THERAPEUTIC POTENTIAL OF ETHANOL EXTRACT OF ACACIA NILOTICA (L.) DELILE AND ANOGEISSUS LEIOCARPUS (DC.) GUILL. & PERR IN DIABETIC WOUND HEALING: EVIDENCE FROM MALE WISTER RAT
DOI:
https://doi.org/10.33003/fjs-2024-0805-2690Keywords:
Acacia nilotica, Anogeissus leiocarpus, Anti-diabetic, Diabetic rat, Streptozotocin, Wound healingAbstract
The use of plants in traditional medicinal systems has been practiced for thousands of years and continues to supply people with new remedies. The current study evaluated the wound healing effect of ethanol extracts of Acacia nilotica pod and Anogeissus leiocarpus stem bark on rat models. Fourty two (42) Streptozotocin (60 mg/kg) induced diabetic male Wistar rats were divided into seven (7) groups of six (6) rats each. A one-centimeter-diameter excision wound was created on the mid-dorsal area of the experimental diabetic rats. The treatment groups were treated daily with the plant extracts by oral administration at doses of 200 mg/kg and 400 mg/kg for 14 days. Blood glucose level, percentage of wound contraction of the experimental rat groups were observed for 21 days. Histopathological examination was also carried out at the end of the experiment. The findings indicated that both A. leiocarpus at doses of 200 mg/kg, 400 mg/kg and A. nilotica at 200 mg/kg enhanced wound contraction in the diabetic rats at day 14 compared to the standard drug (Metformin) which occurred at day 21. This showed a significant reduction in blood glucose level of the treated diabetic rats as well as wound healing effect by the tested plants extract.
References
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Hussaini, Y., Yakubu, R.B., & Mustapha, T. (2022). Preliminary phytochemical screening and GC-MS analysis of Anogeissus leiocarpus stem bark extract. The Pharma Innovation Journal, 11(11), 113-117.
Jame, R. (2018). Phytochemical and Pharmacological Uses of Acacia nilotica- A Review. International Journal of Bioorganic Chemistry, 3(2), 6-10. https://doi.org/10.11648/j.ijbc.20180302.11
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Negbenebor, H.E., Shehu, K., Mukhtar, M.F., Oiza, A.Z., Nura, S., & Fagwalawa, L.D., (2017). Ethno botanical survey of medicinal plants used by Hausa people in the management of diabetes mellitus in Kano metropolis, northern Nigeria. European Journal of Medicinal Plants, 18(2), 1-10. https://doi.org/10.9734/EJMP/2017/28562
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Oguntibeju, O. O. (2019). Medicinal plants and their effects on diabetic wound healing. Veterinary world, 12(5), 653–663. https://doi.org/10.14202/vetworld.2019.653-663
Saeed, K.B., Mohammed, H.A., Al Gahdali, E., Omer, S.K., & Ahmad, A. (2018). Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin Induced Diabetes in Sprague-Dawley Rats. Journal of Diabetes Research. 1-10. https://doi.org/10.1155/2018/4692197 1-10
Saini, P., & Verma, P.K. (2019). Evaluation of the wound healing properties of mimosa pudica linn. In streptozotocin-induced diabetes mellitus in rats. International journal of pharmaceutical Sciences and Research, 10(2), 661-665. http://dx.doi.org/10.13040/JPSR.0975-8232
Salihu, T.S., Bello, L., Wara S.H., & Ali S. (2015). An ethno botanical survey of anti diabetic plants used by Hausa-Fulani tribes in Sokoto, northest Nigeria. Journal of ethnopharmacology, 172, 91-99.
Sani S.B., Usman, B.M., Hayatu, M., Mardiyya, A.Y., Bilkisu A., Umma, A., Namadina, M.M., Hassan, M.I., Safiyanu, I., Jibril, A., Ajingi, Y.S. & Sale, A.I. (2021). In vitro evaluation of Anisopus mannii and Leptadenia hastate for antibacterial potential against bacterial isolates from diabetic wound. FUDMA Journal of Sciences, 5(2),109-113.
