PREVALENCE OF MALARIA, THE EFFECT OF PARASITAEMIA ON BLOOD PARAMETERS AND IRON LEVEL OF INFECTED CHILDREN UNDER FIVE YEARS OF AGE IN ITU, SOUTH-SOUTH, NIGERIA
Abstract
Malaria is a devastating public health concern in Itu with varied haematological and biochemical implications. This study seeks to crystalize the prevalence of malaria, the effect of parasitaemia on some haematological parameters, and serum iron level of infected children under 5 in Itu Local Government Area, Nigeria. The study adopted a cross-sectional study involving 430 children. Blood samples were obtained from consented caregivers. Malaria prevalence and parasitaemia level were diagnosed microscopically. Haematology auto-analyzer was used to determine haematological parameters. Malaria prevalence of 41.08% was recorded in the study. The highest prevalence (42.86%) was reported among the female subjects. The difference in the infection rate between males and females was statistically significant (p<0.05). The infected children tended to have significantly lower mean haemoglobin, packed cell volume, red blood cell level, lymphocyte, monocytes, and eosinophil count, (p < 0.005) and a higher mean neutrophil, as well as white blood cell count (p < 0.05) compared to the non-infected subjects respectively. A weak correlation between the level of parasitaemia and Hb (r= 0.108), PCV(r=0.247), RBC (r= o.074), and a weak negative with WBC (r = -0.063) was also reported. The study also recorded a higher mean serum ferritin level (648 ng/ml) compared to non-infected, lower mean serum transferrin (6.41 ng/ml) compared to normal, and mean serum iron (54.40 ng/ml) was higher than normal. It is essential to pay keen attention to the evaluation of haematological and biochemical parameters in the management of malaria infection in children living in malaria-endemic areas.
References
Abdalla, S. H. (2008). Hematopoiesis in Human Malaria. Blood Cells, 16:401–416. PMID: 2257320.
Abro, A. H., Ustadi, A. M., Younis, N. J., Abdou, A. S., Hamed, D. A., Saleh, A. A. (2008) Malaria and Hematological Changes. Pakistan Journal of Medical Science, 24(2):287–291. www.pjms.com.pk
Adelekan, D. A. and Thurnham, D. I. (1990) Plasma Ferritin Concentrations in Anaemic Children and Relative Importance of Malaria, Riboflavin Deficiency, and other Infections. American Journal of Clinical science and Nutrition, 51: 453-456. https://doi.org/10.1093/ajcn/51.3.453 DOI: https://doi.org/10.1093/ajcn/51.3.453
Akwa Ibom State Ministry of Health (2000). Resume of activities: malaria and vector control. Area Operatonal Plan Report. 16. https://thinkwell.global/wp-content/uploads/2021/06/Malaria-Annual-Operational-Plan-Development-Final.pdf
Akwa Ibom State Ministry of Health (2022). Malaria elimination programme: Prospect and challenges. Special Committee Report. 64. https://thinkwell.global/wp-content/uploads/2021/06/Malaria-Annual-Operational-Plan-Development-Final.pdf
Ahlan, M. A., Jacobs, A. and Oluboyede, O. A. (2001). Determination of Serum Iron, Total Iron-Binding Capacity and Serum Ferritin in Healthy Saudi Adults. Annals of Saudi Medicine, 21(1-2): 100-103. https://doi.org/10.1186/s12936-023-04710-3 DOI: https://doi.org/10.5144/0256-4947.2001.100
Antwi Bafour, S, Mensah, BT, Johnson, G, Armah, DNO, Ali Mustapha, S, and Annison L, Haematological parameters and their correlation with the degree of malaria parasitaemia among outpatients attending a polyclinic. Malaria Journal, 2023; 22:281. https://doi.org/10.1186/s12936-023-04710-3 DOI: https://doi.org/10.1186/s12936-023-04710-3
Anumudu, C. I., Adepoju, A., Adeniran, M., Adeoye, O., Kassim, T. (2006). Malaria Prevalence and Treatment Seeking Behavior of Young Nigerian Adults. Annals of African Medicine, 15: 82-88. http://www.academicjournals.org/JCMR
Aribodor, U. D. N., Njoku, O. O., Eneanya, C. I. and Onyali. I. O. (2003). Studies on Prevalence of Malaria and Management Practices of the Azia Community, Ihiala LGA, Anambra State, Southeast Nigeria. Nigerian Journal of Parasitology, 24:33-38. https://doi.org/10.4314/njpar.v24i1.37802 DOI: https://doi.org/10.4314/njpar.v24i1.37802
Atting, I. A., Ukoh, V. J., Usip, L. P. and Ebere, N. (2016). Prevalence of Intestinal and Malaria Parasitic Infections among School Age Children in a Rural Community (Nkwot Nko) in Akwa Ibom State, Nigeria. American journal of research communication. 1-14. www.usa-journals.com
Bassey, B. E. (2017). Prevalence of malaria and the vectorial capacity of mosquitoes in Itu Local Government Area, Akwa Ibom State. M.Sc Desertation, Post Graduate School, University of Uyo, Uyo. 43. http://www.uniuyo.edu.ng .
