ANTINOCICEPTIVE PROPERTIES OF LEAF AQUEOUS EXTRACT OF CROSSOPTERYX FEBRIFUGA (AFZEL. EX G. DON) BENTH

Authors

  • A. O. Isah
  • M. Idu
  • F. C. Amaechina

DOI:

https://doi.org/10.33003/fjs-2022-0605-1750

Keywords:

Antinocicepyive, Crossopteryx febrifuga, Evaluation, Pain, Writhing

Abstract

Nociceptive pain is a sensational discomfort that is usually associated with injury or illness found affecting the body either internally or externally. Crossopteryx febrifuga is one of the medicinal plants which are locally used in the management of pain especially in the North Central Region of Nigeria. Many conventional drugs which are being applied in managing pain aside being not affordable and readily accessible by the majority of people at rural areas have one side effect or the other. Therefore, this research was conducted to evaluate the potentiality of aqueous extract of C. febrifuga in alleviating pain in Wistar rats. The study was carried out using acetic acid induced writhing and Edson hot plate methods. On acetic acid induced pain, the aqueous extract at 50 and 100 mg/kg inhibited pain significantly by reducing the number of writhing by average of 3.9 per minute while at 200 mg/kg, the extract reduced pain by reducing the number of writhing by average of 4.2 per minute. Similarly, the extract at all doses administered in hot plate induced method inhibited pain by increasing the time the rats took to jump off the hot plate. The data obtained from the analgesic study of C. febrifuga aqueous extract suggests that it has anti-nociceptive property as evident in both models. This, therefore revealed that the plant leaf aqueous extract possessed both the peripherally and centrally mediated analgesic properties. For this reason, the plant leaf could be a potential antinociceptive agent if subjected to clinical trial and proved 

References

Adejoh Isaac, (2016). Analysis of Rainfall Characteristics of Lokoja, Unpublished B.Sc Geography Project Submitted to the Department of Geography, Federal University Lokoja.

Adejuwon, J.O., (2004). Crop yield Response to Climate Variability in the Sudano- Sahelian Ecological Zones of Nigeria in Southwestern Nigeria. In AIACC Report of Workshop for Africa and Indian Ocean Island. Dakar, Senegal, 15-16.

Adeoye, O.. J. (2012). Spatial- Temporal Analysis of Land Use/Cover Change of Lokoja. A Conference Town Journal of Geography and Geology, Vol. 4, p 4.

Adger Conway, (2003). Changing Wind Systems and Climate Change in the Mid-Latitudes. Progress in Development Studies, 3(3): 1719-195.

Audu, E. B. (2001). The Hydrological Consequences of Urbanization in Nigeria: Case Study of Lokoja, Kogi State, Nigeria. Unpublished M.Tech. Thesis Submitted to the Post Graduate School, Federal University of Technology, Minna, Niger State, Nigeria

Audu, E. B. (2012). An Analytical View of Temperature in Lokoja, Kogi State. International Journal of Science and Technology Vol. 2. No. 12.

Audu, E.B., Rizama D.S, Obateru, O.C and Binbol, N.C (2013) An Assessment of Socio-economic Impacts of Rainstorms as a Meteorological Hazard in Lokoja L.G.A of Kogi State, Nigeria. Journal of Science, Technology, Mathematics and Education (JOSTMED) 9(3), 44-51.

Audu, E.B. (2015). A Descriptive Analysis of Rainfall for Agricultural Planning in Lokoja Local Government Arca of Kogi State. International Journal of Science and Technology, Volume 2 No.12.

Bruce Geerts (2009). Lake Effect Snow. University of Wyoming. Retrieved 2008-12-24.

Adejo, C (2007). The Effect of Rainfall and Temperature on Maize Yield in Kogi State. Asian Journal of Basic and Applied Sciences Vol. 1 (No.2): 2313-7797.

Chris C. Mooney (2007). Storm world: hurricanes, politics, and the battle over global warming.

Houghton Mifflin Harcourt. p. 20. ISBN 978-0-15-101287-9. Retrieved 2009-08-31.