Sani, H.D., & Aliyu, B.S. (2011). A survey of major ethno medicinal plants of Kano North, Nigeria, their knowledge and uses by traditional healers. Bayero Journal of Pure and Applied Sciences, 4(2), 28-35. https://doi.org/10.4314/bajopas.v4i2.6
Sani, S.B., & Aliyu, B. (2022). Determination of antibacterial activity of five medicinal plants traditionally used for the treatment of diabetic foot infection in Kano state, Nigeria. Bayero Journal of Pure and Applied Sciences, 13(1), 305 – 312. https://doi.org//10.4314/bajopas.v13i1.47S
Sani, S.B., Aliyu, B.S., Haruna, M., Yahya, S.M., Mardiyya, A.Y., Ajingi, Y.S., Wada, L.H., & Abba, H. (2019). Local plants and diabetes management: folkloric practices in metropolitan Kano, Nigeria. Bayero Journal of Pure and Applied Sciences, 12(1), 268-273. https://doi.org/10.4314/bajopas.v12i1.41S
Sani, S.B., Surayya, L.I., Binta, M.S., Namadina, M.M., Aisha, M.G., Mardiyya, A.Y., Aisha, T., Mujittafa, L., Ladan, W.H., Hamisu, A., Taufiq, K.M., Hadiza, R.I. & Hassan, M.I. (2024). Phytochemical analysis and antioxidant potential of ethnol extracts of Anogeissus leiocarpus (DC.) Guill & Perr and Acacia nilotica (L.) Delile. Biological Sciences, 04(01), 525-534.
Santosh, K.R., Rajkiran, K., & Kumar, S.P. (2017). Evaluation of Incisional Diabetic Wound Healing Activity of Ethanolic Leave Extract of Mimosa pudica L. in Rats. International Journal of Pharmacognosy and Phytochemical Research, 9(8), 1143-1147. https://doi.org/10.25258/PHYTO.V9I08.9623
Sene, M., Diop, N., Oury, M.M., Sarr., A., Sylva, F.A., Ndiaye, M., Ndiaye-Sy, A., & Yoro, G.S. (2023). Healing, Anti-inflammatory and Anelgesic activities of the methanolic extract of Acacia nilotica pods (Mimosaceae). International journal of pharmacology, 19(1), 40-51. https://doi.org/10.3932/ijp.2023.40.51
Victor, Y.A.B., Boye, A., & Ayaba, S. (2013). Phytochemical Screening and assessment of wound healing activity of the leaves of Anogeissus leiocarpus. European Journal of Experimental Biology, 3(4), 18-25.
Zheng, T., Shu, G., Yang, Z., Mo, S., Zhao, Y., & Mei, Z. (2012). Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats. Journal of ethnopharmacology, 139(3), 814–821. https://doi.org/10.1016/j.jep.2011.12.025
Aiyeloja, A.A., & Bello, O.A. (2006). Ethno botanical potentials of common herbs in Nigeria: A case study of Enugu state. Academic Journal of Educational Research Review, 1(1), 16-22.
Alhassan, D.A., Ibrahim, A.U., Umar, A.M., & Ya’u, Y.M. (2016). Phytochemical Screening and Antimicrobial Activity of Crude Stem Bark Extracts of Anogeissus leiocarpus. European Journal of Medicinal Plants, 11(2), 1-7. https://doi.org/10.9734/EJMP/2016/22443
Ali, M., Diso, S.U., Minjibir, A.A., Sani, J.A., Nas, F.S., & Yahya, A. (2017). Assessment of medicinal plants used in treatment of various ailments in Kano city Nigeria. Asian Journal of Biotecnology and Bioresource Technology, 2(4), 1-11. https://doi.org/10.9734/ajb2t/2017/38844
Buhari, S.S., Aliyu, B.S., Hayatu, M., Aliyu, M., Nazifi, A.B., & Nuhu, Y. (2021). Ethno medicinal practices in the treatment of diabetic foot ulcers in Kano State, northwestern Nigeria. Journal of Medicinal Herbs, 12(2), 67-84. https://doi.org/10.30495/medherb.2021.684581
Eltayeb, I.M., Ali, H.A., Muddather, A., & Ayoub, S.M.H. (2016). Antioxidant Activity and Cytotoxic Studies of Anogeissus leiocarpous Root, Leaf and Stem. American Journal of Research Communication, 4(3), 52-67.