Beesley, R., Filteau, S. and Tomkins, A. (2000). Impact of Acute Malaria on Plasma Concentrations of Transferrin Receptors. Transaction of Research in Sociology of Tropical Medicine and Hygiene, 94:295-298. https://doi.org/10.1016/s0035-9203(00)90329-8 . DOI: https://doi.org/10.1016/S0035-9203(00)90329-8
Brabin, B. J. (2012). The role of malaria in nutritional anemia. In: Fomon SJ, Slotkins S (eds). Nutritional Anemia. New York. Raven press. 65-80. https://doi.org/10.53730/ijhs.v6nS2.8427 DOI: https://doi.org/10.53730/ijhs.v6nS2.8427
Brooker, S., Akhwale, W. S., Pullan, R. (2007). Epidemiology of Plasmodium-helminth Co-infection in Africa: Potential Impact on Anaemia, Prospects for Combining Control. American Journal of Tropical Medicine and Hygiene, 77 (6):88-98. PMCID: PMC2637949. DOI: https://doi.org/10.4269/ajtmh.2007.77.88
Centre for Disease Control and Prevention. (CDC) (2004). Laboratory procedure manual: complete blood count with 5-part deferential. Atlanta: Centers for Disease Control and Prevention. https://wwwn.cdc.gov/nchs/data
Cheesbrough, M. (2005). District laboratory practices in tropical countries. Part I 2nd ed. Cambridge University Press, 239-258. https://www.medbox.org/preview/5255d6e DOI: https://doi.org/10.1017/CBO9780511581304
Christine, A. N. (2013). The Interpretation of Indicators of Iron Status during an Acute phase Response. Annex 4, 97-108. https://doi.org/10.1258/acb.2007.007167 DOI: https://doi.org/10.1258/acb.2007.007167
Eledo, B. O. and Izah, S. C. (2018). Studies on Some Haematological Parameters among Malaria Infected Patients Attending a Tertiary Hospital in Nigeria. Open Access Blood Research Transaction Journal, 2(3): 555586. http://dx.doi.org/10.19080/OABTJ.2018.02.555586
Eledo, B. O. and Izah S. C. (2018). Studies on Some haematological parameters among malaria infected patients attending a tertiary hospital in Nigeria. Blood Research and Transfusion Journal, 2(3):1-5. http://dx.doi.org/10.19080/OABTJ.2018.02.555586
Erhart, L. M., Yingyuen, K., Chuanak, N., Buathong, N., Laoboonchai, A., Miller, R. S., Meshnick, S. R., Gasser, R. A. Jr, Wongsrichanalai, C. (2014). Hematologic and clinical indices of malaria in a semi-immune population of western Thailand. Amercan Journal of Tropical Medicine and Hygiene 2014, 70:8–14. PMID: 14971691. DOI: https://doi.org/10.4269/ajtmh.2004.70.8
Francis, U., Isaac, Z., Yakubu, A., Enosakhare, A., Felix, E. (2014). Haematological parameters of malaria infected patients in the University of Calabar Teaching Hospital, Calabar, Nigeria. Journal of Hematology Thromboembolic Diseases, 2: 171. https://doi.org/10.4172/2329-8790.1000171 DOI: https://doi.org/10.4172/2329-8790.1000171
Gansane, A., Ouedraogo, I. N. Henry, N. B. Soulama, I. Ouedraogo, E. Yaro, J., Diarra, A., Benjamin1, S., Konate, A. T., Tiono, Alfred., Sirima, S. B. (2013). Variation in haematological parameters in children less than five years of age with asymptomatic Plasmodium infection: implication for malaria field studies. Memorial Instistute Oswaldo Cruz, Rio de Janeiro, 108(5): 644-650. https://doi.org/10.1590%2F0074-0276108052013017 DOI: https://doi.org/10.1590/0074-0276108052013017
