EVALUATION OF SERUM INTERLEUKINS 1 AND 10 IN TYPE 2 DIABETES MELLITUS SUBJECTS IN BENIN CITY
DOI:
https://doi.org/10.33003/fjs-2023-0702-1203Keywords:
Interleukin-1, Interleukin -10, Diabetes mellitus, Cytokine, InflammationAbstract
Diabetes mellitus is a metabolic and endocrinological disease that results in hyperglycemia as a result of either insulin absence or non-responsiveness of insulin receptors. Interleukins have been implicated in the pathogenesis of diabetes mellitus. This study sought to evaluate serum interleukin-1 and 10 in diabetes mellitus. A total of three hundred subjects comprising of one hundred and eighty diabetes mellitus and one hundred and twenty apparently healthy subjects were recruited. Of the one hundred and eighty diabetes mellitus is made of 41.67% male and 58.33% females. Venous blood samples were collected into fluoride oxalate and plain containers and allowed to clot and the serum harvested. Glucose, IL-1 and IL-10 were estimated using standard methods. Statistical package for social sciences (SPSS) Chicago, USA, version 21 was used for data analysis. Our results show that IL-1 was significantly higher while IL-10 was observed to be significantly lower in diabetes mellitus when compared with apparently healthy subjects. It was observed that interleukin -1 and interleukin -10 were positively associated when correlated. Conclusively, interleukins are important in the pathogenesis of diabetes mellitus and should be evaluated for proper understanding of the pathogenesis of diabetes mellitus.
References
Abel, A.U., Habor, R.G., and Oseribho, I.O . (2020). Adsorption Studies of Oil Spill Clean-up using Coconut Coir Activated Carbon (CCAC). Journal of Applied Chemistry.13: 42-56. http://www.sciencepublishinggroup.com/j/aff
Al-Ghouti, M.A., and Da’ana, D.A. (2020). Guidelines for the use and interpretation of adsorption isotherm models:a review. Journal of Hazardeous Materials.393:122383
American Public Health Association (APHA) (2017). American water works association, Water environment federation. Standard Methods for Examination of Wastewater 23rd edition
Ayawie, N., Ebelegi, A., Wankasi, D. (2017). Modelling and Interpretation of adsorption Isotherm. Journal of Chemistry.
Babel S. and Kurniawan T., (2003). Various treatment technologies to remove arsenic and mercury from contaminated groundwater: an overview. In Proceedings of the First International Symposium on Southeast Asian Water Environment, Bangkok, Thailand,25: 433-440.
Beatrice, W., Isaac, W., Jane, M,. Msagati, T., Ram, M., and Ruth, N. (2016). Remidiation of Lead, Cadmium and Copper Polluted Waters by Onion Skins (Allium Cepa). International Journal of Agriculture Innovations and Research. 4: 2319-1473.
Boukhiar, A., Louhab M., andSahmoune, H., (2008). Kinetic and equilibrium models for the biosorption of Cr (III) on streptomycesrimosus, Research Journal of Applied Science,3:294-30.
Cafer, S., Omer S., and Mehmet, M. (2011). Applications on agricultural and forest waste adsorbents for the removal of lead (II) from contaminated waters. International Journal of Environment Science Technology. 9:379–394.
Cheragi, E., Ameri, E. and Moheb, A. (2015). Adsorption of Cadmium ions from Aqueous Solutions using Sesame as low-cost Biosorbent: Kinetics and equilibrium Studies. International Journal of Environmental Science and Technology. 12(8) :2579-2592.
Evbuomwan, B.O and Opute, C. (2018). The Effectiveness of Low-Cost Adsorbents (Onion and Garlic Skins) In the Removal of Cd (II) from Aqueous Solution. International Journal of Research and Innovation in Applied Science (IJRIAS).3: 2454-6194
Faizan, A and Sadaf Z. (2020). Potential use of Agro/Food Waste as Biosorbents in the Removal of Heavy metals. Intechopen journal. DOI:10.5772/intechopen.9417.
Fakayode, S.O. (2005). Impact Assessment of Industrial Effluent on Water Quality of Receiving Alaro River in Ibadan, Nigeria. African Journal of Environmental Assessment and Management.10: 1-13.
Freitas, P., Iha, M., Felinto, M. and Suárez-Iha, M. (2008). Adsorption of di-2-pyridyl ketone salicyloylhydrazone on Amberlite XAD-2 and XAD-7 resins: Characteristics and isotherms, Journal of Colloid Interface Science, 323: 1–5.
Hariani, P.L., Fatma and Zulkifar. (2015). Alumina-Activated Carbon Composite as Adsorbent for Adsorption of Procion Red Dye from Wastewater Songket Industry. Journal of Pure and Applied. Chemistry Research. 4 (1): 25-33.
Horsefall, M., Abia, A.A. and Spiff, A.J. (2003) Removal of Cu (II) and Zinc ions from waste water by cassava (manihotesculentacranz) waste Biomass. African Journal.of Biotechnology, 2: 360-364.
Hossain, M., Ngo, H.H., Guo, W.S., and Setiadi,T., (2012).Adsorption and Desorption of Copper(II) Ions onto Garden Grass. Journal of Bioresource Technology.121:386-395.
Kwikima, M.M., Mateso S. and Chebude.,(2021).Potentials of agricultural waste as the ultimate alternative adsorbent for cadmium removal from waste water. https://doi.org/10.1016/j.sciaf.2021.e00934
Mojeed, A.A., Abiodun, O.A,. Martins, A.A. and Omobola O.O. (2020). Heavy Metals in Wastewater and Sewage Sludge from Selected Municipal Treatment Plants in Eastern Cape Province, South Africa. MDPI Journal on water.12:2746
Nandiyato, D.B., Oktiani, R., and Ragadhita, R. (2019). How to Read and Interpret FTIR Spectroscope of Organic Material. Indonesian Journal of Science and Technology.4(1):97-118
Nandiyanto, D.B. and Ragadhta, R. (2021). How to Calculate Adsorption isotherms of Particles using Two-Parameter Monolayer Adsorption Models and Equation. Indonesian Journal of Science and Technology. 6:205-234
Selivanovskaya, S. and Latypova, V. (2003). The use of biomasssays for evaluating the toxicity of sewage sludge and sewage sludge-amended soil. Journal of Soil Sediment, 3: 85-92
Singh, S., Ma, L. and Hendry, M. (2006). Characterization of aqueous lead removal by phosphatic clay: equilibrium and kinetic studies. Journal of hazardous Materials, 136: 654– 662.
Soreta, R.T., Yitbarek, M., and Mekonnen, E. (2015). Kinetic and Thermodynamic Studies of the Adsorption of Cr (VI) onto Some Selected Local Adsorbents. South African Journal of Chemistry Research. 68: 45–52.
Surchi, K., (2011). Agricultural wastes as low-cost adsorbents for Pb Removal: Kinetics, equilibrium and thermodynamics. International Journal of Chemistry,3: 103-112.
Zada, A., Afridi, G.S., Shah, M., Khan ,W., Khan, M., Nazir, R., Ullah, M. (2020).The effective removal of heavy metals from water by activated carbon adsorbents of Albizia lebbeck and Melia azedarach seed shells. Journal of Soil and Water Research.1: 30-37
Published
How to Cite
Issue
Section
FUDMA Journal of Sciences