IMPACT OF Plasmodium falciparum PARASITAEMIA ON SOME HEMATOLOGICAL PROFILES AMONG CHILDREN 6-59 MONTHS: A CASE STUDY OF SELECTED HOSPITALS IN MAIDUGURI, BORNO STATE, NIGERIA
Plasmodium falciparum is responsible for millions of deaths globally, with children under five (5) years old the most vulnerable. It is associated with some haematological changes. As a result, this study was carried out to evaluate the effects of P. falciparum parasitaemia on certain haematological parameters in Malaria-affected Children in Maiduguri. To ascertain the prevalence and haematological alterations brought on by infection, blood samples were taken from 421 kids during the months of December 2021 and June 2022 (7 months). Overall results show 182 (43.23%) patients were positive to malaria while 239 (56.77%) were negative. Similarly, the PCV, RBC and thrombocytes count respectively (23.95%, 2.94x10-9/µL and 346.23X10-9/µL and 147.15X10-9/µL) of the malaria positives subjects were significantly (p=0.05) lower compared to the malaria negative (34.69%, 4.0 X10-9/µL and 346.23 X10-9/µL) subjects. Furthermore, the mean WBC, lymphocytes and neutrophils respectively of the malaria positive subjects were significantly higher compared (18.67 x10-9/µL, 59.88% and 66,05%) to the infected ones (12.92 x10-9/µl, 37.69% and 47.05%). The result also shows the mean of sex comparison of haematological parameters of children infected with malaria, with the PCV and thrombocytes of male positive subject been significantly lower than that of the female negative children (24.40% and 145.98X10-9/µ) versus (34.82% and 337.00X10-9/µl) appropriately (p=0.05), whereas the mean WBC, lymphocytes and neutrophils were significantly higher compared to female positive subjects (17.48X10_9/µl, 59.46% and 63.95%) versus (18.64 x10-9/µl, 60.48% and 69.04%), (p=0.01, 0.05). In conclusion, malaria is highly prevalent among children, 21-30 months old in Maiduguri and it is associated...
Abdalla, S.H. (1988). Peripheral Blood and Bone Marrow Lencocytes in Gambia Children with Malaria: Numerical Changes and Evaluation of Phagocytosis. Annals of Tropical Pathology, 8:250-258. DOI: https://doi.org/10.1080/02724936.1988.11748582
Abdalla, S.H., & Pasvol, G. (2004) Malaria: A Hematological Perspective Imperial College Press; London, UK DOI: https://doi.org/10.1142/p290
Abro, A.H., Abdalla M.U., Nadeem, J.Y., & Ahmed A.S. (2008).” Malaria &Hematological Changes” Pakistani Journal of Medical Science, 24:287-291.
Adesina, K.T., Balogun, O.R., Babatunde, A.S., Sani, M.A., Fadeye, A., & Aderebigbe, S. (2009). Impact of malaria parasitemia on haematological parameters in pregnant women at booking in Ilorin, Nigeria. Trends in Medical Research, 4:84-90. DOI: https://doi.org/10.3923/tmr.2009.84.90
Allen, S. J, O’Donnell, N. D., Alexander, M. P., Alpers., & Weatherall D. J. (1997). Proceedings of National Academic Sciences of the United State America 94:14736-14741. DOI: https://doi.org/10.1073/pnas.94.26.14736
Bashawri, L. A., Mandil, A. A., Bahnassy, A. A., & Ahmed, M. A. (2002). Malaria: hematological aspects. Annals of Saudi medicine, 22(5-6), 372-376. DOI: https://doi.org/10.5144/0256-4947.2002.372
Boehlen, F. (2006). “Thrombocytopenia During Pregnancy. Importance, Diagnosis and Management” Hanistaseslogic, 26:72-4, 2006. DOI: https://doi.org/10.1055/s-0037-1616880
Borno State Ministry of Information (2015). Federal Republic of Nigeria, National Bureau of Statistics; accessed 28 September, 2015.
Centre for Disease Control and Prevention (2004). Biology of Malaria, accessed online at www.cdc.gov/malaria biology/index.htm.
Chandra, S., & Chandra, H, (2013). Role of hematological parameters as an indicator of acute malarial infection in uttarakhand State of India. Mediterranean Journal of Hematology and infectious Disease, 5(1) e2013009. DOI: https://doi.org/10.4084/mjhid.2013.009
Chiaka, I.A., Christian, I.A., Victor N., Roseangela I.N., & Mark N. (2007). “Epidemiological Factors that Promote the Development of Malaria Anaemia in Children in Ibadan”, African Health Science, 7:(2):80-85,
Chiwakata, C.B., Hammer, C.J., & Dietrich, M. (2000). Hogh level of inducible nitric oxide Synhassmina are associated with increased monocytes counts in blood and have a beneficial role in P. falciparum malaria. Infection immunity, 68:394-0399. DOI: https://doi.org/10.1128/IAI.68.1.394-399.2000
Chotivanich, K., Udomsangpetch, R., Simpson, J. A., Newton, P., Pukrittayakamee, S., Looareesuwan, S., & White N. J. (2000) Parasite Multiplication Potential and the Severity of P. falciparum. Malaria Journal of Infectious Diseases, 181:1206-1209. DOI: https://doi.org/10.1086/315353
Christiana, A.N. (2015). Assessment of the role of malaria in the aetiology of renal impairment in ISU Community in Community in Ebonyi State., Nigeria. University of Nigeria Virtual Library, 1-169
Dole D.C., & Wolf S.M (1973). Studies of the neutropenia of acute malaria, Blood. 197-206 DOI: https://doi.org/10.1182/blood.V220.127.116.11
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