Hajison PL, Mwakikunga BW, Mathanga DP, Feresu SA. Seasonal variation of malaria cases in children aged less than 5 years old following weather change in Zomba district, Malawi. Malaria Journal 2017; 16(1):264. https://doi.org/10.1186/s12936-017-1913-x
Igbeneghu, C., Odaibo, A. B. and Olaleye, D. O. (2011). Impact of asymptomatic malaria on some hematological parameters in the Iwo community in Southwestern Nigeria. Medical principles and practices 20: 459-463. https://doi.org/10.1159/000327673 DOI: https://doi.org/10.1159/000327673
Izah, S. C., Bassey, S. E., Ohimain, E. I. (2017). Assessment of pollution load indices of heavy metals in cassava mill effluents contaminated soil: a case study of small-scale cassava processing mills in a rural community of the Niger Delta region of Nigeria. Bioscience Methods, 8(1): 1-17. 21. http://dx.doi.org/10.5376/bm.2017.08.0001 DOI: https://doi.org/10.5376/bm.2017.08.0001
Kitua, A. Y., Rutstein, S., Johnson, K., Pande, R. P. and Wagstaff, A. (1997). Socioeconomic Differences on Health, Nutrition, and Population. In: HNP/Poverty Thematic Group. Washington DC: World Bank. PMID: 18293634
Kotepui, M., Phunphuech, B., Phiwklam, N., Chupeerach, C. and Duangmano, S. (2014). Effect of malarial infection on haematological parameters in population near Thailand-Myanmar border. Malaria Journal, 13:218. https://doi.org/10.1186/1475-2875-13-218 DOI: https://doi.org/10.1186/1475-2875-13-218
Klinkenberg, E., McCall, P. J., Hastings, I. M., Wilson, M. D. and Amerasinghe, F. P. (2005). Malaria and irrigated crops, Accra, Ghana. Emerging Infectious Diseases, 11: 1290-1293. https://doi.org/10.3201%2Feid1108.041095 DOI: https://doi.org/10.3201/eid1108.041095
Maina, R. N., Walsh, D., Gaddy, C., Hongo, G., Waitumbi, J., Otieno, L., Jones, D. and Ogutu, B. R. (2010). Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malaria Journal 9(3): 4. https://doi.org/10.1186/1475-2875-9-S3-S4 . DOI: https://doi.org/10.1186/1475-2875-9-S3-S4
Marielle, K. B. A., Denisa, E. I. C., Modeste, M. M., Eric, K. Pierre, B. M., Elie, M. and Maryvome, K. (2003). Prevalence of Plasmodium falciparum infection in pregnant women in Gabon. Malaria Journal, 2: 2-18. https://doi.org/10.1186/1475-2875-2-18 DOI: https://doi.org/10.1186/1475-2875-2-18
Mawson, A. R. (2013). The pathogenesis of malaria: a new perspective. Pathogical Global Health. 107:122–129. https://www.who.int/news-room DOI: https://doi.org/10.1179/2047773213Y.0000000084
Menendez, C., Fleming, A. F. and Alonso, P. L. (2000). Malaria-related anaemia. Parasitology Today, 16: 469–476.. https://doi.org/10.1016/s0169-4758(00)01774-9 DOI: https://doi.org/10.1016/S0169-4758(00)01774-9
Mockenhaupt, F.P., Rong, B., Gunther, M., Beck, S. and Till, H. (2000). Anaemia in pregnant Ghanaian women: Importance of malaria, iron deficiency and haemoglobinopathies. Transactions of the Royal Society of Tropical Medicine and Hygiene, 94: 477-483 https://doi.org/10.1016/s0035-9203(00)90057-9 DOI: https://doi.org/10.1016/S0035-9203(00)90057-9