Fakim A. (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine, 27, 1-93
Frode, T.S., & Medeiros, Y.S. (2008). Animal models to test drugs with potential antidiabetic activity. Journal of Ethnopharmacology, 5(2), 173-183. https://doi.org/10.1016/j.jep.2007.10.038
Hussaini, Y., Yakubu, R.B., & Mustapha, T. (2022). Preliminary phytochemical screening and GC-MS analysis of Anogeissus leiocarpus stem bark extract. The Pharma Innovation Journal, 11(11), 113-117.
Jame, R. (2018). Phytochemical and Pharmacological Uses of Acacia nilotica- A Review. International Journal of Bioorganic Chemistry, 3(2), 6-10. https://doi.org/10.11648/j.ijbc.20180302.11
Kankara, S.S., Sani, D., Mustafa, M., Ibrahim, M.H., & Go, R. (2017). .Acacia nilotica pods’ water extract enhances wound healing in Sprague-Dawley rats by alleviating oxidative stress and suppressing proinflammatory cytokines. Nigerian Journal of Scientific Research, 16(2), 202-210.
Lawal, I.O., Uzokwe, N.E., Igboanugo, A. B.I., Adio A.F., & Faloye B. (2010). Ethnomedicicinal information on collation and identification of some medicinal plants in research institute of south-west Nigeria. African journal of pharmacy and pharmacology, 4(1), 1-7.
Negbenebor, H.E., Shehu, K., Mukhtar, M.F., Oiza, A.Z., Nura, S., & Fagwalawa, L.D., (2017). Ethno botanical survey of medicinal plants used by Hausa people in the management of diabetes mellitus in Kano metropolis, northern Nigeria. European Journal of Medicinal Plants, 18(2), 1-10. https://doi.org/10.9734/EJMP/2017/28562
Njogu, M. S., Arika, M.W., Machocho, K. A., Ngeranwa, J.N. J., & Njagi, N.M. E (2017). In vivo antidiabetic activity of aqueous and ethyl acetate leaf extract of Senna singuena (Delile) in alloxan induced diabetic mice. The Journal of Phytopharmacology, 6(2), 84-92. https://doi.org/10.31254/phyto.2017.6204
Nurdiana, S., Goh, Y.M., & Ahmad, H. (2017). Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. BMC Complement Altern Medicine, 17(290). https://doi.org/10.1186/s12906-017-1762
Odoh, U.E., & Ezugwu, C.O. (2012). Anti-diabetic and toxicological studies of the alkaloids of Acanthus montanus (Acanthaceae) Leaf. Planta Medica, 36. http://dx.doi.org/10.1055/s-0032-1320305
Oguntibeju, O. O. (2019). Medicinal plants and their effects on diabetic wound healing. Veterinary world, 12(5), 653–663. https://doi.org/10.14202/vetworld.2019.653-663
Saeed, K.B., Mohammed, H.A., Al Gahdali, E., Omer, S.K., & Ahmad, A. (2018). Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin Induced Diabetes in Sprague-Dawley Rats. Journal of Diabetes Research. 1-10. https://doi.org/10.1155/2018/4692197 1-10
Saini, P., & Verma, P.K. (2019). Evaluation of the wound healing properties of mimosa pudica linn. In streptozotocin-induced diabetes mellitus in rats. International journal of pharmaceutical Sciences and Research, 10(2), 661-665. http://dx.doi.org/10.13040/JPSR.0975-8232
Salihu, T.S., Bello, L., Wara S.H., & Ali S. (2015). An ethno botanical survey of anti diabetic plants used by Hausa-Fulani tribes in Sokoto, northest Nigeria. Journal of ethnopharmacology, 172, 91-99.
