ACUTE AND SUB CHRONIC TOXICITY PROFILE OF METHANOL EXTRACT OF TETRACARPIDIUM CONOPHORUM SEEDS ON WISTAR ALBINO RATS

  • Kelly Oriakhi
  • Omorede Ikponmwosa-Eweka
Keywords: Tetracarpidium conophorum, toxicity, extracts, acute, sub chronic

Author Biographies

Kelly Oriakhi

Department of Medical Biochemistry, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Edo State, Nigeria

Omorede Ikponmwosa-Eweka

Department of Medical Biochemistry, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Edo State, Nigeria

References

Abraham, I.G. and Ahmad, M.H. (2021). Preliminary sub-acute toxicological assessment of methanol leaves extract of Culcasia angolensis (Araceae) in Wistar rats. Bulletin of the National Research Centre, 45, pp.1-10. DOI: https://doi.org/10.1186/s42269-021-00686-9

Ajaiyeoba, E.O. and Fadare, D.A. (2006). Antimicrobial potential of extracts and fractions of the African walnut-Tetracarpidium conophorum. Afr J Biotechnol ; 5(22):2322–5.

Akindele, A.J., Adeneye, A.A., Salau, O.S., Sofidiya, M.O. and Benebo, A.S., 2014. Dose and time-dependent sub-chronic toxicity study of hydroethanolic leaf extract of Flabellaria paniculata Cav.(Malpighiaceae) in rodents. Frontiers in pharmacology, 5, p.78.10.3389/fphar.2014.00078 DOI: https://doi.org/10.3389/fphar.2014.00078

Akomolafe, S.F., Oboh, G., Oyeleye, S.I. and Olasehinde, T.A. (2017). Toxicological effects of aqueous extract from African walnut (Tetracarpidium conophorum) leaves in rats. Journal of Evidence-Based Complementary & Alternative Medicine, 22(4), pp.919-925. https://doi.org/10.1177/2156587217718979 DOI: https://doi.org/10.1177/2156587217718979

Aliakbarzadeh, G., Sereshti, H. and Parastar, H. (2016). Pattern recognition analysis of chromatographic fingerprints of Crocus sativus L. secondary metabolites towards source identification and quality control. Analytical and Bioanalytical Chemistry, 408, pp.3295-3307. DOI: 10.1007/s00216-016-9400-8 DOI: https://doi.org/10.1007/s00216-016-9400-8

Atanasov, A.G., Waltenberger, B., Pferschy-Wenzig, E.M., Linder, T., Wawrosch, C., Uhrin, P., Temml, V., Wang, L., Schwaiger, S., Heiss, E.H. and Rollinger, J.M. (2015). Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology advances, 33(8), pp.1582-1614. https://doi.org/10.1016/j.biotechadv.2015.08.001 DOI: https://doi.org/10.1016/j.biotechadv.2015.08.001

Awodele, O., Popoola, T.D., Amadi, K.C., Coker, H.A.B. and Akintonwa, A., (2013). Traditional medicinal plants in Nigeria—Remedies or risks. Journal of ethnopharmacology, 150(2), pp.614-618. https://doi.org/10.1016/j.jep.2013.09.015 DOI: https://doi.org/10.1016/j.jep.2013.09.015

Buenz, E.J., Schnepple, D.J., Bauer, B.A., Elkin, P.L., Riddle, J.M. and Motley, T.J. (2004). Techniques: bioprospecting historical herbal texts by hunting for new leads in old tomes. Trends in pharmacological Sciences, 25(9), pp.494-498. DOI: https://doi.org/10.1016/j.tips.2004.07.003

Ching, C.K., Chen, S.P.L., Lee, H.H.C., Lam, Y.H., Ng, S.W., Chen, M.L., Tang, M.H.Y., Chan, S.S.S., Ng, C.W.Y., Cheung, J.W.L. and Chan, T.Y.C. (2018). Adulteration of proprietary Chinese medicines and health products with undeclared drugs: experience of a tertiary toxicology laboratory in Hong Kong. British journal of clinical pharmacology, 84(1), pp.172-178. DOI: https://doi.org/10.1111/bcp.13420

