i3.2899
Lambe MO and Bewaji CO 2021 Moringa Oleifera leafbased diet combats malnutrition in rats Biokemistri 332 8996 httpwwwbiolineorgbrbk
Mehram EB Salem AM Alanaany A and Alfauomy GA 2022 The protective effect ofwater extracts of Fenugreek chicory and olives on some biochemical parameters European journal of Nutritional health 17 1 3554 DOI: https://doi.org/10.21608/ejnh.2022.259244
Morteza M Dousti M Sayehmiri F and Pourmahmoudi AA 2019 An Investigation of the Prevalence and Causes of Malnutrition in Iran a Review Article and Metaanalysis Clinical Nutritional Research 82 101118 httpsdoiorg107762cnr201982101
Nadia B Claude R Joseph J H and Brigitte R A 1999 Low Protein Isocaloric Diet During Gestation Affects Brain Development And Alter Permanently Cerebral Cortex Blood Vessels In Rat Offspring The American Society for Nutritional Sciences The Journal of Nutrition
Paneru D TellezIsaias G Romano H Lohokare G Bottje WG and Lohokare J 2022 Effects of graded levels of fenugreek Trigonella foenumgraecum L seeds on the growth performance hematological parameters and intestinal histomorphology of broiler chickens Veterinary Science 95 207 httpsdoiorg103390vetsci9050207 DOI: https://doi.org/10.3390/vetsci9050207
Raju J Patlolla J Swamy MV and Rao CV 2004 Diosgenin a steroid saponins of Trigonella foenum graecum Fenugreek inhibits azoxymethaneinduced aberrant crypt foci formation in F344 rats and induces apoptosis in HT29 human colon cancer cells Cancer Epidemiol Biomarkers Prev 13813921398 httpsdoiorg101158105599651392138 DOI: https://doi.org/10.1158/1055-9965.1392.13.8
Scoccia EA Molinuevo MS McCarthy AD and Cartizo A 2001 A simple method to assess the oxidative susceptibility of low density lipoproteins BMC Clinical Pathology 11 1 httpwwwbiomedcentralcom1472689011 DOI: https://doi.org/10.1186/1472-6890-1-1
Singh A Rai J Mahajan D S 2016 Comparative evaluation of glipizide and fenugreek Trigonella foenumgraecum seeds as monotherapy and combination therapy on glycaemic control and lipid profile in patients with type 2 diabetes mellitus International Journal of Basic Clinical Pharmacology 5 942950 DOI: https://doi.org/10.18203/2319-2003.ijbcp20161549
Singh A Singh S and Sharma R 2020 Nutritional potentials of Nutrient profile of Fenugreek Trigonella foenumgraecum L International Journal of current Microbiology and Applied Sciences 910 36063615
Singh N Yadav SS Kumar S and Narashiman B 2022 Ethnopharmacological phytochemical and clinical studies on fenugreek Trigonella foenumgraecum L Food Science 46 131 DOI: https://doi.org/10.1016/j.fbio.2022.101546
Singh S Chaurasia PK and Bharati SL 2023 Hypoglycemic and hypocholesterolemic properties of Fenugreek A comprehensive assessment Journal of Applied Food Research 32 117 DOI: https://doi.org/10.1016/j.afres.2023.100311
Tim N 2020 What is nutrition and why does it matter Rv Natalie Butler Medical News Today httpswwwmedicalnewstdaycomarticles160774
Veniamin MP VakirtziLemonias C 1970 Chemical basis of the
Wani SA and Kumar P 2018 Fenugreek A review on its nutraceutical properties and utilization in various food products J Saudi Soc Agric Sci 17 97106 World Health Organization 2022 Fact sheet Malnutrition DOI: https://doi.org/10.1016/j.jssas.2016.01.007
Yakubu M T Oladiji A T and Akanji M A 2009 Mode of cellular toxicity of aqueous extract of Fadogia agrestis Schweinf Ex Hiern stem in male rat liver and kidney Human and Experimental Toxicology 288 469478 DOI: https://doi.org/10.1016/j.jep.2007.10.004
Yousefi E Zareiy S Zavoshy R Noroozi M Jahanihashemi H and Ardalani H 2017 Fenugreek A therapeutic complement for patients with borderline hyperlipidemia A randomised doubleblind placebocontrolled clinical trial Advances in Integrative Medicine 4 3135 DOI: https://doi.org/10.1016/j.aimed.2016.12.002
Zenhom M and Ibrahim IH 2020 Effects of fenugreek seed byproduced meal on growth performance feed utilization body composition and some physiological traits for common carp Cryprius Carpio European Journal of Anesthesiology 103 8195 DOI: https://doi.org/10.21608/eja.2020.44476.1037
Zhang X Zhang L Pu Y Sun M Zhao Y Zhang D Wang X Li Y Guo D and He S 2022 Global Regional and National Burden of ProteinEnergy Malnutrition A systematic Analysis for the Global Burden of Disease Study Nutrients 14 13 2592 httpsdoiorg103390nu14132592 DOI: https://doi.org/10.3390/nu14132592
Copyright (c) 2024 FUDMA JOURNAL OF SCIENCES
This work is licensed under a Creative Commons Attribution 4.0 International License.
FUDMA Journal of Sciences