Sani S.B., Usman, B.M., Hayatu, M., Mardiyya, A.Y., Bilkisu A., Umma, A., Namadina, M.M., Hassan, M.I., Safiyanu, I., Jibril, A., Ajingi, Y.S. & Sale, A.I. (2021). In vitro evaluation of Anisopus mannii and Leptadenia hastate for antibacterial potential against bacterial isolates from diabetic wound. FUDMA Journal of Sciences, 5(2),109-113.
Sani, H.D., & Aliyu, B.S. (2011). A survey of major ethno medicinal plants of Kano North, Nigeria, their knowledge and uses by traditional healers. Bayero Journal of Pure and Applied Sciences, 4(2), 28-35. https://doi.org/10.4314/bajopas.v4i2.6
Sani, S.B., & Aliyu, B. (2022). Determination of antibacterial activity of five medicinal plants traditionally used for the treatment of diabetic foot infection in Kano state, Nigeria. Bayero Journal of Pure and Applied Sciences, 13(1), 305 – 312. https://doi.org//10.4314/bajopas.v13i1.47S
Sani, S.B., Aliyu, B.S., Haruna, M., Yahya, S.M., Mardiyya, A.Y., Ajingi, Y.S., Wada, L.H., & Abba, H. (2019). Local plants and diabetes management: folkloric practices in metropolitan Kano, Nigeria. Bayero Journal of Pure and Applied Sciences, 12(1), 268-273. https://doi.org/10.4314/bajopas.v12i1.41S
Sani, S.B., Surayya, L.I., Binta, M.S., Namadina, M.M., Aisha, M.G., Mardiyya, A.Y., Aisha, T., Mujittafa, L., Ladan, W.H., Hamisu, A., Taufiq, K.M., Hadiza, R.I. & Hassan, M.I. (2024). Phytochemical analysis and antioxidant potential of ethnol extracts of Anogeissus leiocarpus (DC.) Guill & Perr and Acacia nilotica (L.) Delile. Biological Sciences, 04(01), 525-534.
Santosh, K.R., Rajkiran, K., & Kumar, S.P. (2017). Evaluation of Incisional Diabetic Wound Healing Activity of Ethanolic Leave Extract of Mimosa pudica L. in Rats. International Journal of Pharmacognosy and Phytochemical Research, 9(8), 1143-1147. https://doi.org/10.25258/PHYTO.V9I08.9623
Sene, M., Diop, N., Oury, M.M., Sarr., A., Sylva, F.A., Ndiaye, M., Ndiaye-Sy, A., & Yoro, G.S. (2023). Healing, Anti-inflammatory and Anelgesic activities of the methanolic extract of Acacia nilotica pods (Mimosaceae). International journal of pharmacology, 19(1), 40-51. https://doi.org/10.3932/ijp.2023.40.51
Victor, Y.A.B., Boye, A., & Ayaba, S. (2013). Phytochemical Screening and assessment of wound healing activity of the leaves of Anogeissus leiocarpus. European Journal of Experimental Biology, 3(4), 18-25.
Zheng, T., Shu, G., Yang, Z., Mo, S., Zhao, Y., & Mei, Z. (2012). Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats. Journal of ethnopharmacology, 139(3), 814–821. https://doi.org/10.1016/j.jep.2011.12.025
Published
2024-09-18
How to Cite
Buhari, S. S., & Aliyu, B. S. (2024). THERAPEUTIC POTENTIAL OF ETHANOL EXTRACT OF ACACIA NILOTICA (L.) DELILE AND ANOGEISSUS LEIOCARPUS (DC.) GUILL. & PERR IN DIABETIC WOUND HEALING: EVIDENCE FROM MALE WISTER RAT. FUDMA JOURNAL OF SCIENCES, 8(5), 117 - 123. https://doi.org/10.33003/fjs-2024-0805-2690
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Section
Research Articles
FUDMA Journal of Sciences