Daily Post, 2017

Doswell, D. (1985). Assessing the Vertical Distribution of Convective Available PotentialEnergy. Weather and Forecasting. American Meteorological Society. Vol. 13 No.3

Kogi State Government (2019) Political Structure. Available online at kogistate.gov.ng/political structure.html. Retrieved on 20/8/19.

National Emergency Management Agency (NEMA) (2010). Summary of Relief Interventions. Unpublished Manual, 1 – 23.

Nigerian Meteorological Agency (NiMet) (2016) Climate change 2001: The Scientific Basis. Annual Weather Reportl 139 (4): 489 – 492

National Population Commission (1991). Final Results of Population Census of Nigeria.

National Population Commission (2006). Final Results of Population Census of Nigeria.

Nwachukwu, J.O (2017) Rainstorm Kills Pregnant Woman, Four Others in Lokoja. Daily Post, April 17

Obot N.I and Onyeukwu N.O (2010) Trend of Rainfall in Abeokuta, Ogun State Nigeria; A 2- Year Experience (2006-2007). Journal of Environmental Issues 2(1), 70-81

Ogundele Olayinka, (2007) Changing Patterns of Rainstorms in South West Nigeria.

GeoJournal. 22(1): 99 –107

Ogallo, O (1977) Small Rainfall Events: an Ecological Role in Semi-Arid Regions. Ecology 53:301-304.

Olatunde, A.F.(2013) Analysis of Drought Occurrences in Northern Nigeria: Implications for Agricultural Planning and Development, PhD Dissertation, Department of Geography, Nigerian Defence Academy

Olatunde, A.F. and Adejoh, I. (2017) Intensity, Duration and Frequency of Rainstorms in Lokoja, Science World Journal Vol 12 (No.2).

Olatunde, A.F. and Adejoh, I (2018) Rainfall Characteristics in Lokoja from 1981 to 2015. Journal of Research and Development in Arts and Social Sciences, Vol.2. PP 228-242, Faculty of Arts and Social Sciences, Federal University Lokoja, Nigeria.

Olatunde, A.F. and Ruth, O. (2019) “Assessment of Relationship between the Trends of Temperature and Forest Changes in Lokoja Kogi Sate, Nigeria” A Chapter in a festschrift: Functional Human Settlements In Nigeria: The Urban and Regional Planning Perspectives. Published by the Department of Urban and Regional Planning, Benue State University Markudi. PP 67 - 85

Olayinka, O (2007) Changing Patterns of Rainstorms in South West Nigeria. Geo.Journal 22(1), 99-107

Olivera, F., Mckinney, D. C., Maidment, D. R., Zichuan, Y., & Reeds, S. (1995). Predicting the Water Balance of Surface and Groundwater Resources over Large Areas. Accessed via www.saprofs.tamu.edu/folivera/utexas/ng_stdy.htm/nigstdy.htm. On 26 Dec. 2015.

Gomez, P. (2005). Climate Change in Tropical Brazil:Change in the Thunderstorm Receipt. Weather: 43(6): 242248pp 122-124.

Senesi S, (2002). A climatology of mesoscale convective systems over Europe using satelliteinfrared imagery II: Characteristics of European mesoscale convectivesystems.

Quarterly Journal of the Royal Meteorological Society. 128 (584)

Udofia, E. P. (2015): Applied Statistics with Multivariate Methods. Immaculate Publications Limited. Enugu. ISBN: 978-036-231-2

Weibull, W. (1939) “A Statistical Theory of the Strength of Materials” Generalstabens Litografiska Anstalts, Forlag, Stockholm.

Yakubu, M.A(2018) “LOCAL Winds, Thunderstorms and Perception of Effects on Farming Activities in Lokoja. A Project Submitted to the Department of Geography, Federal University Lokoja.

Published

2022-10-31

How to Cite

Isah, A. O., Idu, M., & Amaechina, F. C. (2022). ANTINOCICEPTIVE PROPERTIES OF LEAF AQUEOUS EXTRACT OF CROSSOPTERYX FEBRIFUGA (AFZEL. EX G. DON) BENTH. FUDMA JOURNAL OF SCIENCES, 6(5), 255 - 258. https://doi.org/10.33003/fjs-2022-0605-1750