Mockenhaupt, F. P., May, J., Stark, K., Falusi, A. G., Meyer, C. G. and Bienzle, U. (1999). Serum transfer in receptor levels are increased in asymptomatic and mild Plasmodium falciparum infection. Haematologica, 84: 869-873. PMID: 10509032
Nigeria Malaria Indicator Survey (NMIS) (2022). 2021 Nigeria South South Zone Malaria Indicator Survey. Fact sheet. https://dhsprogram.com/pubs/pdf/MIS41/MIS41.pdf
Obeagu, E. I., Didia, B. C., Obeagu, G. U., Azuonwu, O. (2017). Evaluation of Changes in Haematological Profile of Cerebral Malaria Patients in Enugu State, Southeast, Nigeria. Annal of Clinical Laboratory Research, 5(4): 202.16. www.imedpub.com
Odunukwe, N. N., Salako, L. A., Okanny, C., Ahmed, O. A., Mafe, A. G., Efinemokwu, C. and Raheem, T. Y. (2001). Serum ferritin and other haematological measurements in apparently healthy children with malaria parasitaemia in Lagos, Nigeria. West African Journal of Medicine, 20: 42-45. PMID: 11505886
Okoroiwu IL, Obeagu EI, Elemchukwu Q, Ochei KC. Some Hematological Parameters In Malaria Parasitaemia. IOSR Journal of Dental and Medical Sciences 2014;13(9):74-77. http://www.iosrjournals.org/iosr-jdms/papers/Vol13-issue9/Version-3/P013937477.pdf
Olasehinde, G. I., Ajayi, A. A., Taiwo, S. O., Adekeye, B. T. and Adeyeba, O. A. (2010). Prevalence and management of falciparium malaria among infants and children in Ota, Ogun State, Southwestern Nigeria. African Journal of Clinical Experiment in Microbiology, 11: 159-163. https://doi.org/10.4314/ajcem.v11i3.57773 DOI: https://doi.org/10.4314/ajcem.v11i3.57773
Olivier, M., Van Den Ham, K., Shio, M. T., Kassa, F. A., Fougeray, S. (2014). Malarial pigment hemozoin and the innate infammatory response. Front Immunology, 5:25. https://doi.org/10.3389/fimmu.2014.00025 DOI: https://doi.org/10.3389/fimmu.2014.00025
Onyido, A. E., Obinatu, S. C., Umeanaeto, P. U., Obiukwu, M. O. Egbuche, M. C. (2011). Malaria prevalence and mosquito vector abundance in Uli Town, Ihiala Local Government Area, Anambra State, Nigeria. African Journal of Biomedical Research, 14: 175 – 182. 13. www.ajbrui.net. DOI: https://doi.org/10.4314/afrrev.v5i3.67332
Precious, L. H., Bonex, W. M., Don. P. M. and Shingairai, A. F. (2017). Seasonal variation of malaria cases in children aged less than 5 years old following weather change in Zomba district, Malawi. Malaria Journal, 16: 264. https://doi.org/10.1186/s12936-017-1913-x DOI: https://doi.org/10.1186/s12936-017-1913-x
President’s Malaria Initiative (PMI) (2015). Nigeria malaria operational plan FY 2015. President’s Malaria Initiative. 13. https://reliefweb.int/report/nigeria/president-s-malaria-initiative-nigeria-
Price, R. N., Simpson, J. A., Nosten, F., Luxemburger, C., Hkirjaroen, L., ter Kuile, F. Chong suphajaisiddhi, T. and White, N. J. (2001). Factors contributing to anemia after uncomplicated falciparum malaria. American Journal of Tropical Medicine and Hygiene, 65:614–622. https://doi.org/10.4269/ajtmh.2001.65.614 DOI: https://doi.org/10.4269/ajtmh.2001.65.614
