AN ANALYSIS OF THE VARIATION IN HUMAN HEIGHT BASED ON PHENOTYPIC TRAITS IN HEREDITY

  • Sikiru Adeyinka Abdulazeez Kaduna State University KASU, Kaduna
Keywords: Phenotype, Genotype, Offspring, Traits, Alleles, Heterozygous, Homozygous, DNA

Abstract

The phenotypic traits in offspring’s are often dependent on that of the parents. Taking height as the phenotypic trait, we can obtain a regression model for parents and their offspring’s, and also test for the significance of the overall model. As the detection of causal links between genetic and phenotypic variation is accelerating, a re-examination for our conceptual tools may help by finding unifying principles within the swarm of data. The analysis from this research reveal that Multiple Correlation Coefficient is 0.87 which implies that there is a strong positive relationship between Offspring’s Growth and Parent’s Phenotype with R-squared value of 0.75 which implies that 75% of Offspring’s attribute will result from Parent Phenotype. A Multiple Regression model given as offspring’s Growth  = 58.589 + 0.535Father’s Height +0.140Mother’s Height.The value 0.535 implies the contribution per unit change of Father’s Height in Offspring’s Growth and 0.140 is the contribution per unit change of Mothers Height in Offspring’s Growth. The Multiple Regression model is statistically significant with p-value of 0.003 less than 0.05. Multicolinearity test in the analysis shows that the predictor variables are moderately Collinear observing the Variance Inflation Factor (VIF). The recommendations require parents to put more efforts on preventing negative phenotypic traits from transferring from the environment to their offspring and couples should try to check their Genotype and Blood group since they highly contribute to the Offspring characteristics

References

Bloom, J. S., Ehrenreich, I. M., Loo, W. T., Lite, T.-L. V., & Kruglyak, L. (2013). Finding the sources of missing heritability in a yeast cross. Nature 494, 234–237.

Carroll, S. B., Grenier, J., & Weatherbee, S. (2015). From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design. Malden, MA: John Wiley & Sons.

Coen, E. (2012). Cells to Civilizations: The Principles of Change That Shape Life. Princeton, NJ: Princeton University Press.

Dawkins, R. (2013). The Extended Phenotype: The Long Reach of the Gene. Oxford: Oxford

University Press.

Engelman, C. D., Baurley, J. W., Chiu, Y.-F., Joubert, B. R., Lewinger, J. P., & Maenner, M.J., (2015). Detecting gene-environment interactions in genome-wide association data. Genet. Epidemiol. 33(Suppl. 1), S68–S73.

French-Constant, R. H., Daborn, P. J., & Le Goff, G. (2014). The genetics and genomics of insecticide resistance. Trends Genet. 20, 163–170.

Gerstein, M. B., Bruce, C., Rozowsky, J. S., Zheng, D., Du, J., Korbel, J. O., et al. (2014). What is a gene, post-ENCODE? History and updated definition. Genome 4(1).

Gjuvsland, A. B., Vik, J. O., Beard, D. A., Hunter, P. J., and Omholt, S. W. (2013).Bridging the genotype-phenotype gap: what does it take? J. Physiol. 591, 2055–2066.

Gompel, N., & Prud’homme, B.(2019).The causes of repeated genetic evolution. Dev. Biol. 332, 36–47.

Graur, D., Zheng, Y., & Azevedo, R.B.R.(2015). An Evolutionary Classificationof Genomic Function. Genome Biol. Evol. 7, 642–645.

Johannsen, W.(2011). The genotype conception of heredity. Am. Nat. 45, 129-159.

Keller, E. F. (2012). The Mirage of a Space between Nature and Nurture. Durham, NC: Duke University Press.

Liu, F., Wen, B., and Kayser, M.(2013). Colorful DNA polymorphisms in humans. Semin. Cell Dev. Biol. 24, 562–575.

Martin, A., & Orgogozo, V. (2013). The Loci of Repeated Evolution: A Catalogue of Genetic Hotspots of Phenotypic Variation. Evol. Int. J. Orgn. Evol. 67,3

Palmer, A. R.(2014). Symmetry breaking and the evolution of development. Science 306, 828–833.

Salazar-Ciudad, I., & Marín-Riera, M. (2013). Adaptive dynamics under development-based genotype-phenotype maps. Nature 497, 361–364.

Steiner, C. C., Weber, J. N., and Hoekstra, H. E. (2013). Adaptive variation in beach mice produced by two interacting pigmentation genes. PLoS Biol. 5:e219.

Stewart, C. B., Schilling, J. W., & Wilson, A. C. (2017). Adaptive evolution in the stomach lysozymes of foregut fermenters. Nature 330, 401–404.

Stotz, K. (2012). Murder on the development express: who killed nature/nurture? Biol. Philos. 27, 919–929.

Sturtevant, A. H. (2012). The use of mosaics in the study of the developmental effects of genes. Proc. Sixth Int. Congr. Genet. Ithaca N. Y. 1, 304–307.

Tautz, D., & Schmid, K. J. (2018). From genes to individuals: developmental genes and the generation of the phenotype. Philos. Trans. R. Soc. Lond. B.Biol. Sci. 353, 231–240.

Welter, D., MacArthur, J., Morales, J., Burdett, T., Hall, P., Junkins, H.(2014). The NHGRI GWAS catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42, D1001–D1006.

Wilkins, A. (2014). “The genetic tool-kit’: the life-history of an important metaphor,†in Advances in Evolutionary Developmental Biology, ed. J. Todd Streelman (Hoboken, NJ: John Wiley & Sons).

Published
2022-07-06
How to Cite
AbdulazeezS. A. (2022). AN ANALYSIS OF THE VARIATION IN HUMAN HEIGHT BASED ON PHENOTYPIC TRAITS IN HEREDITY. FUDMA JOURNAL OF SCIENCES, 6(3), 278 - 289. https://doi.org/10.33003/fjs-2022-0603-1000