@article{Ekhuemelo_Anyam_Ekhuemelo_2021, title={ANTIFUNGAL ACTIVITY OF CRUDE EXTRACTS OF Euphorbia tirucalli; ISOLATION AND CHARACTERIZATION OF ONE OF ITS BIOACTIVE PRINCIPLES TIRUCALLOL }, volume={4}, url={https://fjs.fudutsinma.edu.ng/index.php/fjs/article/view/474}, DOI={10.33003/fjs-2020-0404-474}, abstractNote={<p>Antifungal properties of extracts from <em>Euphorbia tirucalli</em> against&nbsp;some wood decay fungi were studied<strong>. </strong><em>E. tirucalli </em>fresh sample was harvested, cleansed and chipped into chips of 3 x 2 cm length and breadth. Chipped sample (846.3 g) was macerated in 1000 mL of ethyl acetate, n hexane and methanol solvents, respectively. Column chromatography experiment on <em>E. tirucalli</em> was carried out and antifungal screening was done according to standard method for 7 days to observe zones of inhibition of fungi growth. Broth dilution method was adopted to determine the Minimum Inhibition Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of <em>E. tirucalli </em>extracts and fraction. Results show that <a href="https://en.wikipedia.org/wiki/Fibroporia_vaillantii"><em>Fibroporia vaillantii</em></a><em>, Fomitopsis pinicola, Gloeophyllum sepiarium, Rhizopus sp.</em> and <a href="https://en.wikipedia.org/wiki/Serpula_lacrymans"><em>Serpula lacrymans</em></a> were sensitive to ethyl acetate, n’ hexane and methanol <em>E. tirucalli </em>extracts at concentration of 200 mg/mL with zone of inhibition of&nbsp; 18-26 mm and&nbsp; methanol extract had the highest value of 26 mm. The fraction had zone of inhibition of between 18 and 20 mm which are not significantly different (p&lt;0.05) from 29-35 mm obtained from antibiotics. The MIC of 10 mg/mL and MFC of 20 mg/mL were recorded for extracts against the test fungi while MIC of 50 µg/mL and MFC 200 µg/mL were noted for fraction (Et15), respectively. Fraction (Et15) obtained from <em>E. tirucalli </em>was characterised as tirucallol compound. In conclusion, <em>E. tirucalli </em>extracts and fraction have proved to be effective in the control of wood decay fungi and may serve as control of diseases caused by the test fungi</p&gt;}, number={4}, journal={FUDMA JOURNAL OF SCIENCES}, author={EkhuemeloDavid Oriabure and AnyamJ. V. and EkhuemeloC.}, year={2021}, month={Jun.}, pages={213 - 222} }