Sam, W., Amusa, S. O., Idowu, A. A. and Mafiana, O. A. (2010). Assessment of HIV and Malaria infections and perception among antenatal women in Ogun state, Nigeria. Journal of National Science and Engineering Technology, 9: 115 – 123. https://api.semanticscholar.org/CorpusID:73383181
Sam, W., Amusa, S. O., Igbeneghu, C., Odaibo, A. B. and Mafiana, O. A. (2014). Assessment of HIV and Malaria infections and perception among antenatal women in Ogun state, Nigeria. Journal of National Science and Engineering Technology, 9: 88 – 111. https://api.semanticscholar.org/CorpusID:73383181
Senthilkumaar, P. and Sarojini, S. (2013). Haematological studies in malaria affected patients in North Chennai, Tamil Nadu. European Journal of Experimental Biology, 3: 199-205. www.pelagiaresearchlibrary.com
Statistical Year Book of Akwa Ibom State of Nigeria (2013). Directorate of Statistics of Statistics of Statistics Ministry of Economic Development Ministry of Economic Development Uyo. 2013 Edition. https://nigerianstat.gov.ng/elibrary/read/232
Stoltzfus, R., Dreyfuss, M. Barba, C. and Kotecha, P. (2000). Guidelines for the use of iron supplements to prevent and treat iron deficiency anaemia. ILSI Press, Washington, DC.. http://apps.who.int/iris/bitstream/10665/42792/1/9241580348_eng_Volume1.pdf
Sumbele, I. U. N., Theresa, N. A., Samje, M., Ndzeize, T. and Ndzeize, E. M. (2010). Hematological changes and recovery associated with untreated and treated plasmodium faciparum infection in children in the mount Cameroon region. Journal of Clinical Medicine and Resources 2: 143-151. http://www.academicjournals.org/JCMR
Syafruddin, D., Krisin, A., Sekartuti, P. and Dewi, R. M. (2009). Seasonal prevalence of malaria in West Sumba district, Indonesia. Malaria Journal 8: 8. DOI: https://doi.org/10.1186/1475-2875-8-8 . DOI: https://doi.org/10.1186/1475-2875-8-8
Torti, F. M. and Torti, S.V. (2019). Regulation of ferritin genes and protein. Blood, 99: 3505-3516. DOI: https://doi.org/10.1186/1475-2875-8-8 DOI: https://doi.org/10.1182/blood.V99.10.3505
World Health Organization (WHO). World malaria report. Geneva: World Health Organization, 2029. https://www.who.int/news-room
World Health Organization. World Malaria Report 2023. https://www.who.int/teams/global-malaria-programme World Health Organization. (2010). Guideline for the Treatment of Malaria. Second Edition. WHO Geneva. /reports/world-malaria-report- https://www.who.int.
World Health Organisation. (2016). Management of severe malaria: A practical hand book http://www.who.int/malaria/docshbsm.pdf
Williams, T. N., Maitland, K., Rees D. C., Peto, T. E., Bowden, D. K., Weatherall, D. J. and Clegg, J. B. (2011). Reduced soluble transferrin receptor concentrations in acute malaria in Vanuatu. American Journal of Tropical Medicine and Hygiene, 60: 875-878. https://doi.org/10.4269/ajtmh.1999.60.875 DOI: https://doi.org/10.4269/ajtmh.1999.60.875
Yip, R. (2004). Changes in iron metabolism with age. In: Brock, J. H., Halliday, J., Pippard, M. J., Powell, L. W. (eds). Iron Metabolism in health and disease. WB Saunders. London 427-428p. https://doi.org/10.1111/hdi.12542 DOI: https://doi.org/10.1111/hdi.12542
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