TIME-TO-OPTIMAL CONTROL OF HYPERTENSION USING KAPLAN-MEIER ESTIMATOR, COX PROPORTIONAL HAZARD AND WEIBULL MODEL
Hypertension is a worldwide public health challenge. The study investigated the time it takes to attain an optimal control of hypertension and the major factors that influence the control in Specialist Hospital, Sokoto.
A retrospective cohort study was conducted involving 300 patient records. The population consisted all hypertensive patients on follow-ups at Specialist Hospital Sokoto from1st February, 2015 to 1st February, 2021.Statistical Package for the Social Sciences version 20 and R software were used for descriptive, Kaplan-Meier estimator, Cox Proportional Regression (CPH) Model and Weibull Regression Model analyses.
Hypertensive patients attain an optimal control after a median survival time of 40.43 (at 95% CI: 33.67- 47.19) months (3.37 years) and mean survival time of 44.18 (CI: 37.24-51.12) months (3.68 years). The CPH analysis revealed that the factors that influenced an optimal control of hypertension were body mass index (BMI) (P <0.001), number of anti-hypertensive drugs (P <0.001), place of residence (P = 0.030). similarly, the Weibull model revealed that the factors that affected an optimal control of hypertension were BMI (P <0.01), number of anti-hypertensive drugs (P <0.001), place of residence (P = 0.042) and educational status (P = 0.036).
In conclusion, BMI, number of anti-hypertensive drugs, Place of residence, Educational status. should be watched out during management of hypertensive patients. This also call for an extension of this study through a prospective design to be able to measure the effect of other factors in the achievement of optimal control of hypertension
Akinlua, J. T., Meakin R., Umar, A. M., & Freemantle, N. (2015). Current Prevalence Pattern of Hypertension in Nigeria: A Systematic Review. Plos One, 10(10): e0140021. DOI: https://doi.org/10.1371/jour¬nal.pone.0140021.
Bcheraoui, C. E, Memish, Z. A., Tuffaha, M., Daoud, F., Robinson, M. & Jaber, S. (2014). Hypertension and Its Associated Risk Factors in the Kingdom of Saudi Arabia, 2013: A National Survey. International Journal of Hypertension, Article ID: 564679. https://doi.org/10.1155/2014/564679.
Cappuccio, F. P., Micah, F.B., Emmett, L., Kerry, S. M., Antwi, S., Martin-Peprah, R., & Eastwood, J. B. (2004). Prevalence, Detection, Management and Control of Hypertension in Ashanti, West Africa. Journal of Hypertension, P2. 400, 22, 263-264. https://doi.org/10.1097/00004872-200406002-00927.
Clark, T. G., Bradburn, M. J., Love, S. B., & Altman, D. G. (2003). Survival analysis part I: basic concepts and first analyses. Journal of Cancer. 2003;89:232–238 doi:10.1038/sj.bjc.6601118.
Copyright (c) 2022 FUDMA JOURNAL OF SCIENCES
This work is licensed under a Creative Commons Attribution 4.0 International License.
FUDMA Journal of Sciences