AMELIORATIVE POTENTIAL OF ETHANOL LEAF EXTRACT OF ANNONA CHERIMOLA IN ALLOXAN-INDUCED DIABETIC RATS
DOI:
https://doi.org/10.33003/fjs-2023-0702-1711Keywords:
Annona cherimola, blood glucose, diabetes mellitus, metformin, alloxanAbstract
Diabetes mellitus (DM) is a chronic disease characterized by a relative or absolute lack of insulin secretion or insulin inaction. The study investigated the effect of Annona cherimola leaf extract on the liver and kidney function indices of alloxan-induced diabetic rats. A total of twenty (20) albino rats of both sexes weighing about 100g to 200g were used for the study, while eighteen (18) mice were used for the acute toxicity study. The animals were randomly divided into five (5) groups of four (4) rats each; Group 1 was not induced nor treated (normal control), group 2 was induced but not treated (untreated control), group 3 was induced and treated with 100 mg/kg b.w. of metformin (standard control), and groups 4 and 5 were induced and treated with 100 and 200 mg/kg b.w. of the extract respectively. The induction of diabetes was achieved by intraperitoneal injection of alloxan monohydrate (150 mg/kg b.w.). The oral administration (treatment) was done once per day using gavages for fifteen (15) days, and the blood glucose level was checked every three (3) days. The result indicated the extract possessed significant (p < 0.05) antidiabetic effect on groups 4 and 5 compared to the untreated group. A significant (p < 0.05) increase in serum total cholesterol (TC) and triglyceride (TAG) was also observed in groups 4 and 5 compared to the untreated group. In conclusion, this research showed that the ethanol leaf extract of Annona cherimolapossess a potent ameliorative effect in alloxan-induced diabetic rats.
References
Amakom, C.M., Orji, C.E., Eke, B.E., Iroegbu, C., Ojakominor, B.E. (2018). Gross alpha and beta activity concentrations in soil and some selected Nigerian food crops. International Journal of Physical Sciences.
Giri, S., Singh, G., Jha, V., Tripathi, R.M. (2013). Estimation of the annual effective dose due to ingestion of natural radionuclides in foodstuffs and water at a proposed Uranium mining site in India. International Journal of Radiation Biology.
Ibeanu, I.G.E. (1999).Assessment of radiological Effects on the Tin mining Activities in Jos and its Environs. A Ph.D thesis submitted to the department of Physics Ahmadu Bello University Zaria.
Jibiri, N.N (2001). Assessment of health risk levels associated with terrestrial gamma radiation Dose rate in Nigeria. Environment International 27(1):21-26
Jibiri, N.N., Farai, I.P., Alausa, S.K. (2007).Estimation of Annual Effective Dose Due to Natural Radioactive Elements in Ingestion of Foodstuffs in Tin Mining Area of Jos-Plateau, Nigeria. Journal of Environmental Radioactivity, 94, 31-40.
Shanthi, G., Maiyan, C.G., Raj, G.A., Kumaran, J.T. (2009). Radioactivity in food crops from high background radiation area in southwest India. Current Science 10:1331-1335
UNSCEAR (2008): United Nations Scientific committee on the Effects of Atomic Radiation. Sources, effects and risks of ionization radiation, Report to the General Assembly, with Scientific annexes B: Exposures from Natural Radiation Sources New York:
World Health Organization (2001). Infant and young children nutrition. Global strategy for infant and young children feeding
World Health Organization (2004). WHO Guidelines. Quality Control Methods for Medicina Plant Materials. Ge-neva. apps.who.int/medicinedocs/ documents/h1791e /h1791e.pdf
World Health Organization (2008). Guidelines for drinking water quality and other screening levels of various categories of foods. 6th ed.,World Health Organization, Geneva, Switzerland.
Zorer, O.S. and Oter, C. (2015). Evaluation of gross radioactivity in foodstuffs. Article in KerntechnikDOI: 10.3139/124.110492
Published
How to Cite
Issue
Section
FUDMA Journal of Sciences