De Smet, P.A. (2004). Health risks of herbal remedies: an update. Clinical Pharmacology & Therapeutics, 76(1), pp.1-17. DOI: https://doi.org/10.1016/j.clpt.2004.03.005

Edem, C.A., Dosunmu, M.I. and Bassey, F.I. (2009). Determination of proximate composition, ascorbic acid and heavy metal content of African walnut (Tetracarpidium conophorum). Pakistan Journal of Nutrition, 8(3), pp.225-226. DOI: https://doi.org/10.3923/pjn.2009.225.226

Ekor, M. (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in pharmacology, 4, p.177. DOI: https://doi.org/10.3389/fphar.2013.00177

El Kabbaoui, M., Chda, A., El-Akhal, J., Azdad, O., Mejrhit, N., Aarab, L., Bencheikh, R. and Tazi, A. (2017). Acute and sub-chronic toxicity studies of the aqueous extract from leaves of Cistus ladaniferus L. in mice and rats. Journal of ethnopharmacology, 209, pp.147-156. DOI: https://doi.org/10.1016/j.jep.2017.07.029

El-Seedi, H.R., Burman, R., Mansour, A., Turki, Z., Boulos, L., Gullbo, J. and Göransson, U. (2013). The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: discovery of an active cardiac glycoside from Urginea maritima. Journal of Ethnopharmacology, 145(3), pp.746-757. DOI: https://doi.org/10.1016/j.jep.2012.12.007

Esteban, M.Á., Cuesta, A., Chaves-Pozo, E. and Meseguer, J. (2015). Phagocytosis in teleosts. Implications of the new cells involved. Biology, 4(4), pp.907-922. DOI: https://doi.org/10.3390/biology4040907

Fugh-Berman, A., (2000). Herb-drug interactions. The Lancet, 355(9198), pp.134-138. DOI: https://doi.org/10.1016/S0140-6736(99)06457-0

Gowda, S., Desai, P.B., Kulkarni, S.S., Hull, V.V., Math, A.A. and Vernekar, S.N. (2010). Markers of renal function tests. North American journal of medical sciences, 2(4), p.170.

Hosseinzadeh, S., Jafarikukhdan, A., Hosseini, A. and Armand, R. (2015). The application of medicinal plants in traditional and modern medicine: a review of Thymus vulgaris. International Journal of Clinical Medicine, 6(09), pp.635-642. DOI: https://doi.org/10.4236/ijcm.2015.69084

Kale, O.E. and Awodele, O. (2016). Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats. BMC complementary and alternative medicine, 16(1), pp.1-12. DOI: https://doi.org/10.1186/s12906-016-1188-8

Kale, O.E., Awodele, O. and Akindele, A.J. (2019). Subacute and subchronic oral toxicity assessments of Acridocarpus smeathmannii (DC.) Guill. & Perr. root in Wistar rats. Toxicology Reports, 6, pp.161-175. https://doi.org/10.1016/j.toxrep.2019.01.005 DOI: https://doi.org/10.1016/j.toxrep.2019.01.005

Kpemissi, M., Metowogo, K., Melila, M., Veerapur, V.P., Negru, M., Taulescu, M., Potârniche, A.V., Suhas, D.S., Puneeth, T.A., Vijayakumar, S. and Eklu-Gadegbeku, K. (2020). Acute and subchronic oral toxicity assessments of Combretum micranthum (Combretaceae) in Wistar rats. Toxicology reports, 7, pp.162-168. DOI: 10.1016/j.toxrep.2020.01.007 DOI: https://doi.org/10.1016/j.toxrep.2020.01.007

Mbiri, J.W., Musila, M.N., Ngai, D.N., Njagi, S.M., Mbinda, W.M. and Ngugi, M.P. (2017). Acute and sub-chronic oral toxicity study of methanolic extract of Caesalpinia volkensii (Harms). DOI: https://doi.org/10.4172/2157-7609.1000222

Ndhlala, A.R., Ncube, B., Okem, A., Mulaudzi, R.B. and Van Staden, J. (2013). Toxicology of some important medicinal plants in southern Africa. Food and chemical toxicology, 62, pp.609-621. DOI: https://doi.org/10.1016/j.fct.2013.09.027

Oke, O.L.(1995). Leaf protein research in Nigeria Ibadan. University of Ibadan Press, American Journal of Hypertension Research, 5(1), pp.1-7.

Okokon, J.E., Nwafor, P.A. and Ekpo, M.D. (2010). Subchronic toxicity studies of the ethanolic root extract of Croton zambesicus. Pakistan Journal of Pharmaceutical Sciences, 23(2).

Oreagba, I.A., Oshikoya, K.A. and Amachree, M. (2011). Herbal medicine use among urban residents in Lagos, Nigeria. BMC Complementary and Alternative medicine, 11, pp.1-8. https://doi.org/10.1136%2Fbmjgh-2018-000895 DOI: https://doi.org/10.1186/1472-6882-11-117

Stickel, F. and Shouval, D. (2015). Hepatotoxicity of herbal and dietary supplements: an update. Archives of toxicology, 89, pp.851-865. DOI: https://doi.org/10.1007/s00204-015-1471-3

Teschke, R., Frenzel, C., Schulze, J. and Eickhoff, A. (2012). Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: was causality adequately ascertained?. Regulatory Toxicology and Pharmacology, 63(1), pp.1-9. https://doi.org/10.1016/j.yrtph.2012.02.009 DOI: https://doi.org/10.1016/j.yrtph.2012.02.009

Uadia, P.O., Oriakhi, K., Osemwenkae, P.O. and Emokpae, M.A. (2012). Phytochemical screening and antioxidant capacity of methanolic extract of Tetracarpidium conophorum seeds. Niger J Biochem Mol Biol, 27(1), pp.16-26.

Ugwah-Oguejiofor, C.J., Okoli, C.O., Ugwah, M.O., Umaru, M.L., Ogbulie, C.S., Mshelia, H.E., Umar, M. and Njan, A.A. (2019). Acute and sub-acute toxicity of aqueous extract of aerial parts of Caralluma dalzielii NE Brown in mice and rats. Heliyon, 5(1), p.e01179. https://doi.org/10.1016/j.heliyon.2019.e01179 DOI: https://doi.org/10.1016/j.heliyon.2019.e01179

Unuofin, J.O., Otunola, G.A. and Afolayan, A.J. (2018). Evaluation of acute and subacute toxicity of whole-plant aqueous extract of Vernonia mespilifolia Less. in Wistar rats. Journal of integrative medicine, 16(5), pp.335-341. https://doi.org/10.1016/j.joim.2018.07.003 DOI: https://doi.org/10.1016/j.joim.2018.07.003

Wang, B., Deng, J., Gao, Y., Zhu, L., He, R. and Xu, Y. (2011). The screening toolbox of bioactive substances from natural products: A review. Fitoterapia, 82(8), pp.1141-1151. https://doi.org/10.1016/j.fitote.2011.08.007 DOI: https://doi.org/10.1016/j.fitote.2011.08.007

WHO Expert Committee on the Selection, Use of Essential Medicines and World Health Organization, 2014. The Selection and Use of Essential Medicines: Report of the WHO Expert Committee, 2013 (including the 18th WHO Model List of Essential Medicines and the 4th WHO Model List of Essential Medicines for Children) (Vol. 985). World Health Organization.

Published
2023-06-30
How to Cite
Oriakhi K., & Ikponmwosa-Eweka O. (2023). ACUTE AND SUB CHRONIC TOXICITY PROFILE OF METHANOL EXTRACT OF TETRACARPIDIUM CONOPHORUM SEEDS ON WISTAR ALBINO RATS. FUDMA JOURNAL OF SCIENCES, 7(3), 215 - 223. https://doi.org/10.33003/fjs-2023-0703-1726